Extraordinary Dispersion Engineering In Enabling Ultrafast Swept Source visiblelight Optical Coherence Tomography

非凡的色散工程实现超快扫频源可见光光学相干断层扫描

基本信息

批准号：
10698705
负责人：
Roman Kuranov
金额：
$ 25.3万
依托单位：
OPTICENT, INC.
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10698705
关键词：
Air Anatomy Architecture Biological Markers Biological Models Blindness Blood Blood Vessels Blood capillaries Calibration Caring Cattle Clinical Collaborations Coupling Dendrites Detection Disease Early Diagnosis Engineering Eye Fiber Frequencies Functional Imaging Future Glaucoma Goals Grant Hemoglobin Human Image Imaging technology Inner Plexiform Layer Interferometry Lasers Light Measures Mechanics Metabolic Morphologic artifacts Motion New York Noise Optic Nerve Optical Coherence Tomography Output Oxygen Patients Performance Phase Physiologic pulse Publishing Research Personnel Resolution Retina Retinal Ganglion Cells Signal Transduction Small Business Innovation Research Grant Source Speed Synapses System Technology Testing Theoretical model Thick Time Traction Training Tube Ultrafine Universities Visible Radiation Vision Visualization anatomic imaging arteriole charge coupled device camera clinical care cost design imaging capabilities imaging system improved interest meter nerve damage neural new product development next generation novel photonics preservation prevent prototype retinal imaging venule

项目摘要

Project Summary This SBIR Phase 1 project focuses on developing, characterizing, and validating a new swept-source laser system to enable the next-generation clinical visible-light optical coherence tomography (vis-OCT). We will develop a novel design of photonic bandgap fiber that comprises Fiber Bragg Grating array to temporally disperse broadband picosecond-pulses to create a wavelength sweeping pulse train. The new swept source can operate up to tens of MHz frequencies without mechanical moving parts, enabling ultra-high-speed swept-source vis-OCT (SS-vis-OCT) for the first time. The new light source will also enable truly shot-noise-limited performance in vis-OCT while mitigating the artifacts caused by both eye motions and fringe washout. During the project period, we will design, fabricate, and optimize the new swept-source laser to achieve the desired sweeping frequency, bandwidth, and phase stability. We will further develop a prototype SS-vis-OCT and fully test its performance in phantom eyeballs, ex vivo bovine eyes, and blood vessel phantoms.

项目摘要这个SBIR 1阶段项目的重点是开发，表征和验证新的扫描源激光器系统以实现下一代临床可见光光学相干断层扫描（VIS-OCT）。我们将开发一种新颖的光子带隙纤维的设计，该设计包括纤维Bragg Graging Array到时间分散宽带皮秒脉冲以创建波长扫描脉冲列。新的扫描源可以在没有机械运动部件的情况下运行多达数十个MHz频率第一次使用（SS-VIS-OCT）。新的光源还将实现真正的射击量有限的性能在vis-OCT中，同时减轻了眼动和边缘冲洗量引起的伪像。在项目期间时期，我们将设计，制造和优化新的扫描源激光器以实现所需的扫描频率，带宽和相位稳定性。我们将进一步开发一个原型SS-VIS-OCT并全面测试幻影眼球，离体牛眼和血管幻象的性能。