New insights into female reproductive tract formation and tubulogenesis.

对女性生殖道形成和肾小管发生的新见解。

• 批准号: DP240100491
• 负责人: A/Prof Craig Smith
• 金额: $ 35.21万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100491
• 关键词: New; insights; into; female; reproductive

Aims: This project aims to improve our understanding of female reproductive tract formation by studying its developmental origins. Most of the female reproductive tract derives from a pair of embryonic tubes called Müllerian ducts, the formation of which is incompletely understood. Significance: Using chicken and mouse models and innovative genetic approaches, the project will undercover novel genes and cellular pathways in Müllerian duct formation. Expected outcomes: This work will enhance knowledge in the biological sciences, in the area of female reproduction and how tubes form in biological systems. Benefits: It will train research scientists, develop collaborations and enhance Australia’s high standing in the field of reproduction.

目的：该项目旨在通过研究其发育起源来提高我们对女性生殖道的理解。大多数雌性生殖道源自一对称为müllerian管道的胚胎管，其形成未完全理解。意义：使用鸡肉和小鼠模型以及创新的遗传方法，该项目将在Müllerian管道形成中卧底新颖的基因和细胞途径。预期的结果：这项工作将增强生物学科学，女性繁殖领域以及生物系统中的管道形成的知识。好处：它将培训研究科学家，发展合作并增强澳大利亚在繁殖领域的高位。