Project 1: The impact of sleep dysregulations on Autism Spectrum Disorder
项目1:睡眠失调对自闭症谱系障碍的影响
基本信息
- 批准号:10698070
- 负责人:
- 金额:$ 39.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-06 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAgeAnimal ExperimentsAnimal ModelAnimalsBehaviorBrainCaregiversChildCircadian RhythmsCognitionCognitiveCollaborationsCommunicationDataDevelopmentElectroencephalographyElectrophysiology (science)EtiologyExhibitsFrequenciesGenderGenetic ModelsHomeHome environmentHumanImpairmentInvestigationKnock-outKnockout MiceLaboratoriesLinkMeasuresMeta-AnalysisModelingNeuronsParentsParticipantPathologyPatternPhysiologyPilot ProjectsPolysomnographyREM SleepRattusReportingRestSample SizeSamplingSeveritiesSleepSleep ArchitectureSleep DeprivationSleep FragmentationsSleep disturbancesSlow-Wave SleepStereotyped BehaviorSymptomsSynapsesSynaptic plasticityTestingWakefulnessactigraphyautism spectrum disorderautistic childrenawakebehavior measurementcognitive functiondensityexperiencefrontal lobegray matterimprovedindividuals with autism spectrum disordermyelinationneurodevelopmentrepetitive behaviorsexsleep onsetsleep qualitysocialsocial cognitionsocial communicationtrait
项目摘要
The impact of sleep dysregulation on Autism Spectrum Disorder: Abstract
As many as 80% of children with Autism Spectrum Disorder (ASD) experience sleep disruptions. These
are among the most burdensome symptoms reported by parents of children with ASD. Insufficient
subjective sleep quality is associated with exacerbated severity of core ASD symptoms, including
repetitive behaviors, social and communication difficulties. However, the few objective sleep PSG
studies have not found significant effects. This likely reflects the small number of studies that utilized
PSG as an objective sleep measure, small sample sizes, or assessment in a laboratory setting rather
than in the child's home environment. Our own investigation of a larger sample using sleep PSG in
ASD subjects, in their home, found an increased SWS ratio in ASD and a lower REM sleep ratio
compared to typically developing (TD) children and adolescents. To address the critical question of
whether dysregulated sleep is central to the development and symptoms of ASD, we will test for
differences in sleep fragmentation (actigraphy), sleep architecture (PSG) and daytime, awake, resting
state EEG, in 150 individuals with ASD and 75 age and sex-matched TD controls, age 4-17. We will
examine if any observed sleep dysregulation is associated with the core symptoms, repetitive
behaviors, and cognitive function of ASD. We will also examine if sleep impairments are associated
with dysregulated daytime, resting state EEG in ASD compared to TD. In collaboration with Project 2,
we will examine if target engagement-induced normalization of sleep positively impacts these
symptoms. In collaboration with Projects 3 and 4, we will examine if the hypothesized impairments in
sleep fragmentation, sleep architecture and daytime awake, resting state EEG in ASD will be
recapitulated in our animal experiments of sleep in genetic models of ASD and if normalization of sleep
fragmentation, sleep architecture and daytime awake, resting EEG in our animal models of ASD will be
associated with improved social communication and cognition, and reduced repetitive behaviors in
these animal models. If we demonstrate that sleep fragmentation is responsible for the development of
some ASD traits and sleep normalization alleviates them, we will have demonstrated the potential
causality and importance of sleep in ASD.
