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Coupling of Protein Synthesis with Cell Division

Coupling of Protein Synthesis with Cell Division
蛋白质合成与细胞分裂的耦合
批准号:
10402935
负责人:
MICHAEL S POLYMENIS
金额:
$37.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
未结题
起止时间:
2017-05-26 至 2025-03-31

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中文摘要
翻译
蛋白质合成决定细胞是否分裂、分裂的速度和分裂的次数。然而蛋白质合成是怎样的
英文摘要
Protein synthesis governs if, how fast, and how many times cells divide. Yet how protein synthesis is linked molecularly with cell division is unknown. We will use budding yeast as a model system to answer this problem because yeast has unique properties suited for genetic and biochemical studies. In the previous period, we identified transcripts that engage with the protein synthesis machinery, the ribosomes, in the process of translation in synchronously dividing cells that maintained the physiological coupling of protein synthesis with their division. We will leverage these findings to tackle the long- standing problem of protein synthesis requirements for cell division. In Aim 1, we will identify how translational control of lipogenesis impinges on nuclear morphology. We propose experiments to test the idea that translational control of lipid synthesis, together with lipid-transfer proteins, impact specific parts of lipid metabolism, to control the morphology of the nucleus in the cell cycle. We will also measure the changing levels of lipids in the nucleus during cell division. In Aim 2, we will determine how outputs of one-carbon metabolic pathways change in the cell cycle and respond to translational control. Our data point to the critical roles of enzymes that are part of the folate-based, one-carbon metabolism. We will identify how protein synthesis controls the expression of enzymes of one-carbon metabolism. We will also measure how the different metabolite inputs and outputs of one-carbon metabolic pathways are allocated at distinct points in the cell cycle. Overall, the research we propose will reveal fundamental links between cell growth, protein synthesis, and cell division, enabling novel therapeutic interventions in proliferative diseases.
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Coupling Of Protein Synthesis With Cell Division
  • 批准号:
    10792762
  • 项目类别:
  • 资助金额:
    $8.12万
  • 财政年份:
    2017
  • 负责人:
    MICHAEL S POLYMENIS
  • 依托单位:
Coupling of Protein Synthesis with Cell Division
  • 批准号:
    10593975
  • 项目类别:
  • 资助金额:
    $37.3万
  • 财政年份:
    2017
  • 负责人:
    MICHAEL S POLYMENIS
  • 依托单位:
Coupling of Protein Synthesis with Cell Division
  • 批准号:
    10210177
  • 项目类别:
  • 资助金额:
    $33.47万
  • 财政年份:
    2017
  • 负责人:
    MICHAEL S POLYMENIS
  • 依托单位:
Coordination of Cell Growth with Cell Division
  • 批准号:
    6384127
  • 项目类别:
  • 资助金额:
    $24.58万
  • 财政年份:
    2001
  • 负责人:
    MICHAEL S POLYMENIS
  • 依托单位:
海外基金