MEDSCAN: Mobile Enabled Diagnostics for Schistosomiasis Control Analytics

项目摘要 血吸虫病在54个国家流行，每年感染全世界近2.4亿人。次 撒哈拉非洲承受着不成比例的负担，占感染人数的90%以上。在肯尼亚， 根据我们的研究，全国五千万人口中有一千七百万人有感染血吸虫病的危险。的风险 在人口中，学龄儿童是主要的风险群体，许多感染的发病率是 在孩子的一生中被放大。 经过几十年的大规模药物管理，很明显，更积极和有针对性的干预措施， 这是消灭血吸虫病所必需的。不幸的是，这种认识还没有 导致了公共卫生官员实现这一转变所需的工具的发展。为了解决这个 针对这一未满足的需求，我们提出了开发MEDSCAN（移动的血吸虫病诊断系统 控制分析）平台，以改善血吸虫病监测工作。这个软件包建立在 我们在开发用于诊断的图像处理算法方面的成功历史 目的MEDSCAN将包括一个移动的应用程序，可以分析床旁诊断测试和一个 基于Web的管理员仪表板，用于查看实时运营性能指标和其他高级 分析学 我们已经组建了一个跨学科的联盟，由移动的健康软件和全球 范德比尔特大学的卫生专业知识，来自莱顿大学的血吸虫病诊断的世界领先者 医学中心，以及被忽视的热带病项目管理和领域的成功历史 肯尼亚医学研究所的研究。为了实现我们的共同目标，我们的具体目标将：1）评估 肯尼亚西部的蜂窝网络，为移动的健康研究做准备，并开发移动的和 web平台; 2）在平台上执行可用性分析并进行迭代改进; 3）完成 对MEDSCAN应用程序进行彻底的实验室评估和单点试验系统检查; 4）使用 在一项为期10个月的观察性监测研究中使用MEDSCAN平台。 通过将已经广泛使用的床旁检测转换为“连接”诊断，MEDSCAN可以 作为高分辨率监测的门户，这是将工作从控制转向消除所必需的。

PROJECT SUMMARY Schistosomiasis is endemic in 54 countries and infects nearly 240 million people worldwide per year. Sub- Saharan Africa endures a disproportionate burden, accounting for over 90% of infections. In Kenya, the site of our study, 17 million out of the nation’s 50 million citizens are at risk for schistosomiasis infection. Of the at-risk population, school-aged children represent the primary risk group, and the many morbidities of infection are amplified over a child’s lifespan. After decades of mass drug administration, it is clear that more aggressive and targeted interventions are necessary to move towards the elimination of schistosomiasis. Unfortunately, this recognition has not yet resulted in the development of the tools that public health officials need to make this transition. To address this unmet need, we propose the development of the MEDSCAN (mobile enabled diagnostics for schistosomiasis control analytics) platform to improve schistosomiasis surveillance efforts. This software package builds off of the successful history that we have had in the development of image-processing algorithms for diagnostic purposes. MEDSCAN will consist of a mobile application that can analyze point-of-care diagnostic tests and a web-based administrator dashboard for viewing real-time operational performance metrics and other advanced analytics. We have assembled an interdisciplinary consortium that consists of mobile health software and global health expertise at Vanderbilt University, a world-leader in schistosomiasis diagnostics from Leiden University Medical Center, and a successful history of neglected tropical disease program management and field research at the Kenya Medical Research Institute. To meet our shared goals, our specific aims will: 1) evaluate the cellular network in Western Kenya in preparation for mobile health research, and develop the mobile and web platforms; 2) perform a usability analysis on the platform and make iterative refinements; 3) complete a thorough laboratory evaluation of the MEDSCAN application and a single-site pilot systems check; 4) use the MEDSCAN platform in a 10-month, observational surveillance study. By transforming the already widely utilized point-of-care test into a “connected” diagnostic, MEDSCAN can serve as the gateway to high-resolution surveillance that is necessary to shift efforts from control to elimination.