A randomized controlled pilot study to examine the impact of a filmed dramatized story intervention (telenovela/soap opera) for HIV prevention in Latinas

一项随机对照试点研究，旨在检验电影化故事干预（电视剧/肥皂剧）对拉丁裔艾滋病毒预防的影响

• 批准号: 10403030
• 负责人: Natalia Andrea Villegas Rodriguez
• 金额: $ 33.99万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10403030
• 关键词: AIDS prevention; Access to Information; Acquired Immunodeficiency Syndrome; Acute; Address; Affect; Age; Attention; Awareness; Behavior; Belief; Biological; COVID-19; Cellular Phone; Central America; Clinical Trials; Communities; Comprehension; Data Collection; Devices; Effectiveness of Interventions; Emotional; Emotions; Ensure; Environment; Female of child bearing age; Film; Funding; Future; Goals; Grant; HIV; HIV Infections; HIV diagnosis; Health; Healthcare Systems; Hispanic; Human immunodeficiency virus test; Individual; Infection; Infrastructure; Institutional Review Boards; Intervention; Knowledge; Latina Population; Location; Love; Mediating; Mental Depression; Mexico; National Institute of Drug Abuse; National Institute on Minority Health and Health Disparities; Neighborhoods; Outcome; Participant; Perception; Pilot Projects; Preparation; Prevention; Preventive; Procedures; Protocols documentation; Randomized; Randomized Clinical Trials; Reporting; Research; Risk; Self Efficacy; Soaps; Stigmatization; Substance abuse problem; Technology; Testing; Time; Training; United States; Woman; Women' s Group; Work; acceptability and feasibility; age group; base; behavior change; behavior influence; built environment; condoms; cost; data management; disparity reduction; efficacy study; efficacy trial; feasibility testing; follow-up; human old age (65+); innovation; intervention delivery; intimate partner violence; multidisciplinary; novel; online delivery; online intervention; pilot test; pre-exposure prophylaxis; prevent; programs; public health relevance; recruit; reduced substance abuse; response; retention rate; role model; social cognitive theory; social culture; theories; usability; web site

PROJECT SUMMARY/ABSTRACT Latinas continue to be affected disproportionally by HIV in the United States (US). Often, Latinas are not aware of their HIV status. Also, their perception of low risk for HIV interferes with condom use, HIV testing and lack of awareness, access, and use of Pre-exposure Prophylaxis [PrEP]. About 60% of total HIV cases in NC occur among women of childbearing age, thus vulnerability to HIV is particularly acute among Latinas between ages 18 and 44 years old, an age group with the highest rate of new HIV infections in NC. These disparities indicate that HIV prevention among Latinas is urgent; therefore, we propose an innovative intervention – a filmed dramatized story (telenovela/soap opera) Infección de Amor (Love Infection) – culturally tailored for Latinas in the US and delivered online. Infección de Amor was filmed and developed but has not been tested with our target audience. The proposed study will pilot test IA and move the intervention to online using a website that will allow individual access around the clock from any location and device, such as a smartphone, ensuring wide dissemination of the intervention in the future. We propose a two-year planning grant (R34) to prepare for an R01 efficacy trial. Our aims are to: 1) Develop the intervention delivery website, conduct a website usability test, and test the feasibility and acceptability of the IA intervention (four telenovela episodes) with 10 Latinas, 2) Conduct a randomized controlled pilot study to examine change in HIV prevention behaviors (condom use; HIV testing; and PrEP awareness, access, and use) comparing 71 intervention and 71 control Latinas from baseline (Time 1 [T1], 0 months) to post-active intervention (Time 2 [T2], 1 month), and to six months follow-up, a period with no contact from the study staff (Time 3 [T3, 7 months]), and 3) Complete establishing the study infrastructure, expanding our multidisciplinary team, building our research partnerships with the community, finalize the protocol and training materials, refine recruitment and retention strategies, data collection and data management procedures, and obtain institutional review board approval in preparation for an R01 efficacy study. We address the National Institute on Drug Abuse (NIDA) goal #4: increase NIDA research and programs’ public impact. We aim to use a novel intervention to advance HIV prevention for Latinas. We will implement a culturally durable and feasible intervention for Latinas.

项目总结/文摘