Research Training in Mood and Anxiety Disorders: From Animal Models to Patients

项目摘要 本申请是为了更新资助T32 MH 15144，“情绪和焦虑障碍的研究培训： 从动物模型到患者”，自1978年以来一直得到资助。目标是培养博士后（MD， MD/PhD和PhD）研究员作为独立研究人员的职业。我们目标的实现是通过 有多少研究员在K奖或其他来源的支持下继续从事研究密集型的研究 资金。在为期三年的密集计划研究员学习确定关键的研究问题，制定 假设，并设计和执行测试这些假设的实验。研究员所需的其他技能 要成为一名独立的研究人员，包括了解成功研究的管理 企业，有效的合作和写作赠款。关于负责任行为的全面培训 研究在奖学金的早期就开始了。一个研究员必须保持最高标准的科学诚信， 了解与人类和动物研究相关的伦理问题， 培训计划的成功体现在受训人员的成就和多样性上。 的研究员。在过去的15年里，48名研究员得到了T32的支持; 44%是女性，42%是医学博士，25%是 MD/PhD和33%的PhD。41%的研究员毕业于哥伦比亚精神病学住院医师项目，59%的研究员毕业于哥伦比亚大学精神病学住院医师项目。 研究员来自哥伦比亚以外的地方。13%的研究员是代表性不足的少数民族，27%来自 文化或种族背景，要么不是高加索人，要么不是来自北美或欧洲。毕业 率为97%，包括2名目前的第三年研究员谁毕业6/30/18）（一名研究员谁没有毕业 1年后离开，在约翰霍普金斯医学院获得终身研究职位，并获得了K- 23奖）。目前有6名研究员：2名三年级、1名二年级和3名一年级; 2名研究员已 接受开始在2018年7月，使48名研究员支持的T32在过去的15年。的42 在过去15年中毕业的研究员中，69%获得了K奖。在21名研究员中， 已经完成K奖，71%已经获得R系列奖。在过去的15年里， 4年毕业，所有4人都获得了K奖（所有人都是MD/PhD-目前有2名URM正在培训）。两 其中的URM还收到了单独的R 01。52%的研究员获得了大量的基金会赠款（20 NARSAD，2美国自杀预防基金会，1罗伯特伍德约翰逊）。七个家伙谁没有 获得K获得基金会补助金（6个NARSAD，1个AFSP），因此总共有86%的毕业生获得了 独立融资。在过去15年的42名毕业生中，76%在研究密集型岗位， 12%从事研究相关工作。

Project Summary This application is for renewal of grant T32MH15144, “Research Training in Mood and Anxiety Disorders: From Animal Models to Patients”, that has been funded since 1978. The goal is to train postdoctoral (MD, MD/PhD, and PhD) fellows for careers as independent researchers. Achievement of our goal is measured by how many fellows continue in a research-intensive trajectory whether supported by a K award or other sources of funding. During an intensive three-year program fellows learn to identify key research questions, formulate hypotheses, and design and execute experiments that test those hypotheses. Other skills required for a fellow to become an independent researcher include understanding the administration of a successful research enterprise, effective collaboration and writing grants. Comprehensive training in the Responsible Conduct of Research begins early in the fellowship. A fellow must maintain the highest standards of scientific integrity and understand the ethical issues relevant to human and animal research, The success of the training program is reflected by the accomplishments of the trainees and in the diversity of the fellows. In the past 15 years, 48 fellows have received support from the T32; 44% female, 42% MDs, 25% MD/PhDs and 33% PhDs. 41% of fellows graduated from the Columbia Psychiatric Residency program, 59% of fellows came from outside Columbia. 13% of the fellows are under-represented minorities and 27% come from cultural or ethnic backgrounds that are either not Caucasian or not from North America or Europe. The graduation rate is 97% including the 2 current third year fellows who graduate 6/30/18) (the one fellow who did not graduate left after 1 year for a tenure-track research position at the Johns Hopkins School of Medicine and received a K- 23 award). Currently, there are 6 fellows: 2 third-year, 1 second-year, and 3 first-year; two fellows have been accepted to begin in July 2018, making a total of 48 fellows supported by the T32 in the last 15 years. Of the 42 fellows who graduated the program in the last 15 years, 69% have received K awards. Of the 21 fellows who have finished their K awards, 71% have already received an R series award. All 4 minority fellows in the last 15 years graduated and all 4 received K awards (all were MD/PhDs – there are 2 URMs currently in training). Two of these URMs have also received individual R01s. 52% of fellows received significant foundation grants (20 NARSADs, 2 American Foundation for Suicide Prevention, 1 Robert Wood Johnson). Seven fellows who did not receive a K received a foundation grant (6 NARSADs, 1 AFSP) so in total 86% of graduates have received independent funding. Of the 42 graduates in the past 15 years, 76% are in research-intensive positions and 12% are in research-related positions.