Gaze, Head Rotation, and Neuroanatomic Correlates of Reading Errors in Neglect Dyslexia

忽视阅读障碍中阅读错误的凝视、头部旋转和神经解剖学相关性

• 批准号: 10658715
• 负责人: Timothy John Rich
• 金额: $ 12.54万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658715
• 关键词: Activities of Daily Living; Affect; American; Applied Research; Area; Arousal; Attention; Basic Science; Behavior; Behavioral; Bilateral; Biometry; Brain; Brain Mapping; Brain scan; Classification; Clinical assessments; Cognition; Data; Detection; Diagnosis; Dorsal; Dyslexia; Etiology; Eye; Eye Movements; Face; Functional disorder; Funding; Goals; Head; Impairment; Individual; Intervention; Left; Leisures; Lesion; Letters; Literature; Location; Maps; Measures; Mentored Research Scientist Development Award; Modeling; National Institute of Child Health and Human Development; Neuroanatomy; Neurologic; Neuropsychology; Neurosciences Research; Outcome; Participant; Patients; Pattern; Play; Population; Positioning Attribute; Predictive Value; Reader; Reading; Reading Disorder; Rehabilitation therapy; Research; Role; Rotation; Side; Stimulus; Stroke; Symptoms; Technology; Training; United States National Institutes of Health; Visuospatial; Work; behavior test; cognitive neuroscience; experience; experimental study; functional gain; functional independence; gaze; improved; innovation; interest; neglect; nerve injury; neural network; neuroimaging; neurological rehabilitation; novel; post stroke; rehabilitation science; spatial neglect; stroke survivor; support network; treatment response; vigilance; virtual reality environment; visual stimulus; visual tracking

PROJECT SUMMARY/ABSTRACT Neglect dyslexia (ND) is an acquired reading disorder associated with spatial neglect (SN), commonly experienced by right hemisphere stroke survivors. ND causes whole-word omissions of left-sided words and errors on the left-sided letters of individual words (unilateral paralexias). These two distinct error types can be explained by dysfunctional egocentric (i.e., viewer-centered) and allocentric (i.e., object-centered) spatial cognition, respectively. Gaze asymmetry has long been considered a hallmark symptom of SN, and recent research suggests that it might contribute to these errors. However, no study to date has directly correlated gaze and reading in this population. Gaze involves the coordination of the head and eyes to orient toward a target. However, most gaze-related research in SN and ND thus far has required the head to be stabilized at midline. Therefore, relative contributions of the head and eyes to the asymmetry of gaze in SN and ND is unknown. Current neuroanatomical models of SN and ND suggest that it is caused by disruptions to the interaction of a bilateral dorsal attention network, which subserves spatial attention and eye movements, and a unilateral right hemisphere ventral attention network, which supports arousal, vigilance, detection of novel stimuli, and reorienting attention to novel stimuli. It is unknown how a network disruption leads to a specific type of ND. In this project, we will examine the predictive value of gaze on ND reading errors, the relative contributions of the head and eyes to gaze orientation, and the disrupted neural networks that underlie specific gaze patterns and egocentric and allocentric ND error patterns. (1) To characterize the association between gaze and reading, we will conduct two experiments that measure gaze with a wearable eye tracker during single-word reading. We expect to find a strong correlative relationship between gaze accuracy and reading accuracy in participants with ND, which would support the potential for the use of gaze metrics for ND diagnosis and classification. (2) To determine the relative contributions of the head and eyes to gaze deficits, we will conduct an experiment using eye tracking-enabled immersive virtual reality to measure gaze while manipulating the effect of head rotation. We expect participants with a greater contribution of the head to have poorer egocentric gaze toward left-sided words and more whole-word omissions. (3) To identify the neural networks that underlie gaze asymmetry and reading errors, we will lesion map brain scans of participants with and without ND, then use voxel-wise lesion- symptom mapping to correlate the degree of lesioned brain areas to gaze accuracy and reading accuracy. We anticipate that lesions disrupting the dorsal network impair egocentric gaze orientation and associate with whole- word omissions, and that lesions disrupting the ventral network impair allocentric gaze orientation and associate with unilateral paralexias.

项目总结/摘要 神经性阅读障碍（ND）是一种与空间忽略（SN）相关的获得性阅读障碍，通常 右半球中风幸存者的经历。ND导致左侧词的全词遗漏， 个别单词的左侧字母错误（单侧不对称）。这两种不同的错误类型可以是 用功能失调的自我中心来解释（即，以观看者为中心）和非中心（即，以对象为中心）空间 认知，分别。凝视不对称长期以来被认为是SN的标志性症状，并且最近 研究表明，它可能有助于这些错误。然而，到目前为止，还没有研究直接与凝视相关， 和阅读的能力。凝视涉及头部和眼睛的协调以朝向目标。 然而，迄今为止，SN和ND中的大多数凝视相关研究都要求头部稳定在中线。 因此，头部和眼睛对SN和ND中凝视不对称的相对贡献是未知的。 目前SN和ND的神经解剖学模型表明，它是由一个神经元之间的相互作用中断引起的。 双侧背侧注意力网络，促进空间注意力和眼球运动，以及单侧右侧 半球腹侧注意网络，支持唤醒、警惕、检测新刺激，以及 将注意力重新导向新的刺激。目前尚不清楚网络中断如何导致特定类型的ND。在 在这个项目中，我们将研究注视对ND阅读错误的预测价值， 头部和眼睛的凝视方向，以及破坏神经网络的基础特定的凝视模式， 自我中心和非自我中心的ND错误模式。(1)为了描述凝视和阅读之间的联系，我们 将进行两个实验，在单个单词的阅读过程中，用可佩戴的眼动仪测量凝视。我们 我希望在参与者中发现凝视准确性和阅读准确性之间的强相关关系， ND，这将支持用于ND诊断和分类的凝视度量的使用的潜力。(2)到 为了确定头部和眼睛对凝视缺陷的相对贡献，我们将进行一项实验， 眼动跟踪使能的沉浸式虚拟现实，以测量注视，同时操纵头部旋转的效果。 我们预计，头部贡献较大的参与者对左侧的自我中心注视较差 单词和更多的全词省略。(3)为了识别构成凝视不对称的神经网络， 阅读错误，我们将病变地图的参与者与非ND的大脑扫描，然后使用体素明智的病变- 症状映射以将受损脑区的程度与凝视准确性和阅读准确性相关联。我们 预期破坏背侧网络的病变会损害自我中心的注视方向，并与整体- 词遗漏，以及破坏腹侧网络的病变损害了非中心性注视方向和相关的 单侧性精神分裂症