Exposure to Per- and Polyfluoroalkyl Substances and Child Lung Function

项目总结/摘要 全氟烷基和多氟烷基物质（PFAS）是一组持久性和生物累积性化学品，用于 大量的工业和消费产品，已在血液中超过97%的测量 在全国代表性研究中，6岁以上的人群。PFAS通常被评估为个体 化学物质，但存在于已知和未知化合物的多样性和复杂的化学混合物中， 环境和人体。由于胎儿期肺部快速发育和生长 和儿童期，这些发育期可能特别容易受到PFAS的不利影响， 肺功能儿童期肺功能受损与成年期肺功能受损相关， 反过来又与慢性病的早发和各种原因造成的过早死亡有关。动物研究 表明PFAS对肺成熟、表面活性物质功能和肺泡完整性产生不利影响，但影响有限 流行病学研究探索PFAS与儿童肺功能之间的关系。的结果 以往的流行病学研究有限，不确定，缺乏纵向评估。我们的研究 建议在Viva项目中研究PFAS和PFAS混合物对儿童肺功能的影响， 1999年至2002年期间，在马萨诸塞州招募了1116对母婴进行出生前队列研究。 具体来说，我们将1）评估产前暴露于PFAS和PFAS混合物之间的关联， 儿童中期的肺功能，以及2）评估儿童中期PFAS和PFAS混合物之间的关联 和肺功能的影响。据我们所知，这将是第一项评估 PFAS混合物对儿童肺功能的影响，以及这些化学品对肺的纵向影响 健康当我们试图确定PFAS对肺功能影响的潜在因果途径时， 发展时期，我们的研究结果可能支持PFAS缓解和调节，以及发展 有针对性的干预措施，以减少以后生活中肺部疾病的风险。

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are a group of persistent and bioaccumulative chemicals used in a large number of industrial and consumer products that have been measured in blood of more than 97% of the population above 6 years in nationally representative studies. PFAS are commonly assessed as individual chemicals, but exist as diverse and complex chemical mixtures of known and unknown compounds in the environment and human body. Due to rapid lung development and growth that occurs during the prenatal period and childhood, these developmental periods may be particularly susceptible to the adverse effects of PFAS on lung function. Impaired lung function in childhood is associated with impaired lung function in adulthood, which in turn is associated with early onset of chronic diseases and premature mortality from all causes. Animal studies suggest PFAS adversely affect lung maturation, surfactant function, and alveolar integrity, but there are limited epidemiological studies exploring the association between PFAS and lung function in children. The findings from the previous epidemiological studies are limited, inconclusive, and lack longitudinal assessment. Our study proposes to investigate the effects of PFAS and PFAS mixtures on children’s lung function in Project Viva, an ongoing pre-birth cohort study of 1116 mother-child pairs recruited in Massachusetts between 1999 and 2002. Specifically, we will 1) evaluate the association between prenatal exposure to PFAS and PFAS mixtures and lung function in mid-childhood, and 2) assess the association between mid-childhood PFAS and PFAS mixtures and lung function in mid-childhood and adolescence. To our knowledge, this will be the first study to assess the effects of PFAS mixtures on lung function in children, and the longitudinal effects of these chemicals on lung health. As we seek to identify potential causal pathways for the impact of PFAS on lung function during developmental periods, our findings may support PFAS mitigation and regulation, and the development of targeted interventions to reduce the risk of lung illness later in life.