Gaze, Head Rotation, and Neuroanatomic Correlates of Reading Errors in Neglect Dyslexia

忽视阅读障碍中阅读错误的凝视、头部旋转和神经解剖学相关性

• 批准号: 10658715
• 负责人: Timothy John Rich
• 金额: $ 12.54万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658715
• 关键词: Activities of Daily Living; Affect; American; Applied Research; Area; Arousal; Attention; Basic Science; Behavior; Behavioral; Bilateral; Biometry; Brain; Brain Mapping; Brain scan; Classification; Clinical assessments; Cognition; Data; Detection; Diagnosis; Dorsal; Dyslexia; Etiology; Eye; Eye Movements; Face; Functional disorder; Funding; Goals; Head; Impairment; Individual; Intervention; Left; Leisures; Lesion; Letters; Literature; Location; Maps; Measures; Mentored Research Scientist Development Award; Modeling; National Institute of Child Health and Human Development; Neuroanatomy; Neurologic; Neuropsychology; Neurosciences Research; Outcome; Participant; Patients; Pattern; Play; Population; Positioning Attribute; Predictive Value; Reader; Reading; Reading Disorder; Rehabilitation therapy; Research; Role; Rotation; Side; Stimulus; Stroke; Symptoms; Technology; Training; United States National Institutes of Health; Visuospatial; Work; behavior test; cognitive neuroscience; experience; experimental study; functional gain; functional independence; gaze; improved; innovation; interest; neglect; nerve injury; neural network; neuroimaging; neurological rehabilitation; novel; post stroke; rehabilitation science; spatial neglect; stroke survivor; support network; treatment response; vigilance; virtual reality environment; visual stimulus; visual tracking

PROJECT SUMMARY/ABSTRACT Neglect dyslexia (ND) is an acquired reading disorder associated with spatial neglect (SN), commonly experienced by right hemisphere stroke survivors. ND causes whole-word omissions of left-sided words and errors on the left-sided letters of individual words (unilateral paralexias). These two distinct error types can be explained by dysfunctional egocentric (i.e., viewer-centered) and allocentric (i.e., object-centered) spatial cognition, respectively. Gaze asymmetry has long been considered a hallmark symptom of SN, and recent research suggests that it might contribute to these errors. However, no study to date has directly correlated gaze and reading in this population. Gaze involves the coordination of the head and eyes to orient toward a target. However, most gaze-related research in SN and ND thus far has required the head to be stabilized at midline. Therefore, relative contributions of the head and eyes to the asymmetry of gaze in SN and ND is unknown. Current neuroanatomical models of SN and ND suggest that it is caused by disruptions to the interaction of a bilateral dorsal attention network, which subserves spatial attention and eye movements, and a unilateral right hemisphere ventral attention network, which supports arousal, vigilance, detection of novel stimuli, and reorienting attention to novel stimuli. It is unknown how a network disruption leads to a specific type of ND. In this project, we will examine the predictive value of gaze on ND reading errors, the relative contributions of the head and eyes to gaze orientation, and the disrupted neural networks that underlie specific gaze patterns and egocentric and allocentric ND error patterns. (1) To characterize the association between gaze and reading, we will conduct two experiments that measure gaze with a wearable eye tracker during single-word reading. We expect to find a strong correlative relationship between gaze accuracy and reading accuracy in participants with ND, which would support the potential for the use of gaze metrics for ND diagnosis and classification. (2) To determine the relative contributions of the head and eyes to gaze deficits, we will conduct an experiment using eye tracking-enabled immersive virtual reality to measure gaze while manipulating the effect of head rotation. We expect participants with a greater contribution of the head to have poorer egocentric gaze toward left-sided words and more whole-word omissions. (3) To identify the neural networks that underlie gaze asymmetry and reading errors, we will lesion map brain scans of participants with and without ND, then use voxel-wise lesion- symptom mapping to correlate the degree of lesioned brain areas to gaze accuracy and reading accuracy. We anticipate that lesions disrupting the dorsal network impair egocentric gaze orientation and associate with whole- word omissions, and that lesions disrupting the ventral network impair allocentric gaze orientation and associate with unilateral paralexias.

项目摘要/摘要 忽视阅读障碍（ND）是一种与空间忽视相关的获得的阅读障碍（SN），通常是 右半球中风幸存者经历。 nd导致左侧单词的全词遗漏和 左侧字母的错误单词（单侧帕拉西亚）。这两种不同的错误类型可以是 用功能失调的自我中心（即以观看者为中心）和中心（即以对象为中心的）空间 认知分别。凝视不对称长期以来一直被认为是SN的标志性症状，最近 研究表明，这可能会导致这些错误。但是，迄今为止尚无研究直接相关的目光 并在这个人群中阅读。凝视涉及头和眼睛的协调，以向目标方向。 但是，到目前为止，大多数与SN和ND的目光相关的研究都要求头部稳定在中线。 因此，头部和眼睛对SN和ND中注视不对称的相对贡献尚不清楚。 当前SN和ND的神经解剖模型表明，它是由与A相互作用的中断引起的 双边背注意网络，它可以巩固空间注意力和眼动，并且单侧右边 半球腹侧注意网络，支持唤醒，警惕，对新刺激的检测和 重新定位对新型刺激的关注。尚不清楚网络破坏如何导致特定类型的ND。在 这个项目，我们将研究视线在ND阅读错误上的预测价值，这是该项目的相对贡献 凝视方向的头和眼睛，以及特定凝视模式和的神经网络中断 以中心为中心的和中心的误差模式。 （1）为了表征目光与阅读之间的关联，我们 将进行两个实验，以在单词阅读期间用可穿戴的眼动量测量凝视。我们 期望在参与者中找到凝视准确性和阅读准确性之间的牢固相关关系 ND，这将支持使用注视指标进行ND诊断和分类的潜力。 （2）至 确定头和眼睛对凝视缺陷的相对贡献，我们将使用 启用眼科运动的沉浸式虚拟现实，以在操纵头部旋转效果的同时测量目光。 我们希望参与者对头部的贡献更大 单词和更多的全词遗漏。 （3）确定凝视不对称和不对称和的神经网络 读取错误，我们将在有或没有ND的参与者的脑部扫描脑扫描，然后使用Voxel的病变 - 症状映射以将病变的大脑区域的程度相关联，以凝视准确性和阅读准确性。我们 预计会破坏背面网络的病变会损害中心凝视的方向，并与整个 单词遗漏，并且病变破坏了腹网络损害中心目光的方向和同事 与单方面的律师。