RL5: Research Education Core

总结/摘要 研究教育部分（REC）计划 BU ADRC的一个主要研究重点是对阿尔茨海默氏症进行前沿研究 疾病（AD）和AD相关痴呆（ADRD），包括慢性创伤性脑病 (CTE)，并特别注意确定群体之间的差异和相似之处， 利用BU ADRC的数据丰富的环境，可以访问世界一流的队列， 作为心脏病研究，诊断CTE研究，下一代数字和 生物标志物数据集，以及BU中发现的多样化和包容性研究人群 ADRC的希望研究REC将利用BU ADRC及其附属机构的独特专业知识， 教师提供先进的研究培训，因为它涉及到共同的主题， AD/ADRD中的神经变性和相关研究治疗。REC计划目标 （1）保留4名博士后/早期职业培训生，为期2年， 轨道：（a）基础科学轨道;（B）临床科学轨道;和（c）数据管理和 生物统计学轨道;（2）确保至少一半的REC受训人员是代表性不足的群体， (3)使学员能够过渡到独立。科研训练 REC将重点关注（1）AD，包括其病理学，病理生理学，危险因素，遗传学， 生物标志物、临床症状和行为表现，以及（2）共同和不同 与神经变性相关的主题，包括病理学，病理生理学，风险因素， AD的遗传学、生物标志物、临床症状和行为表现进行比较， 与其他ADRD不同。 BU ADRC REC致力于开发一个多样化的独立AD/ADRD队列 来自高级学员和早期职业教师的研究人员，精通在丰富的 队列研究，以揭示痴呆症检测和治疗的中心机制。我们将 实现这一目标，并服务于其他核心在这个应用程序中，通过提供教学和 在基本的基础和转化研究和临床基础的实践培训， AD/ADRD，研究基础和关键专业技能培训，重点是 关于负责任地进行动物和人类受试者的研究， 弱势群体，以及高质量，个性化，详细的指导， 在AD/ADRD研究中获得独立研究者地位的不同学员队列。

Summary/Abstract Research Education Component (REC) Program A major research focus of the BU ADRC is to conduct cutting edge research on Alzheimer's disease (AD) and AD related dementias (ADRD), including chronic traumatic encephalopathy (CTE), with special attention to identifying the differences and similarities between groups, leveraging the BU ADRC's data-rich environment featuring access to world-class cohorts such as the Framingham Heart Study, the DIAGNOSE CTE Study, next-generation digital and biomarker datasets, as well as diverse and inclusive research populations found in the BU ADRC's Hope Study. The REC will use the unique expertise of the BU ADRC and affiliated faculty to provide advanced research training as it relates to common themes of neurodegeneration in AD/ADRD and related investigative treatments. The REC program goals are: (1) to maintain 4 postdoctoral/early-career trainees for 2-year terms among 3 different tracks: (a) a basic science track; (b) a clinical science track; and (c) a data management and biostatistics track; (2) to ensure at least half of REC trainees are underrepresented groups and (3) to enable trainees to transition to independence. The scientific and research training of the REC will be focused on (1) AD, including its pathology, pathophysiology, risk factors, genetics, biomarkers, clinical symptoms, and behavioral manifestations, and (2) common and distinct themes related to neurodegeneration, including how pathology, pathophysiology, risk factors, genetics, biomarkers, clinical symptoms, and behavioral manifestations of AD compare and contrast to other ADRD. The BU ADRC REC is committed to developing a diverse cohort of independent AD/ADRD researchers from advanced trainees and early-career faculty, savvy in working across rich cohort studies to unlock central mechanisms in the detection and treatment of dementia. We will achieve this objective, and serve the other Cores in this application, by providing didactic and practical training in essential basic and translational research and clinical fundamentals of AD/ADRD, training in research fundamentals and critical professional skills, with an emphasis on the responsible conduct of research with animal and human subjects, and diverse and vulnerable populations, and high quality, individualized, detailed mentorship to prepare a diverse cohort of trainees for independent investigator status in AD/ADRD research.