Immune and neuroendocrine mediators of sex-differences in pain following traumatic burn injury

创伤性烧伤后疼痛性别差异的免疫和神经内分泌介质

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT Traumatic burn injuries generate excruciating pain resulting from tissue and nerve damage and the accompanying exaggeration of inflammation. Necessary wound care procedures such as debridement, burn excision, grafting, and mobilization only add to this pain. For these reasons, pain from traumatic burn injury is notoriously difficult to manage; hence current reports suggest that burn-related pain is currently undertreated. Traumatic injuries have a dramatic increase in pain sensitivity (hyperalgesia) and accelerated development of tolerance to opioid analgesics compared with non-traumatic injuries. Unfortunately, the mechanisms driving increased sensitivity and tolerance following trauma are unclear. Furthermore, over half of all burn survivors develop chronic pain, making the transition from acute to chronic pain a significant concern following burn injury. Research has primarily focused on the innate immune response to injury as a leading candidate; however, the recent inclusion of female subjects has uncovered sex-specific differences in immune-modulated pain sensitivity. These findings have led to reconsideration of the influence of sex on pain processing and whether the body of male-only research is truly applicable. It is well known that females are more likely to report more severe pain and to experience chronic pain following such injuries; however, the mechanisms behind these sex-specific differences are currently unknown. Additionally, stress-induced adaptations in the neuroendocrine system are believed to play an essential role in the pathogenesis of acute and chronic pain outcomes. Dysregulation of the hypothalamic-pituitary-adrenal and sympathoadrenal axes following traumatic injury has been shown to reduce the activity of descending pathways that modulate endogenous pain inhibition and opioid analgesia. We hypothesize that the immune response involved in the pathogenesis of pain following traumatic burn injury is regulated in a sex-specific manner through involvement of the neuroendocrine system. Exploiting these sex- specific differences may be key to understanding how to treat pain generated from traumatic burn injuries. Sex- specific genes, hormones, and signaling mechanisms may shed light on novel targets that have been previously overlooked, giving great hope for future sex-specific interventions. Accordingly, the proposed research program will address this critical gap in our understanding by systematically investigating the role of sex-specific immune reactivity and neuroendocrine responses in an animal model of full-thickness thermal burn injury. This program of research will lead us closer to understanding mechanisms that make pain from traumatic burn injuries so challenging to treat and identify sex-related drivers behind them. Our goal over the duration of this award is to identify sex-specific mechanisms underlying the accelerated development of tolerance and hyperalgesia and to provide insight to potential targets for sex-specific interventions to treat acute pain and prevent the transition to chronic pain. Conduct of these studies will build a robust program of research positioned to investigate any promising targets we may uncover.
项目总结/文摘

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jennifer E. Nyland其他文献

Cannabidiol-Derived Cannabinoids: The Unregulated Designer Drug Market Following the 2018 Farm Bill
大麻二酚衍生的大麻素:2018 年农业法案之后不受监管的设计药物市场
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    C. N. Zawatsky;Sara Mills;Corinne M. Augusto;Kent E Vrana;Jennifer E. Nyland
  • 通讯作者:
    Jennifer E. Nyland
Correction: The relationship between police contacts for drug use‑related crime and future arrests, incarceration, and overdoses: a retrospective observational study highlighting the need to break the vicious cycle
  • DOI:
    10.1186/s12954-022-00669-7
  • 发表时间:
    2022-07-29
  • 期刊:
  • 影响因子:
    4.000
  • 作者:
    Alice Zhang;Joseph A. Balles;Jennifer E. Nyland;Thao H. Nguyen;Veronica M. White;Aleksandra E. Zgierska
  • 通讯作者:
    Aleksandra E. Zgierska
Lesions of the thalamic trigeminal taste area dissociate natural from drug reward
丘脑三叉神经味觉区的病变将自然与药物奖励分离
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    5.4
  • 作者:
    Jennifer E. Nyland;Nu Chu Liang;R. Norgren;P. S. Grigson
  • 通讯作者:
    P. S. Grigson
Law enforcement-led, pre-arrest diversion-to-treatment may reduce crime recidivism, incarceration, and overdose deaths: Program evaluation outcomes
  • DOI:
    10.1016/j.josat.2024.209458
  • 发表时间:
    2024-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jennifer E. Nyland;Alice Zhang;Joseph A. Balles;Thao H. Nguyen;Veronica White;Laura A. Albert;Mary F. Henningfield;Aleksandra E. Zgierska
  • 通讯作者:
    Aleksandra E. Zgierska
71 - Characterizing The Inflammatory and Behavioral Consequences of Peripheral Nerve Injury
71 - 表征周围神经损伤的炎症和行为后果
  • DOI:
    10.1016/j.jpain.2025.104867
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    4.000
  • 作者:
    Corinne M. Augusto;Nikhil K. Acharya;Andras Hajnal;Nelli Horvath;Cole Moran-Bariso;Jennifer E. Nyland
  • 通讯作者:
    Jennifer E. Nyland

Jennifer E. Nyland的其他文献

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{{ truncateString('Jennifer E. Nyland', 18)}}的其他基金

Immune and neuroendocrine mediators of sex-differences in pain following traumatic burn injury
创伤性烧伤后疼痛性别差异的免疫和神经内分泌介质
  • 批准号:
    10789498
  • 财政年份:
    2022
  • 资助金额:
    $ 40.59万
  • 项目类别:
Role of the Trigeminal Orosensory Area of the Thalamus in Natural and Drug Reward
丘脑三叉神经口感觉区在自然和药物奖赏中的作用
  • 批准号:
    8265862
  • 财政年份:
    2011
  • 资助金额:
    $ 40.59万
  • 项目类别:
Role of the Trigeminal Orosensory Area of the Thalamus in Natural and Drug Reward
丘脑三叉神经口感觉区在自然和药物奖赏中的作用
  • 批准号:
    8127420
  • 财政年份:
    2011
  • 资助金额:
    $ 40.59万
  • 项目类别:

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