Hand-held advanced functional imager for assessing local tissue oxygenation

用于评估局部组织氧合的手持式高级功能成像仪

• 批准号: 8881787
• 负责人: Roman Kuranov
• 金额: $ 15万
• 依托单位: WASATCH PHOTONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8881787
• 关键词: 3-Dimensional; Adhesions; Advanced Development; Anatomy; Angiography; Animal Model; Area; Biological Markers; Blood; Blood Transfusion; Blood Vessels; Blood flow; Caliber; Clinical; Code; Color; Communicable Diseases; Consumption; Decision Making; Devices; Diffuse; Discrimination; Disease; Erythrocyte Transfusion; Erythrocytes; Etiology; Evaluation; Eye; Hand; Hemoglobin; Hospitals; Image; Imaging technology; Immune; Immune System Diseases; Inflammatory; Injury; Inpatients; Lead; Letters; Location; Lung; Malignant - descriptor; Maps; Market Research; Marketing; Measurement; Measures; Mechanics; Methods; Microcirculation; Modality; Modeling; Modification; Monitor; Morbidity - disease rate; Mus; Nature; Near-Infrared Spectroscopy; Optical Coherence Tomography; Outcome; Oxygen; Oxygen Consumption; Patients; Performance; Phase; Physicians; Positioning Attribute; Procedures; Property; Recurrence; Relative (related person); Resolution; Risk; Scanning; Skeletal Muscle; Small Business Innovation Research Grant; Social Impacts; Spectrum Analysis; Technology; Testing; Time; Tissues; Transfusion; Uncertainty; Universities; absorption; abstracting; arteriole; clinically relevant; commercialization; cost effective; data acquisition; design; digital; improved; in vivo; indexing; innovation; innovative technologies; instrument; interest; mortality; photonics; portability; prototype; public health relevance; quantitative imaging; spectrograph; spectroscopic imaging; tissue oxygenation; tissue phantom; tool; venule

 DESCRIPTION (provided by applicant): We propose development of an advanced functional imager to assess red blood cell (RBC) transfusion. The prototype will be tested in a functional phantom during this SBIR Phase I project. The key features of the imager are the ability to quantify local tissue oxygenation with a handheld probe for easy tissue access. Our preliminarily market research indicates a strong demand for such instrument to help physicians effectively perform RBC transfusion, which is the most common inpatient hospital procedure. We hypothesize that non-invasive technology capable of providing repeated 3-D functional maps of tissue microvessels with diameters between 20-50 µm, where oxygen starts diffusing to the parenchymal tissues, will significantly decrease morbidity and mortality in RBC transfusion. Such technology has the potential to guide procedures by providing favorable information about optimal transfusion threshold, as well as evaluation of RBCs degradation with storage time and conditions. Current imaging technologies used to assess RBC transfusion include: Sidestream Dark Field (SDF), Orthogonal Polarization Spectral (OPS) and Near Infrared Spectroscopy (NIRS) do not provide 3-D maps of microvascular blood oxygenation and flow in a single microvessel with diameter 20-50 µm. SDF and OPS provide 2-D non-depth-resolved angiography and blood flow microvasculature information, thus missing the oxygenation information and arterioles and venules discrimination. The NIRS provides average arterial oxygenation information from a few square mm area and thus misses oxygen extraction, blood flow and spatial resolution. We propose to fill this gap with the proposed imaging technology for RBC transfusion assessment by combining multifunctional optical coherence tomography (OCT) and OPS in a single hand- held device. OPS offers real-time 2-D microvasculature map for user guidance purposes while multifunctional OCT provides 3-D microvasculature angiography and maps of blood flow and hemoglobin oxygen (O2) saturation (SO2) in single arterioles and venules as well as O2 extraction and relative oxygen consumption. We believe our approach provides the needed performance to solve a critical problem and a clear path to successful commercialization. This project will have strong social impact by providing critical clinical information to improve patient outcomes. Quantitative imaging of local tissue oxygen delivery and consumption will not only improve RBC transfusion outcome but has a great potential to decrease morbidity and mortality in many devastating diseases with vascular etiology including a variety of malignant, inflammatory, ischemic, infectious and immune disorders.

 描述（由申请人提供）：我们建议开发一种先进的功能成像仪，以评估红细胞（RBC）输注。在SBIR第I阶段项目期间，将在功能体模中对原型进行测试。该成像仪的主要特点是能够用手持式探头量化局部组织氧合，便于组织进入。我们的初步市场调查表明，对这种仪器的强烈需求，以帮助医生有效地进行红细胞输注，这是最常见的住院手术。我们假设，能够提供直径在20-50 µm之间的组织微血管（氧气开始扩散到实质组织）的重复三维功能图的非侵入性技术将显著降低RBC输注的发病率和死亡率。这种技术有可能通过提供有关最佳输血阈值的有利信息以及评价RBC随储存时间和条件的降解来指导程序。 目前用于评估红细胞输注的成像技术包括：侧流暗场（SDF）、正交偏振光谱（OPS）和近红外光谱（NIRS）不能提供直径为20-50 µm的单个微血管中微血管血氧和血流的3D图。SDF和OPS提供了2-D非深度分辨血管造影和血流微血管信息，因此丢失了氧合信息和小动脉和小静脉区分。NIRS提供了几平方毫米区域的平均动脉氧合信息，因此错过了氧提取、血流和空间分辨率。我们建议通过将多功能光学相干断层扫描（OCT）和OPS结合在一个手持式设备中，使用所提出的用于RBC输血评估的成像技术来填补这一空白。OPS提供实时2-D微血管图用于用户指导目的，而多功能OCT提供3-D微血管造影和单个小动脉和小静脉中的血流和血红蛋白氧（O2）饱和度（SO2）图以及O2提取和相对耗氧量。我们相信，我们的方法提供了解决关键问题所需的性能，并为成功的商业化提供了清晰的道路。 该项目将通过提供关键临床信息来改善患者结局，从而产生强大的社会影响。局部组织氧输送和消耗的定量成像不仅将改善RBC输注结果，而且具有降低许多具有血管病因的破坏性疾病（包括各种恶性、炎症、缺血性、感染性和免疫性疾病）的发病率和死亡率的巨大潜力。