New insights into female reproductive tract formation and tubulogenesis.

对女性生殖道形成和肾小管发生的新见解。

• 批准号: DP240100491
• 负责人: A/Prof Craig Smith
• 金额: $ 35.21万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100491
• 关键词: New; insights; into; female; reproductive

Aims: This project aims to improve our understanding of female reproductive tract formation by studying its developmental origins. Most of the female reproductive tract derives from a pair of embryonic tubes called Müllerian ducts, the formation of which is incompletely understood. Significance: Using chicken and mouse models and innovative genetic approaches, the project will undercover novel genes and cellular pathways in Müllerian duct formation. Expected outcomes: This work will enhance knowledge in the biological sciences, in the area of female reproduction and how tubes form in biological systems. Benefits: It will train research scientists, develop collaborations and enhance Australia’s high standing in the field of reproduction.

目的：本项目旨在通过研究女性生殖道的发育起源来提高我们对女性生殖道形成的认识。大多数女性生殖道来自一对胚胎管，称为苗勒管，其形成尚未完全了解。重要性：利用鸡和小鼠模型以及创新的遗传方法，该项目将揭示苗勒管形成中的新基因和细胞通路。预期成果：这项工作将增进生物科学、女性生殖领域以及管道如何在生物系统中形成的知识。好处：它将培训研究科学家，发展合作，提高澳大利亚在生殖领域的崇高地位。