NRSA Training Core

NRSA 培训核心

• 批准号: 10653273
• 负责人: Joya Chandra
• 金额: $ 80.15万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-24 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10653273
• 关键词: Address; Admission activity; Area; Awareness; Big Data; Biomedical Research; Cancer Center; Clinical Sciences; Competence; Development; Discipline; Doctor of Medicine; Doctor of Philosophy; Entrepreneurship; Environment; Goals; Health Sciences; Individual; Informatics; Knowledge; Leadership; Medical center; Mentors; National Research Service Awards; Performance; Postdoctoral Fellow; Process; Research; Research Training; Resources; Science; Structure; Students; TNFSF15 gene; Texas; Training; Training Programs; Translational Research; Universities; Work; Workforce Development; career; career development; clinical center; doctoral student; faculty mentor; graduate school; health care delivery; interest; pre-doctoral; programs; skills; translational goal; translational pipeline

Contact PD/PI: McPherson, David D. NRSA-Training-001 (011) This TL1 Training Core, a part of Center for Clinical and Translational Sciences (CCTS) CTSA application, will provide 11 predoctoral PhD or MD/PhD students and 4 postdoctoral fellows annually with high-level and effective training in translational science. The major goal of this program is to provide high-level and effective training that promotes leadership in the translational sciences. TL1 trainees complete a competency-based training program that delivers a foundational understanding of the translational sciences as well as training in essential enrichment areas of career and professional development, including team science, leadership, entrepreneurship, and big data informatics/analytics. This training, with support for up to 2 years, promotes leadership in the translational sciences and contributes to workforce development of this field. Predoctoral trainees are appointed from the diverse student body of The University of Texas M. D. Anderson Cancer Center (UT MDACC) UTHealth Graduate School of Biomedical Sciences (UT-GSBS), a graduate school jointly administered and shared by The University of Texas Health Science Center at Houston (UTHSC-H) and UT MDACC. Postdoctoral trainees are appointed from both UTHSC-H and UT MDACC. This unique collaborative training environment is located in the Texas Medical Center, an extensive, world-class concentration of biomedical research and healthcare delivery. UT-GSBS students are admitted through an umbrella program where they receive fundamental knowledge in the biomedical sciences before branching out into discipline- specific programs offering in-depth research training. However, these discipline-specific programs do not provide a structured opportunity for trainees to gain knowledge and enrichment across the spectrum of translational sciences. This TL1 Training Core is focused on addressing this unmet need. Likewise, this program will provide postdoctoral fellows specialized training in translational sciences. TL1 trainees are selected by a competitive process that identifies promising individuals who show serious interest in translational research, have outstanding performance in coursework, and are mentored by faculty fully aware of the translational mission of the TL1 Core. Trainees are required to take courses and participate in enrichment activities that fulfill 11 targeted competencies that prepare them to rapidly integrate their skills into the clinical and translational sciences workforce. Extensive resources in the translational sciences, available through the CCTS, UTHSC-H, UT MDACC, and the Texas Regional CTSA Consortium, allow trainees to formulate personalized training programs that fit their research and career goals. All mentors are required to take Mentoring Works! Training to help align training and career development. Trainees who complete this program will have obtained specific skills to assist them in conducting collaborative science in the translational workforce.

