Clinical Outcomes Research Training in Female Lower Urinary Tract Disorders

项目摘要 女性下尿路疾病，如尿失禁和尿路感染，是常见的 （每年影响数百万妇女），成本高，管理不佳。此外，研究不足 在这一领域进行，阻止新的和个性化的治疗和策略的发展，以优化 关怀和福祉。这部分是因为很少有医生和科学家接受过严格的研究这些问题的训练。 紊乱这个T32将有助于通过培训医学博士临床研究员和博士博士后研究员来满足这一需求， 成为女性下尿路疾病临床结局研究领域的领导者。具体而言是 这个华盛顿大学医学院T32计划的目的是：1）建立严格的招聘 和选择过程，以确定最有前途和多样化的研究为重点的MD和博士研究员; 2） 提供一个结构化但灵活的环境，让学员接受个性化的指导， 综合培训女性下尿路疾病的研究方法、伦理行为 研究和赠款写作; 3）提供财政支持和（保护）时间，让学员获得硕士学位 临床研究或人口健康科学学位，或临床结果相关课程 研究; 4）继续并加强现有的强有力的会议和教学系列，其中学员讨论 女性泌尿道疾病的当前临床主题和与这些疾病相关的研究方法; 5） 实施一个强有力的专业和职业发展计划，以促进受训人员过渡到 初级教师地位; 6）建立一个支持性的，反应迅速的，灵活的行政结构，以吸引和培养 最优秀的受训者，特别是妇女和代表性不足的少数民族;以及7）不断评估 并根据学员的需要改进方案。该计划将接受临床（MD，MD/PhD）和 博士后博士研究员长达三年的研究培训，由一个指导小组组成，至少 一名临床和一名方法学（临床结果）研究人员。至少有一个导师（主要）将 是一个资深研究员或临床医生谁是建立在他/她的领域，资助，并有一个很好的导师 业绩记录该计划的结构旨在促进跨学科和协作文化， 这些合作关系将在未来实现。为此，MD和PhD学员将 在每周的临床和研究会议以及职业和专业发展活动中团结起来。 研究员还可以选择进入硕士学位课程，以了解临床结果 研究方法，或提高他们现有的技能与特定的研究生水平的课程。此程序将 为下一代女性下尿路疾病的医学博士和博士研究人员做好准备， 高质量的临床结果研究，带来急需的方法学严谨性和协作，跨 对这一领域最紧迫的问题采取学科方法。

PROJECT SUMMARY Female lower urinary tract disorders, such as urinary incontinence and urinary tract infections, are common (affecting millions of women each year), costly, and sub-optimally managed. Additionally, insufficient research is performed in this area, preventing the development of new and personalized therapies and strategies to optimize care and well-being. This is, in part, because few physicians and scientists are trained to rigorously study these disorders. This T32 will help meet this need by training MD clinical fellows and PhD post-doctoral fellows to become leaders in the field of clinical outcomes research in female lower urinary tract disorders. Specifically, the aims of this Washington University School of Medicine T32 Program are to: 1) establish a rigorous recruitment and selection process to identify the most promising and diverse research-focused MD and PhD fellows; 2) provide a structured, yet flexible, environment in which trainees receive individualized mentoring and comprehensive training in female lower urinary tract disorders, research methods, the ethical conduct of research, and grant-writing; 3) provide financial support and (protected) time to allow trainees to obtain a Master’s degree in Clinical Investigation or Population Health Sciences, or relevant coursework in clinical outcomes research; 4) continue and augment a robust existing conference and didactic series in which trainees discuss current, clinical topics in female urinary tract disorders and research methods relevant to these disorders; 5) implement a robust professional and career development program tailored to enhance trainees’ transition to junior faculty status; 6) create a supportive, responsive, and flexible administrative structure to attract and nurture the most exceptional trainees, particularly women and under-represented minorities; and 7) continually evaluate and improve the Program in response to trainees’ needs. This Program will accept clinical (MD, MD/PhD) and post-doctoral PhD fellows for up to three years of research training by a mentoring team composed of at least one clinical and one methodologic (clinical outcomes) researcher. At least one of the mentors (the primary) will be a senior researcher or clinician who is established in his/her field, funded, and has an excellent mentorship track record. The Program structure is designed to foster a trans-disciplinary and collaborative culture, with the goal that these cooperative relationships will carry into the future. To that end, MD and PhD trainees will be united at weekly clinical and research conferences and in career and professional development activities. Fellows will also have the option of matriculating in a Master’s degree program to learn clinical outcomes research methods, or enhancing their existing skill set with specific graduate level courses. This program will prepare the next generation of MD and PhD researchers in female lower urinary tract disorders to perform high- quality clinical outcomes research, bringing much-needed methodologic rigor and a collaborative, trans- disciplinary approach to the most pressing questions in this field.