睡眠失调对自闭症谱系障碍的影响
多达80%的自闭症谱系障碍(ASD)儿童经历过睡眠中断。这些
是自闭症儿童父母报告的最沉重的症状之一。不足
主观睡眠质量与ASD核心症状的加重有关,包括
重复的行为、社交和沟通困难。然而,为数不多的客观睡眠PSG
研究还没有发现显著的影响。这可能反映了少数研究利用了
PSG作为一种客观的睡眠测量、小样本量或实验室环境中的评估
而不是在孩子的家庭环境中。我们自己使用睡眠PSG对更大样本进行的研究
ASD受试者在家中发现ASD患者的SWS比率增加,REM睡眠比率降低
与典型的发育中(TD)儿童和青少年相比。要解决……的关键问题
睡眠失调是否是ASD的发展和症状的核心,我们将测试
睡眠碎片(活动图)、睡眠结构(PSG)和白天、清醒、休息的差异
对150名ASD患者和75名年龄和性别匹配的TD对照组(年龄4-17岁)进行状态脑电检查。我们会
检查任何观察到的睡眠失调是否与重复出现的核心症状有关
ASD的行为和认知功能。我们还将检查睡眠障碍是否与
与TD组比较,ASD组白天异常、静息状态EEG改变更明显。与项目2合作,
我们将研究目标参与诱导的睡眠正常化是否对这些
症状。与项目3和项目4合作,我们将检查假设的减值是否在
ASD患者的睡眠碎片、睡眠结构和日间清醒、静息状态脑电
在ASD基因模型和睡眠正常化的动物实验中概述了睡眠
在我们的ASD动物模型中,碎片、睡眠结构和白天清醒、休息的脑电将是
与改善社会沟通和认知以及减少重复的行为有关
这些动物模型。如果我们证明睡眠碎片化是导致
一些ASD特征和睡眠正常化可以缓解它们,我们将展示这种潜力
睡眠在ASD中的因果关系和重要性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ruth M O'Hara其他文献
Ruth M O'Hara的其他文献
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{{ truncateString('Ruth M O'Hara', 18)}}的其他基金
Project 1: The impact of sleep dysregulations on Autism Spectrum Disorder
项目1:睡眠失调对自闭症谱系障碍的影响
- 批准号:
10531474 - 财政年份:2022
- 资助金额:
$ 39.39万 - 项目类别:
Stanford Center for Clinical & Translational Education and Research (Spectrum)
斯坦福临床中心
- 批准号:
10261915 - 财政年份:2020
- 资助金额:
$ 39.39万 - 项目类别:
Stanford Center for Clinical & Translational Education and Research (Spectrum)
斯坦福临床中心
- 批准号:
10221072 - 财政年份:2019
- 资助金额:
$ 39.39万 - 项目类别:
Stanford Center for Clinical & Translational Education and Research (Spectrum)
斯坦福临床中心
- 批准号:
9978163 - 财政年份:2019
- 资助金额:
$ 39.39万 - 项目类别:
Stanford Center for Clinical & Translational Education and Research (Spectrum)
斯坦福临床中心
- 批准号:
10664842 - 财政年份:2019
- 资助金额:
$ 39.39万 - 项目类别:
Stanford Center for Clinical & Translational Education and Research (Spectrum)
斯坦福临床中心
- 批准号:
10438815 - 财政年份:2019
- 资助金额:
$ 39.39万 - 项目类别:
Stanford Center for Clinical & Translational Education and Research (Spectrum)
斯坦福临床中心
- 批准号:
9903514 - 财政年份:2019
- 资助金额:
$ 39.39万 - 项目类别:
MELATONIN AND COGNITION IN MILD COGNITIVE IMPAIRMENT (MCI)
褪黑激素与轻度认知障碍 (MCI) 中的认知
- 批准号:
7605232 - 财政年份:2007
- 资助金额:
$ 39.39万 - 项目类别:
MELATONIN AND COGNITION IN MILD COGNITIVE IMPAIRMENT (MCI)
褪黑激素与轻度认知障碍 (MCI) 中的认知
- 批准号:
7717885 - 财政年份:2007
- 资助金额:
$ 39.39万 - 项目类别:
MCI, APOE and Sleep Apnea: Effects on Cognition
MCI、APOE 和睡眠呼吸暂停:对认知的影响
- 批准号:
7383172 - 财政年份:2005
- 资助金额:
$ 39.39万 - 项目类别:
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