Integrated Health Sciences Facility Core

综合健康科学设施核心

• 批准号: 10652261
• 负责人: Nirupama Putcha
• 金额: $ 19.87万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-24 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652261
• 关键词: Address; Advocacy; Advocate; Affect; Animals; Bioinformatics; Biological Specimen Banks; Biometry; Chromium; Communication; Communities; Community Health; Consultations; Core Facility; Data Science; Development Plans; Disease; Ensure; Environmental Exposure; Environmental Hazards; Environmental Health; Environmental Risk Factor; Exposure to; Fostering; Future; Generations; Goals; Health; Health Policy; Health Promotion; Health Sciences; In Vitro; Infrastructure; Institution; Knowledge; Link; Maryland; Mission; Modeling; National Institute of Environmental Health Sciences; Neighborhood Health Center; Outcome; Outcomes Research; Personal Satisfaction; Policies; Population Study; Production; Public Health; Race; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Role; Science; Services; Social Policies; Training; Training and Education; Translating; Translational Research; Translations; Trust; Work; advanced analytics; community based participatory research; community engaged research; community engagement; community organizations; data management; design; experience; faculty community; hazard; human subject; improved; in silico; in vivo; innovation; manufacture; member; multidisciplinary; population health; recruit; sound; translational engagement; translational framework; vulnerable community

ABSTRACT (Integrated Health Sciences Facility Core, IHSFC) The primary mission of the Center for Community Health: Addressing Regional Maryland Environmental Determinants of Disease (CHARMED) is to understand how exposures to environmental factors cause adverse health outcomes and to translate our findings into action to protect and promote the health and well-being of vulnerable communities in the Maryland region. To accomplish this mission, the IHSFC will interact closely with other CHARMED Cores including the Administrative Core (AC), Community Engagement Core (CEC), and the Thematic Research Groups (TRGs), to assist Center members with the design and execution of community- engaged research (CEnR) and co-production of knowledge with community stakeholders. The IHSFC will provide a broad suite of services that will be applied to a CEnR translational framework. To this end, the IHSFC will advance CEnR through fostering and supporting investigator partnerships with community-based organizations, through: Aim 1) assisting them in planning environmental health research; Aim 2) provide them with the necessary resources (expertise, technical) for the execution of scientifically sound, community- responsive research projects; and Aim 3) provide guidance and assistance with effective dissemination and translation of CEnR outcomes and impact to a broad range of stakeholders. These aims will be tightly linked to consultation and other services provided by four interactive teams: 1) Population Health Sciences Team (PHST), 2) Environmental Data Science Team (EDT), 3) Mechanistic Science Team (MST), and 4) Translational Research Team (TST). In close coordination with the CEC and the Executive Committee (EC), the PHST will facilitate stakeholder/investigator team building and creation of inclusive, comprehensive research project plans, that are responsive to the community stakeholder’s needs. The EDT will provide statistical review of study designs and research plans and assist in biostatistical and bioinformatic analyses of results to ensure that all studies are rigorously designed and powered. The MST will provide investigative teams with access to an array of advanced analytical capabilities and infrastructure for the conduct of mechanistic studies needed for basic scientific discovery. The TRT will provide training/education and assistance to Center members and stakeholders in communication and translation of their findings to a broad range of stakeholders in an audience-appropriate manner. The impact of the Center’s research will ideally include but is certainly not limited to an increase in the capacity of CHARMED investigators to conduct translational CEnR research, and to identify the health risks associated with exposures to environmental hazards in the greater Maryland region. Longer term impacts include: 1) changes in community environmental exposures; 2) changes in public health policy; and ultimately in 3) improvements in community health outcomes.

摘要（综合健康科学设施核心，IHSFC） 社区卫生中心的主要使命：解决区域马里兰州环境问题 疾病的决定因素（CHARMED）是为了了解暴露于环境因素如何导致不良反应。 健康结果，并将我们的研究结果转化为行动，以保护和促进健康和福祉， 马里兰州地区的弱势群体。为了完成这一使命，IHSFC将与 其他CHARMED核心，包括行政核心（AC），社区参与核心（CEC）和 专题研究小组（TRG），协助中心成员设计和执行社区- 参与研究（CEnR）和与社区利益相关者共同生产知识。IHSFC将 提供一套广泛的服务，将应用于CEnR翻译框架。为此，IHSFC 将通过促进和支持研究者与社区合作伙伴关系来推进CEnR 目标1）协助他们规划环境卫生研究;目标2）为他们提供 拥有必要的资源（专业知识，技术），以执行科学合理的，社区- 目标3）提供指导和援助，以有效传播和 将CEnR的成果和影响转化为广泛的利益相关者。这些目标将与以下方面紧密相连： 四个互动小组提供咨询和其他服务：1）人口健康科学小组， 2)环境数据科学团队（EDT），3）机械科学团队（MST）和4）翻译 研究团队（TST）。在与CEC和执行委员会（EC）的密切协调下，PHST将 促进利益相关者/研究者团队的建设和创建包容性的，全面的研究项目计划， 对社区利益相关者的需求做出回应。EDT将提供研究的统计审查 设计和研究计划，并协助对结果进行生物统计和生物信息学分析，以确保所有 研究是经过严格设计和驱动的。MST将为调查小组提供访问阵列的权限 先进的分析能力和基础设施的基础设施进行所需的机制研究， 科学发现TRT将为中心成员和利益相关者提供培训/教育和帮助 在沟通和翻译他们的调查结果，以广泛的利益相关者在一个适当的观众， 方式该中心的研究的影响将理想地包括，但当然不限于增加 CHARMED研究人员进行转化CEnR研究和识别健康风险的能力 与大马里兰州地区的环境危害有关。长期影响 包括：1）社区环境暴露的变化; 2）公共卫生政策的变化;以及最终 （3）改善社区健康状况。