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Extraordinary Dispersion Engineering In Enabling Ultrafast Swept Source visiblelight Optical Coherence Tomography

非凡的色散工程实现超快扫频源可见光光学相干断层扫描

基本信息

批准号：
10698705
负责人：
Roman Kuranov
金额：
$ 25.3万
依托单位：
OPTICENT, INC.
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10698705
关键词：
Air Anatomy Architecture Biological Markers Biological Models Blindness Blood Blood Vessels Blood capillaries Calibration Caring Cattle Clinical Collaborations Coupling Dendrites Detection Disease Early Diagnosis Engineering Eye Fiber Frequencies Functional Imaging Future Glaucoma Goals Grant Hemoglobin Human Image Imaging technology Inner Plexiform Layer Interferometry Lasers Light Measures Mechanics Metabolic Morphologic artifacts Motion New York Noise Optic Nerve Optical Coherence Tomography Output Oxygen Patients Performance Phase Physiologic pulse Publishing Research Personnel Resolution Retina Retinal Ganglion Cells Signal Transduction Small Business Innovation Research Grant Source Speed Synapses System Technology Testing Theoretical model Thick Time Traction Training Tube Ultrafine Universities Visible Radiation Vision Visualization anatomic imaging arteriole charge coupled device camera clinical care cost design imaging capabilities imaging system improved interest meter nerve damage neural new product development next generation novel photonics preservation prevent prototype retinal imaging venule

项目摘要

Project Summary This SBIR Phase 1 project focuses on developing, characterizing, and validating a new swept-source laser system to enable the next-generation clinical visible-light optical coherence tomography (vis-OCT). We will develop a novel design of photonic bandgap fiber that comprises Fiber Bragg Grating array to temporally disperse broadband picosecond-pulses to create a wavelength sweeping pulse train. The new swept source can operate up to tens of MHz frequencies without mechanical moving parts, enabling ultra-high-speed swept-source vis-OCT (SS-vis-OCT) for the first time. The new light source will also enable truly shot-noise-limited performance in vis-OCT while mitigating the artifacts caused by both eye motions and fringe washout. During the project period, we will design, fabricate, and optimize the new swept-source laser to achieve the desired sweeping frequency, bandwidth, and phase stability. We will further develop a prototype SS-vis-OCT and fully test its performance in phantom eyeballs, ex vivo bovine eyes, and blood vessel phantoms.

项目摘要 SBIR第一阶段项目的重点是开发、表征和验证一种新的扫频光源激光器该系统能够实现下一代临床可见光光学相干断层扫描（vis-OCT）。我们将提出了一种新颖的光子带隙光纤设计，它包括光纤布拉格光栅阵列，分散宽带皮秒脉冲以产生波长扫描脉冲序列。新的扫频源可以工作频率高达数十MHz，无需机械运动部件，可实现超高速扫频源首次使用vis-OCT（SS-vis-OCT）。新光源还将实现真正的散粒噪声限制性能在vis-OCT中，同时减轻由眼睛运动和条纹冲刷引起的伪影。在项目在此期间，我们将设计、制造和优化新的扫频源激光器，以实现所需的扫频频率、带宽和相位稳定性。我们将进一步开发一个原型SS-vis-OCT，并全面测试其在体模眼球、离体牛眼和血管体模中的性能。