Effect of dietary restriction and exercise on behavioral outcomes and brain pathology in a transgenic model of Alzheimer's disease

项目总结：会堂项目 阿尔茨海默氏症(AD)是我们这个时代最具破坏性的疾病之一；有近600万人被诊断出 它是导致老年人死亡的第三大原因。在寻找治愈方法的竞赛中，有一件事是肯定的--节食 运动可以降低风险。然而，降低风险的机制尚不清楚。几个 研究已经将饮食限制和锻炼与改善记忆力、减少淀粉样β蛋白斑块以及 Tau蛋白在AD中相互纠缠。该项目将评估间歇性禁食(IF)，一种流行的饮食方法 在一种新的模型中，限制和运动结合使用是神经保护的 AD，TgF344-AD转基因大鼠。这个项目的目标有三个。1)确定是否具有保护性 对TgF344-AD大鼠行为结果(记忆力、协调性和力量)的影响。2)确定是否 运动与IF相结合可提供额外的保护。3)评估如果独立和 结合AD病理和感兴趣的保护途径的运动。这个项目将导致一个 揭示IF在TgF344-AD动物和项目中对脑和骨骼肌组织的影响 为未来研究这种毁灭性的药物治疗建立一条保护途径 疾病。

PROJECT SUMMARY: HALL PROJECT Alzheimer’s Disease (AD) is one of the most devastating diseases of our time; with nearly 6 million diagnosed it ranks as the third leading cause of death among older adults. In the race for a cure one thing is certain—diet and exercise reduce risks. However, the mechanisms responsible for the reduced risks are unknown. Several studies have linked dietary restriction and exercise to improved memory, reduced amyloid beta plaques, and tau protein tangles in AD. This project will evaluate if intermittent fasting (IF), a popular method of dietary restriction, administered independently and in combination with exercise, is neuroprotective in a novel model of AD, the TgF344-AD transgenic rat. The aims of this project are three-fold. 1) To characterize IF protective effects on behavioral outcomes (memory, coordination, and strength) in the TgF344-AD rat. 2) To determine if exercise provides additional protection when combined with IF. 3) To assess the effects of IF independent and in combination with exercise on AD pathology and protective pathways of interest. This project will result in an unveiling of the effect of IF in the brain and skeletal muscles tissue in the TgF344-AD animal and project could establish a pathway of protection for future research into pharmacological treatment of this devastating disease.