Extraordinary Dispersion Engineering In Enabling Ultrafast Swept Source visiblelight Optical Coherence Tomography

项目摘要 SBIR第一阶段项目的重点是开发、表征和验证一种新的扫频光源激光器 该系统能够实现下一代临床可见光光学相干断层扫描（vis-OCT）。我们将 提出了一种新颖的光子带隙光纤设计，它包括光纤布拉格光栅阵列， 分散宽带皮秒脉冲以产生波长扫描脉冲序列。新的扫频源可以 工作频率高达数十MHz，无需机械运动部件，可实现超高速扫频源 首次使用vis-OCT（SS-vis-OCT）。新光源还将实现真正的散粒噪声限制性能 在vis-OCT中，同时减轻由眼睛运动和条纹冲刷引起的伪影。在项目 在此期间，我们将设计、制造和优化新的扫频源激光器，以实现所需的扫频 频率、带宽和相位稳定性。我们将进一步开发一个原型SS-vis-OCT，并全面测试其 在体模眼球、离体牛眼和血管体模中的性能。

Project Summary This SBIR Phase 1 project focuses on developing, characterizing, and validating a new swept-source laser system to enable the next-generation clinical visible-light optical coherence tomography (vis-OCT). We will develop a novel design of photonic bandgap fiber that comprises Fiber Bragg Grating array to temporally disperse broadband picosecond-pulses to create a wavelength sweeping pulse train. The new swept source can operate up to tens of MHz frequencies without mechanical moving parts, enabling ultra-high-speed swept-source vis-OCT (SS-vis-OCT) for the first time. The new light source will also enable truly shot-noise-limited performance in vis-OCT while mitigating the artifacts caused by both eye motions and fringe washout. During the project period, we will design, fabricate, and optimize the new swept-source laser to achieve the desired sweeping frequency, bandwidth, and phase stability. We will further develop a prototype SS-vis-OCT and fully test its performance in phantom eyeballs, ex vivo bovine eyes, and blood vessel phantoms.