Exposure to Per- and Polyfluoroalkyl Substances and Child Lung Function

接触全氟烷基和多氟烷基物质与儿童肺功能

• 批准号: 10658859
• 负责人: Jennifer Ann-Marie Oliver
• 金额: $ 2.91万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10658859
• 关键词: 6 year old; Address; Adolescence; Adolescent; Adult; Adverse effects; Affect; Airway Resistance; Alveolar; Animals; Asthma; Biometry; Birth; Blood; Chemical Exposure; Chemicals; Child; Childhood; Chronic Disease; Chronic Obstructive Pulmonary Disease; Cohort Studies; Complex; Data; Development; Early Intervention; Environment; Environmental Exposure; Epidemiology; Exposure to; First Pregnancy Trimester; Forced expiratory volume function; Funding; Future; Goals; Growth; Growth and Development function; Health; Human body; Impairment; Individual; Industrial Product; Intervention; Life; Life Cycle Stages; Literature; Longevity; Low Birth Weight Infant; Lung; Massachusetts; Measurement; Measures; Medicine; Mentorship; Mothers; National Institute of Environmental Health Sciences; Organic Chemicals; Outcome; Pathway interactions; Pediatric epidemiology; Perinatal Epidemiology; Plasma; Poly-fluoroalkyl substances; Population; Predisposition; Pregnancy; Pregnant Women; Premature Mortality; Prevention strategy; Public Health; Pulmonology; Quality of life; Regulation; Research; Risk Reduction; Statistical Methods; Time; Toxic effect; Training; Training and Education; United States National Institutes of Health; Vaccines; Vital capacity; Wheezing; asthmatic; career; cohort; consumer product; critical period; early adolescence; early childhood; early life exposure; early onset; environmental chemical; epidemiology study; health communication; improved; in utero; lung development; lung health; lung maturation; lung volume; prenatal; prenatal exposure; pulmonary function; recruit; respiratory; respiratory health; response; surfactant function

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are a group of persistent and bioaccumulative chemicals used in a large number of industrial and consumer products that have been measured in blood of more than 97% of the population above 6 years in nationally representative studies. PFAS are commonly assessed as individual chemicals, but exist as diverse and complex chemical mixtures of known and unknown compounds in the environment and human body. Due to rapid lung development and growth that occurs during the prenatal period and childhood, these developmental periods may be particularly susceptible to the adverse effects of PFAS on lung function. Impaired lung function in childhood is associated with impaired lung function in adulthood, which in turn is associated with early onset of chronic diseases and premature mortality from all causes. Animal studies suggest PFAS adversely affect lung maturation, surfactant function, and alveolar integrity, but there are limited epidemiological studies exploring the association between PFAS and lung function in children. The findings from the previous epidemiological studies are limited, inconclusive, and lack longitudinal assessment. Our study proposes to investigate the effects of PFAS and PFAS mixtures on children’s lung function in Project Viva, an ongoing pre-birth cohort study of 1116 mother-child pairs recruited in Massachusetts between 1999 and 2002. Specifically, we will 1) evaluate the association between prenatal exposure to PFAS and PFAS mixtures and lung function in mid-childhood, and 2) assess the association between mid-childhood PFAS and PFAS mixtures and lung function in mid-childhood and adolescence. To our knowledge, this will be the first study to assess the effects of PFAS mixtures on lung function in children, and the longitudinal effects of these chemicals on lung health. As we seek to identify potential causal pathways for the impact of PFAS on lung function during developmental periods, our findings may support PFAS mitigation and regulation, and the development of targeted interventions to reduce the risk of lung illness later in life.

项目概要/摘要 全氟烷基物质和多氟烷基物质 (PFAS) 是一组持久性和生物累积性化学品，用于 大量工业和消费品已在97%以上的血液中进行了测量 全国代表性研究中 6 岁以上人口。 PFAS 通常被单独评估 化学物质，但以已知和未知化合物的多样化和复杂的化学混合物形式存在 环境和人体。由于产前期间肺部快速发育和生长 和儿童时期，这些发育时期可能特别容易受到 PFAS 对身体的不利影响。 肺功能。儿童期肺功能受损与成年期肺功能受损有关， 反过来又与各种原因造成的慢性病过早发病和过早死亡有关。动物研究 表明 PFAS 对肺成熟、表面活性剂功能和肺泡完整性产生不利影响，但影响有限 流行病学研究探索 PFAS 与儿童肺功能之间的关系。研究结果来自 以往的流行病学研究有限、缺乏结论、缺乏纵向评估。我们的研究 提议在 Viva 项目中研究 PFAS 和 PFAS 混合物对儿童肺功能的影响，该项目是一项 1999 年至 2002 年间在马萨诸塞州招募的 1116 对母子对正在进行的产前队列研究。 具体来说，我们将 1) 评估产前接触 PFAS 和 PFAS 混合物之间的关联 儿童中期的肺功能，2) 评估儿童中期 PFAS 和 PFAS 混合物之间的关联 以及儿童中期和青春期的肺功能。据我们所知，这将是第一项评估 PFAS 混合物对儿童肺功能的影响，以及这些化学物质对肺的纵向影响 健康。当我们寻求确定 PFAS 对肺功能影响的潜在因果途径时， 发展阶段，我们的研究结果可能支持 PFAS 的缓解和监管，以及 有针对性的干预措施，以降低晚年患肺部疾病的风险。