Comparative Toxicogenomics Database (CTD)

比较毒理基因组学数据库 (CTD)

• 批准号: 10472552
• 负责人: Allan Peter Davis
• 金额: $ 144.38万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472552
• 关键词: Address; Anatomy; Area; Asthma; Biological; Biological Process; Biology; Chemical Actions; Chemical Exposure; Chemicals; Chronic; Chronic Disease; Code; Commerce; Communities; Complex; Computer software; Data; Data Analyses; Data Set; Databases; Development; Diabetes Mellitus; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Etiology; Evaluation; Exposure to; Funding; Gene Proteins; Genes; Genetic; Goals; Growth; Health; Human; Hypertension; Infrastructure; Investments; Knowledge; Literature; Malignant Neoplasms; Manuals; Obesity; Outcome; Pathway interactions; Peer Review; Performance; Phenotype; Productivity; Research; Resources; Review Literature; Software Design; Structure; System; Therapeutic Intervention; Time; Toxic effect; Toxicogenomics; United States National Institutes of Health; Widespread Disease; base; biomedical resource; comparative; data complexity; data integration; data resource; database design; design; disease phenotype; diverse data; experience; exposed human population; human disease; improved; innovation; insight; knowledgebase; novel; preservation; research and development; response; text searching; therapeutically effective; tool; web-based tool

ABSTRACT Most human diseases involve interactions between genetic and environmental factors. Although the environment is implicated in most chronic diseases, the etiology and mechanisms of action underlying these diseases remain unclear. It is estimated that more than 80,000 chemicals are currently used in commerce, challenging elucidation about chemical mechanisms-of-action and prioritization of environmental health research. Integration of diverse data is required to understand environment- disease associations, mechanisms of chemical action, toxicity prediction and development of effective therapeutic interventions. In 2004, the Comparative Toxicogenomics Database (CTD; http://ctdbase.org) was launched publicly to address an unmet need for a public data resource dedicated exclusively to advancing understanding about environment-disease connections. Today, through diversified funding approaches and in response to the evolving needs of the environmental health research community, CTD provides a combination of richly annotated data describing chemical- gene-phenotype-disease networks, exposure information, and novel analysis tools that enable user- driven discoveries about environmental influences on human health. Currently, CTD provides >2.5 million manually curated relationships for 16,400 chemicals, 51,300 genes/proteins, 5,500 phenotypes, and 7,200 diseases, contextualized with over 870 anatomical terms from approximately 600 species. CTD curated data has been integrated into >145 other biomedical resources further extending the reach of its impact. CTD has become a valued resource on which the environmental health research community relies. We are requesting funding to: 1) continue advancing understanding about the complex connections between environmental exposures and human health through ongoing manual curation of chemicals, genes, phenotypes, diseases and exposure data from the scientific literature; evaluation and integration of select external data sets; and baseline technical support; 2) enhance curation efficiency through further development of our text-mining and online curation tools; and 3) selectively restructure existing code, software, and database design (refactoring) to improve the structure and performance of CTD. This proposed project will protect and extend NIH investments in CTD and ensure the ongoing provision of this key resource for the environmental health research community.

抽象的 大多数人类疾病涉及遗传因素和环境因素之间的相互作用。虽然 环境与大多数慢性疾病，病因和作用机制有关 这些疾病尚不清楚。据估计，目前使用了80,000多种化学品 商业，对化学机制的挑战性阐明和优先考虑 环境健康研究。需要集成不同的数据才能了解环境 - 疾病关联，化学作用机制，毒性预测和有效的发展 治疗干预措施。 2004年，比较毒物学数据库（CTD； http://ctdbase.org）公开启动以满足对公共数据资源的未满足需求 专门用于促进对环境疾病连接的理解。今天， 通过多元化的资金方法和回应环境的不断发展的需求 卫生研究界，CTD提供了描述化学物质的丰富注释数据的组合 基因 - 表型 - 疾病网络，暴露信息和新颖的分析工具，可实现用户 关于环境影响人类健康的驱动发现。目前，CTD提供> 2.5 16,400种化学物质，51,300个基因/蛋白质，5,500个表型的百万手动策划关系， 有7,200种疾病，具有来自大约600种的870多种解剖学术语的背景。 CTD策划的数据已集成到> 145个其他生物医学资源中，进一步扩展了 影响其影响。 CTD已成为环境健康研究的重要资源 社区依靠。我们要求提供资金：1）继续促进对 环境暴露与人类健康之间的复杂联系通过持续的手册 来自科学文献的化学物质，基因，表型，疾病和暴露数据的策划； 精选外部数据集的评估和集成；和基线技术支持； 2）增强 通过进一步开发我们的文本挖掘和在线策展工具，策展效率； 3） 有选择地重组现有的代码，软件和数据库设计（重构）以改进 CTD的结构和性能。这个拟议的项目将保护和扩展NIH投资 CTD并确保为环境健康研究提供此关键资源 社区。