Shape Analysis Toolbox: From medical images to quantitative insights of anatomy

项目摘要 三维形状是理解我们周围物体的核心。形状 AnalLysis ®（SALT）的创建是为了传播先进的形状建模工具， 分析方法作为一个开源的，全面的和免费分发的软件。过去四 多年来，我们已经成功地提高了易用性和最先进的形状的有效性 分析方法的生物医学研究人员需要这样的技术。 我们现在提出必要的和新的增强我们的方法和我们的传播模型，以 继续最大限度地发挥限制战略武器会谈的作用。我们还将修改SALT的架构，以更好地集成 生物医学成像研究工作流程，提高效率和脚本功能，使SlicerSALT 可以以批处理模式部署，用于大规模的顺序计算。我们还将把重点从 形状建模到最先进的统计形状分析方法，为临床服务所必需 应用和增加形状生物标志物的可解释性。我们将继续传播小说 示例应用程序，最好地展示了如何使用我们的工具来执行有影响力的研究，并将提供 完全数字化的文档，以提供用户支持。 SlicerSALT的最终目标是最大限度地发挥 医疗数据，并将其使用扩展到简单的可视化之外，以支持临床研究。

PROJECT SUMMARY Three-dimensional shape lies at the core of understanding the physical objects that surround us. The Shape AnaLysis Toolbox (SALT) was created to be a dissemination vehicle for advanced shape modeling and analysis methodology as an open-source, comprehensive and freely distributed software. Over the past four years, we have been successful in increasing the ease of use and effectiveness of state-of-the-art shape analysis methodology for biomedical researchers in need of such techniques. We now propose necessary and novel enhancements to our methods and our dissemination model in order to continue maximizing the success of SALT. We will also modify the architecture of SALT to better integrate biomedical imaging research workflows by improving the efficiency and scripting capabilities so SlicerSALT can be deployed in batch mode for large-scale sequential computations. We will also shift our focus from shape modeling into state-of-the-art statistical shape analysis methodologies, necessary to serve clinical applications and to increase the interpretability of shape biomarkers. We will continue to disseminate novel example applications that best demonstrate how to use our tools to perform impactful research and will provide fully digital documentation for user support. The ultimate goal of SlicerSALT is to maximize the potential benefits of the geometric information contained in medical data and to expand its use beyond simple visualization to support clinical research.