联系PD/PI：麦克弗森，大卫D. NRSA-培训-001（011） 该TL 1培训核心是临床和转化科学中心（CCTS）CTSA申请的一部分，将 每年提供11名博士前博士或MD/博士生和4名博士后研究员， 有效的翻译科学培训。该计划的主要目标是提供高水平和有效的 培训，促进在转化科学的领导。TL 1学员完成基于能力的 培训计划，提供了一个基本的理解转化科学以及培训， 职业和专业发展的基本丰富领域，包括团队科学，领导力， 企业家精神和大数据信息学/分析。这种培训，支持长达2年，促进 在翻译科学的领导地位，并有助于该领域的劳动力发展。博士前 学员是从德克萨斯大学M。D.安德森癌症 中心（UT MDACC）UTHealth生物医学科学研究生院（UT-GSBS），研究生院联合 由德克萨斯大学休斯顿健康科学中心（UTHSC-H）和UT管理和共享 MDACC。博士后培训生由UTHSC-H和UT MDACC任命。这种独特的合作 培训环境位于德克萨斯州医疗中心，这是一个广泛的，世界级的集中地， 生物医学研究和医疗保健服务。UT-GSBS学生通过伞计划录取 在那里，他们在进入学科之前获得生物医学科学的基础知识， 提供深入研究培训的具体方案。然而，这些特定学科的计划并不 为学员提供一个结构化的机会，以获得知识和丰富的范围， 转化科学这个TL 1培训核心集中于解决这一未满足的需求。同样， 该计划将提供博士后研究员在翻译科学的专门培训。TL 1学员是 通过竞争过程选出，该过程确定了对以下领域表现出浓厚兴趣的有前途的个人 翻译研究，在课程中有出色的表现，并由教师充分意识到指导 TL 1核心的平移使命。学员须修读课程及参与 强化活动，实现11个目标能力，使他们能够快速将技能融入 临床和转化科学的劳动力。翻译科学的广泛资源，可用 通过CCTS，UTHSC-H，UT MDACC和德克萨斯州地区CTSA联盟，允许学员 制定适合他们的研究和职业目标的个性化培训计划。所有导师都必须 以指导工作！培训，以帮助调整培训和职业发展。完成本课程的学员 计划将获得特定的技能，以帮助他们在翻译中进行合作科学 劳动力

项目成果

Human Minor Salivary Glands: A Readily Available Source of Salivary Stem/Progenitor Cells for Regenerative Applications.

人类小唾液腺：用于再生应用的唾液干细胞/祖细胞的现成来源。

• DOI: 10.1007/978-1-0716-3609-1_3
• 发表时间: 2024
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Barrows,CaitlynnML;Wu,Danielle;Young,Simon;Farach-Carson,MaryC
• 通讯作者: Farach-Carson,MaryC

Clinical, molecular, metabolic, and immune features associated with oxidative phosphorylation in melanoma brain metastases.

• DOI: 10.1093/noajnl/vdaa177
• 发表时间: 2021-01
• 期刊: Neuro-oncology advances
• 作者: Fischer GM;Guerrieri RA;Hu Q;Joon AY;Kumar S;Haydu LE;McQuade JL;Vashisht Gopal YN;Knighton B;Deng W;Hudgens CW;Lazar AJ;Tetzlaff MT;Davies MA
• 通讯作者: Davies MA

Statistical process control to monitor use of a web-based autoplanning tool.

• DOI: 10.1002/acm2.13803
• 发表时间: 2022-12
• 期刊: JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
• 影响因子: 2.1
• 作者: Mehrens, Hunter;Douglas, Raphael;Gronberg, Mary;Nealon, Kelly;Zhang, Joy;Court, Laurence
• 通讯作者: Court, Laurence

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.

• DOI: 10.1038/s41467-024-44932-w
• 发表时间: 2024-01-25
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Hariharan, Seethalakshmi;Whitfield, Benjamin T.;Pirozzi, Christopher J.;Waitkus, Matthew S.;Brown, Michael C.;Bowie, Michelle L.;Irvin, David M.;Roso, Kristen;Fuller, Rebecca;Hostettler, Janell;Dharmaiah, Sharvari;Gibson, Emiley A.;Briley, Aaron;Mangoli, Avani;Fraley, Casey;Shobande, Mariah;Stevenson, Kevin;Zhang, Gao;Malgulwar, Prit Benny;Roberts, Hannah;Roskoski, Martin;Spasojevic, Ivan;Keir, Stephen T.;He, Yiping;Castro, Maria G.;Huse, Jason T.;Ashley, David M.
• 通讯作者: Ashley, David M.

Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma.

Sirtuin 2 抑制可调节全基因组染色质景观，从而诱导 ATRX 缺陷的恶性神经胶质瘤的衰老。

• DOI: 10.1093/neuonc/noad155
• 发表时间: 2024
• 期刊: Neuro-oncology
• 影响因子: 15.9
• 作者: Malgulwar,PritBenny;Danussi,Carla;Dharmaiah,Sharvari;Johnson,William;Singh,Anand;Rai,Kunal;Rao,Arvind;Huse,JasonT
• 通讯作者: Huse,JasonT