Malawi Cancer Outcomes Research Program (M-CORP)

马拉维癌症结果研究计划 (M-CORP)

• 批准号: 10402880
• 负责人: Lameck Chinula
• 金额: $ 26.89万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10402880
• 关键词: AIDS Malignancy Consortium; AIDS related cancer; Acquired Immunodeficiency Syndrome; Address; Africa South of the Sahara; African; Cancer Burden; Cancer Control; Cervical Cancer Screening; Cessation of life; Clinical Trials; Collaborations; Country; Databases; Educational Curriculum; Ensure; Environment; Epidemiology; Foundations; Funding; Generations; Grant; HIV/TB; Human Development; Institution; International; Leadership; Lymphoma; Malaria; Malawi; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of esophagus; Medicine; Mentors; National Cancer Institute; North Carolina; Outcome; Outcomes Research; Postdoctoral Fellow; Program Evaluation; Research; Research Personnel; Research Priority; Research Project Grants; Testing; Time; Training Programs; Translational Research; USAID; Universities; anticancer research; base; cancer clinical trial; career; college; experience; indexing; investigator training; malignant breast neoplasm; multidisciplinary; programs; skills; success; training opportunity

PROJECT SUMMARY Globally, there are more deaths from cancer than from HIV, tuberculosis, and malaria combined. In 2018, there were more than 18 million new cancer cases and 9.5 million cancer deaths worldwide, and, by 2030, these numbers will increase by at least 50%. Countries with low or medium Human Development Index account for more than 60% of cancer cases and 70% of cancer deaths. Cancer deaths in sub-Saharan Africa occur disproportionately from cancers that are preventable and/or curable including lymphoma, cervical cancer and breast cancer. Addressing the substantial burden of cancer requires a new generation of cancer researchers who can test hypotheses in the African context. The University of North Carolina Project- Malawi (UNCPM) has a rich cancer research environment that includes participation in the National Cancer Institute (NCI) U54 consortium for HIV associated malignancies, the AIDS Malignancy Consortium, the International Epidemiologic Databases to Evaluate AIDS (IeDEA), NCI African Esophageal Cancer Consortium, and a USAID-funded cervical cancer screening study. To date, UNCPM has had significant success in cancer clinical trials and translational research projects, and in establishing a handful of early- career investigators, but momentum is needed to build on this foundation. First, large improvements in cancer control in Malawi require approaches that extend beyond clinical trials to cancer outcomes research, a broader approach that requires unique skills. At this time, there are few cancer researchers with both the necessary cancer research skills and the local experience to develop cancer outcomes solutions adapted to the Malawian context. Second, there is no defined pipeline for early-career cancer research capacity. Finally, there are few opportunities for successful Malawian investigators to obtain the additional skills and experience necessary to be competitive for independent research funding. To address these gaps, we propose to establish the Malawi Cancer Outcomes Research Program (M-CORP). This application is led by UNC in conjunction with the University of Malawi College of Medicine (COM) and in collaboration with other national and international institutions and training programs. M-CORP aims to increase the cadre of trained investigators who can pursue independent research careers by: 1) establishing a robust curriculum and training opportunities across the continuum of cancer outcomes research specific to the Malawian environment and research priorities; 2) supporting advanced degrees; and 3) overcoming obstacles to research independence by providing post- doctoral opportunities including mentored pilot grants. We will use a multi-PD leadership strategy based at both UNC and UNCPM that will optimize our strengths across the spectrum of cancer outcomes research. An exceptional pool of multidisciplinary mentors, a detailed plan for program evaluation, and robust, broad-based partnerships between UNC and Malawian institutions ensure that M-CORP objectives will be met and will establish Malawi as an internationally recognized center of excellence for cancer outcomes research.

项目摘要 在全球范围内，死于癌症的人数比死于艾滋病毒、结核病和疟疾的人数总和还要多。2018年 全世界有超过1800万新发癌症病例和950万癌症死亡，到2030年， 数量将增加至少50%。人类发展指数低或中等的国家占 超过60%的癌症病例和70%的癌症死亡。撒哈拉以南非洲的癌症死亡人数 可预防和/或可治愈的癌症，包括淋巴瘤、宫颈癌和 乳腺癌解决癌症的巨大负担需要新一代的癌症 可以在非洲背景下检验假设的研究人员。北卡罗来纳州大学项目- 马拉维（UNCPM）拥有丰富的癌症研究环境，包括参与国家癌症研究中心（NCI）。 研究所（NCI）U 54艾滋病毒相关恶性肿瘤联盟，艾滋病联盟， 评估艾滋病的国际流行病学数据库（IeDEA），NCI非洲食管癌 财团和美国国际开发署资助的宫颈癌筛查研究。到目前为止，联合国预防犯罪和刑事司法委员会已取得重大进展， 在癌症临床试验和转化研究项目中取得成功，并建立了一些早期 职业调查员，但需要在此基础上再接再厉。第一，癌症的大幅度改善 马拉维的控制需要从临床试验扩展到癌症结果研究的方法， 这种方法需要独特的技能。目前，很少有癌症研究人员同时具备必要的 癌症研究技能和当地经验，以制定适合马拉维的癌症结局解决方案， 上下文其次，没有明确的早期职业癌症研究能力的管道。最后， 成功的马拉维调查人员有机会获得必要的额外技能和经验， 在独立研究资金方面具有竞争力。为了弥补这些差距，我们建议建立马拉维 癌症结果研究计划（M-CORP）。这项申请由教育署牵头， 马拉维大学医学院（COM），并与其他国家和国际 机构和培训计划。M-CORP旨在增加训练有素的调查人员队伍， 独立的研究事业：1）建立一个强大的课程和培训机会， 针对马拉维环境和研究优先事项的癌症结果研究的连续性; 2） 支持高级学位; 3）通过提供博士后研究生， 博士生的机会，包括指导试点赠款。我们将使用基于以下两点的多PD领导策略： 联合国癌症研究所和联合国癌症预防机制将优化我们在癌症结果研究领域的优势。一个 多学科导师的特殊池，详细的计划评估计划，以及强大的，基础广泛的 马拉维和马拉维机构之间的伙伴关系确保了M-CORP目标的实现， 建立马拉维作为一个国际公认的卓越中心的癌症成果研究。