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Optimizing Clinical Trial Endpoints in Frontotemporal Dementia

优化额颞叶痴呆的临床试验终点

基本信息

批准号：
10660926
负责人：
Adam Mark Staffaroni
金额：
$ 17.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10660926
关键词：
Address Affect Age Age of Onset Aging Algorithms Atrophic Biological Markers Biometry California Characteristics Clinical Clinical Research Clinical Trials Clinical Trials Design Clinical dementia rating scale Cognition Cohort Studies Complex Conduct Clinical Trials Cost Effectiveness Analysis Data Dedications Dementia Development Diffusion Disease Disease model Drug Targeting Education Enrollment Environment Etiology Face Family Frontotemporal Dementia Frontotemporal Lobar Degenerations Functional disorder Future Genetic Genotype Goals Health Policy Heterogeneity Image Inherited K-Series Research Career Programs Knowledge Light Liquid substance Longitudinal Studies Measures Memory Mentors Mentorship Methodology Methods Modality Molecular Multicenter Studies Mutation Nerve Degeneration Neurodegenerative Disorders Neurologist Neurology Neuropsychology Outcome Outcome Measure Patient Selection Patients Pattern Pharmaceutical Preparations Phenotype Pre-Clinical Model Prevention trial Primary Progressive Aphasia Proteins Public Health Research Research Personnel Resources Risk Sample Size San Francisco Semantics Specific qualifier value Symptoms Syndrome Techniques Time Training Translating Universities Variant Work autosome behavioral variant frontotemporal dementia biological heterogeneity clinical center clinical heterogeneity clinical outcome measures clinical phenotype clinical predictors cost effective drug development early onset gray matter improved longitudinal analysis multimodal data multimodal neuroimaging multimodality neurofilament neuroimaging neuroimaging marker novel novel strategies participant enrollment perfusion imaging personalized approach predictive modeling prevent professor prognostication programs protein TDP-43 targeted agent tau Proteins treatment optimization treatment trial

项目摘要

PROJECT SUMMARY In this K23 career development award, Dr. Adam Staffaroni will obtain training in clinical trial design, advanced biostatistics, and multimodal neuroimaging to improve clinical trial endpoints for frontotemporal dementia (FTD). Dr. Staffaroni is an Assistant Professor of Neurology and neuropsychologist at the University of California, San Francisco’s (UCSF) Memory and Aging Center (MAC). His long-term goal is to become a leading clinical researcher in neurodegenerative disease, establishing a lab that develops new approaches to clinical trials, through deep phenotyping and integrating individualized biomarkers. Through the support of this K23 and the vibrant, interdisciplinary training environment and enriched resources at the MAC, Dr. Staffaroni aims to accomplish the following training goals: 1) obtain training in clinical trials methodology, 2) deepen his knowledge of advanced biostatistics and neuropsychological assessment, 3) gain expertise in multimodal neuroimaging biomarkers of neurodegeneration, and 4) translate the K23 training and findings into an R01 that validates efficient approaches to clinical trial design. To achieve these goals, Dr. Staffaroni has assembled an exemplary mentorship team, including his primary mentor, Dr. Howard Rosen, a neurologist and expert in neuroimaging biomarkers of neurodegeneration; co-mentor Dr. Adam Boxer, a professor of neurology and director of the UCSF MAC’s Clinical Trials Program; co-mentor Dr. Joel Kramer, a neuropsychologist with decades of research dedicated to quantifying cognition in aging and dementia; collaborator Dr. John Kornak, a biostatistician who is renowned for his work on longitudinal and data-driven analyses; collaborator, Dr. Jennifer Yokoyama, a geneticist who focuses on the genetic contributions to neurodegeneration; and collaborator Dr. James G. Kahn, a professor of Health Policy and expert in cost-effectiveness analysis. The central premise of this project is that FTD is a model disease to develop treatments for neurodegeneration, but clinical trials face the challenge of accommodating the significant phenotypic heterogeneity associated with FTD. The overarching goal of this study is to optimize treatment trials by improving enrollment strategies and developing methods for selecting precise outcome measures. This project will improve enrollment strategies by creating baseline risk scores that incorporate several modalities of biomarkers, such as neuroimaging, genetic, and fluid biomarkers. Individualized, cost-effective risk scores would allow clinical trials to stratify or enroll patients who would maximize the likelihood of detecting a drug effect. We will also predict symptom onset in presymptomatic carriers of autosomal dominant FTD mutations; prediction of conversion would allow treatment and prevention trials to target the earliest stages of disease. Finally, we will develop an algorithm that leverages baseline patient characteristics to choose individualized trial endpoints. This is imperative for addressing the significant clinical heterogeneity associated with FTD, which renders traditional “one-size-fits-all” endpoints unable to sensitively detect clinically meaningful changes.

项目总结