Comparative Toxicogenomics Database (CTD)

摘要 大多数人类疾病涉及遗传和环境因素之间的相互作用。尽管 环境与大多数慢性疾病有关，其病因和作用机制 这些疾病仍然不清楚。据估计，目前有超过8万种化学品用于 商业，对化学作用机制和优先顺序的阐述具有挑战性 环境健康研究。需要集成各种数据才能了解环境- 疾病关联、化学作用机制、毒性预测和有效药物的开发 治疗性干预。2004年，比较毒理基因组学数据库(CTD； Http://ctdbase.org)是公开发布的，目的是解决对公共数据资源的未满足需求 专门致力于促进对环境与疾病联系的理解。今天, 通过多样化的筹资方式和回应不断变化的环境需求 健康研究社区，CTD提供了一组注释丰富的数据，描述了化学物质- 基因-表型-疾病网络、暴露信息和新的分析工具，使用户- 推动了关于环境对人类健康影响的发现。目前，CTD提供&gt；2.5 对16,400种化学物质、51,300种基因/蛋白质、5,500种表型、 和7200种疾病，与来自大约600个物种的870多个解剖学术语联系在一起。 CTD精选数据已集成到&gt；145其他生物医学资源中，进一步扩展了 其影响的范围。CTD已成为环境健康研究的宝贵资源 社区依赖。我们正在申请资金以：1)继续推进对 通过正在进行的手册，环境暴露与人类健康之间的复杂联系 管理科学文献中的化学物质、基因、表型、疾病和暴露数据； 评价和整合选定的外部数据集；以及基线技术支持；2)加强 通过进一步开发我们的文本挖掘和在线管理工具来提高管理效率；以及3) 有选择地重组现有代码、软件和数据库设计(重构)，以改进 CTD的结构和性能。这一拟议的项目将保护和扩大美国国立卫生研究院在 CTD，并确保为环境健康研究持续提供这一关键资源 社区。

ABSTRACT Most human diseases involve interactions between genetic and environmental factors. Although the environment is implicated in most chronic diseases, the etiology and mechanisms of action underlying these diseases remain unclear. It is estimated that more than 80,000 chemicals are currently used in commerce, challenging elucidation about chemical mechanisms-of-action and prioritization of environmental health research. Integration of diverse data is required to understand environment- disease associations, mechanisms of chemical action, toxicity prediction and development of effective therapeutic interventions. In 2004, the Comparative Toxicogenomics Database (CTD; http://ctdbase.org) was launched publicly to address an unmet need for a public data resource dedicated exclusively to advancing understanding about environment-disease connections. Today, through diversified funding approaches and in response to the evolving needs of the environmental health research community, CTD provides a combination of richly annotated data describing chemical- gene-phenotype-disease networks, exposure information, and novel analysis tools that enable user- driven discoveries about environmental influences on human health. Currently, CTD provides >2.5 million manually curated relationships for 16,400 chemicals, 51,300 genes/proteins, 5,500 phenotypes, and 7,200 diseases, contextualized with over 870 anatomical terms from approximately 600 species. CTD curated data has been integrated into >145 other biomedical resources further extending the reach of its impact. CTD has become a valued resource on which the environmental health research community relies. We are requesting funding to: 1) continue advancing understanding about the complex connections between environmental exposures and human health through ongoing manual curation of chemicals, genes, phenotypes, diseases and exposure data from the scientific literature; evaluation and integration of select external data sets; and baseline technical support; 2) enhance curation efficiency through further development of our text-mining and online curation tools; and 3) selectively restructure existing code, software, and database design (refactoring) to improve the structure and performance of CTD. This proposed project will protect and extend NIH investments in CTD and ensure the ongoing provision of this key resource for the environmental health research community.