RL5: Research Education Core

摘要/摘要 研究教育组成部分(REC)计划 北卡罗来纳大学ADRC的一个主要研究重点是对阿尔茨海默氏症进行前沿研究 疾病(AD)和AD相关痴呆(ADRD)，包括慢性创伤性脑病 (CTE)，特别注意确定不同群体之间的差异和相似之处， 利用BU ADRC的数据丰富环境，具有访问世界级队列的功能 作为Framingham心脏研究、诊断CTE研究、下一代数字和 生物标志物数据集，以及在BU发现的多样化和包容性研究群体 ADRC的希望研究。REC将利用BU ADRC及其附属机构的独特专业知识 学院提供高级研究培训，因为它涉及以下共同主题 AD/ADRD的神经退行性变及相关的研究治疗。REC计划的目标 是：(1)在3个不同的职位中保留4个为期2年的博士后/职业早期实习生 轨道：(A)基础科学轨道；(B)临床科学轨道；(C)数据管理和 生物统计跟踪；(2)确保至少一半的区域经济共同体受训人员是代表性不足的群体和 (3)使受训人员能够过渡到独立。高校学生的科研训练 REC将集中于(1)AD，包括其病理学、病理生理学、危险因素、遗传学、 生物标志物、临床症状和行为表现，以及(2)共同和独特的 与神经退行性变有关的主题，包括如何病理，病理生理学，危险因素， 阿尔茨海默病的遗传学、生物标志物、临床症状和行为表现与 与其他ADRD形成对比。 BU ADRC REC致力于发展不同的独立AD/ADRD队列 来自高级实习生和职业生涯早期教师的研究人员，精通RICH 旨在揭示痴呆症检测和治疗的中枢机制的队列研究。我们会 实现这一目标，并服务于此应用程序中的其他核心，通过提供教学和 基础研究、翻译研究和临床基础方面的实践培训 AD/ADRD，研究基础和关键专业技能培训，重点是 关于负责任地进行动物和人类研究，以及多样化和 以及高质量的、个性化的、详细的指导，以准备 在AD/ADRD研究中获得独立调查员地位的不同受训人员队列。

Summary/Abstract Research Education Component (REC) Program A major research focus of the BU ADRC is to conduct cutting edge research on Alzheimer's disease (AD) and AD related dementias (ADRD), including chronic traumatic encephalopathy (CTE), with special attention to identifying the differences and similarities between groups, leveraging the BU ADRC's data-rich environment featuring access to world-class cohorts such as the Framingham Heart Study, the DIAGNOSE CTE Study, next-generation digital and biomarker datasets, as well as diverse and inclusive research populations found in the BU ADRC's Hope Study. The REC will use the unique expertise of the BU ADRC and affiliated faculty to provide advanced research training as it relates to common themes of neurodegeneration in AD/ADRD and related investigative treatments. The REC program goals are: (1) to maintain 4 postdoctoral/early-career trainees for 2-year terms among 3 different tracks: (a) a basic science track; (b) a clinical science track; and (c) a data management and biostatistics track; (2) to ensure at least half of REC trainees are underrepresented groups and (3) to enable trainees to transition to independence. The scientific and research training of the REC will be focused on (1) AD, including its pathology, pathophysiology, risk factors, genetics, biomarkers, clinical symptoms, and behavioral manifestations, and (2) common and distinct themes related to neurodegeneration, including how pathology, pathophysiology, risk factors, genetics, biomarkers, clinical symptoms, and behavioral manifestations of AD compare and contrast to other ADRD. The BU ADRC REC is committed to developing a diverse cohort of independent AD/ADRD researchers from advanced trainees and early-career faculty, savvy in working across rich cohort studies to unlock central mechanisms in the detection and treatment of dementia. We will achieve this objective, and serve the other Cores in this application, by providing didactic and practical training in essential basic and translational research and clinical fundamentals of AD/ADRD, training in research fundamentals and critical professional skills, with an emphasis on the responsible conduct of research with animal and human subjects, and diverse and vulnerable populations, and high quality, individualized, detailed mentorship to prepare a diverse cohort of trainees for independent investigator status in AD/ADRD research.