Shape Analysis Toolbox: From medical images to quantitative insights of anatomy

项目总结 三维形状是理解我们周围的物理物体的核心。形状 分析工具箱(SALT)被创建为高级形状建模和 分析方法论作为一个开源的、全面的、免费分发的软件。在过去四年中 多年来，我们已经成功地提高了最先进的形状的易用性和有效性 为需要此类技术的生物医学研究人员提供分析方法。 我们现在建议对我们的方法和我们的传播模式进行必要和新颖的改进，以便 继续最大限度地提高SALT的成功。我们还将修改SALT的架构以更好地集成 通过提高效率和脚本编写功能实现生物医学成像研究工作流SlicerSALT 可批量部署，用于大规模顺序计算。我们还将把重点从 将形状建模融入最新的统计形状分析方法，为临床服务 并提高形状生物标志物的可解释性。我们将继续传播小说 最佳演示如何使用我们的工具执行有影响力的研究的示例应用程序，并将提供 用于用户支持的全数字文档。 SlicerSALT的最终目标是最大化中包含的几何信息的潜在好处 医疗数据，并扩大其用途，超越简单的可视化，以支持临床研究。

PROJECT SUMMARY Three-dimensional shape lies at the core of understanding the physical objects that surround us. The Shape AnaLysis Toolbox (SALT) was created to be a dissemination vehicle for advanced shape modeling and analysis methodology as an open-source, comprehensive and freely distributed software. Over the past four years, we have been successful in increasing the ease of use and effectiveness of state-of-the-art shape analysis methodology for biomedical researchers in need of such techniques. We now propose necessary and novel enhancements to our methods and our dissemination model in order to continue maximizing the success of SALT. We will also modify the architecture of SALT to better integrate biomedical imaging research workflows by improving the efficiency and scripting capabilities so SlicerSALT can be deployed in batch mode for large-scale sequential computations. We will also shift our focus from shape modeling into state-of-the-art statistical shape analysis methodologies, necessary to serve clinical applications and to increase the interpretability of shape biomarkers. We will continue to disseminate novel example applications that best demonstrate how to use our tools to perform impactful research and will provide fully digital documentation for user support. The ultimate goal of SlicerSALT is to maximize the potential benefits of the geometric information contained in medical data and to expand its use beyond simple visualization to support clinical research.