Exposure to Per- and Polyfluoroalkyl Substances and Child Lung Function

项目摘要/摘要 全氟和多氟烷基物质(PFAS)是一组持久性和生物累积性化学品，用于 大量的工业和消费品已经在血液中测量了97%以上 全国代表性研究中6岁以上的人口。PFA通常按个人进行评估 化学物质，但作为已知和未知化合物的多样化和复杂的化学混合物存在于 环境与人体。由于发生在产前的快速的肺部发育和生长 在儿童时期，这些发育期可能特别容易受到全氟辛烷磺酸的不利影响 肺功能。儿童肺功能受损与成年肺功能受损有关， 反过来，它又与慢性病的早期发病和各种原因导致的过早死亡有关。动物研究 提示PFAS对肺成熟、表面活性物质功能和肺泡完整性有不利影响，但有局限性 流行病学研究探索PFAS与儿童肺功能的关系。调查结果来自 以往的流行病学研究是有限的、不确定的，并且缺乏纵向评估。我们的研究 建议在Viva项目中调查PFAS和PFAS混合物对儿童肺功能的影响 对1999年至2002年间在马萨诸塞州招募的1116对母子进行了产前队列研究。 具体地说，我们将1)评估产前接触全氟辛烷磺酸和全氟辛烷磺酸混合物之间的联系，以及 儿童中期的肺功能，以及2)评估儿童中期PFAS和PFAS混合物之间的关联 以及儿童中期和青春期的肺功能。据我们所知，这将是第一次评估 全氟辛烷磺酸混合物对儿童肺功能的影响及其对肺的纵向影响 健康。当我们试图确定PFAS对肺功能影响的潜在因果途径时 发展阶段，我们的研究结果可能支持全氟辛烷磺酸的缓解和监管，以及发展 有针对性的干预措施，以降低晚年患肺部疾病的风险。

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are a group of persistent and bioaccumulative chemicals used in a large number of industrial and consumer products that have been measured in blood of more than 97% of the population above 6 years in nationally representative studies. PFAS are commonly assessed as individual chemicals, but exist as diverse and complex chemical mixtures of known and unknown compounds in the environment and human body. Due to rapid lung development and growth that occurs during the prenatal period and childhood, these developmental periods may be particularly susceptible to the adverse effects of PFAS on lung function. Impaired lung function in childhood is associated with impaired lung function in adulthood, which in turn is associated with early onset of chronic diseases and premature mortality from all causes. Animal studies suggest PFAS adversely affect lung maturation, surfactant function, and alveolar integrity, but there are limited epidemiological studies exploring the association between PFAS and lung function in children. The findings from the previous epidemiological studies are limited, inconclusive, and lack longitudinal assessment. Our study proposes to investigate the effects of PFAS and PFAS mixtures on children’s lung function in Project Viva, an ongoing pre-birth cohort study of 1116 mother-child pairs recruited in Massachusetts between 1999 and 2002. Specifically, we will 1) evaluate the association between prenatal exposure to PFAS and PFAS mixtures and lung function in mid-childhood, and 2) assess the association between mid-childhood PFAS and PFAS mixtures and lung function in mid-childhood and adolescence. To our knowledge, this will be the first study to assess the effects of PFAS mixtures on lung function in children, and the longitudinal effects of these chemicals on lung health. As we seek to identify potential causal pathways for the impact of PFAS on lung function during developmental periods, our findings may support PFAS mitigation and regulation, and the development of targeted interventions to reduce the risk of lung illness later in life.