Health and Metabolism Research Core

健康与新陈代谢研究核心

• 批准号: 10659064
• 负责人: Cory Williams
• 金额: $ 23.76万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-16 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659064
• 关键词: 3-Dimensional; Adipose tissue; Agreement; Alaska; Alaskan; Animal Model; Animals; Applied Research; Arctic Regions; Basic Science; Biological; Blood Glucose; Blood Pressure; Body Composition; Body Temperature; Bone Density; Bone Mineral Contents; Businesses; Centers of Research Excellence; Chemicals; Clinical; Clinical Research; Clinical Sciences; Collaborations; Collection; Communities; Computer software; Consultations; Custom; Data; Data Analyses; Data Science; Dedications; Development; Diagnostic Imaging; Discipline; Doctor of Philosophy; Dual-Energy X-Ray Absorptiometry; Electrocardiogram; Elements; Ensure; Equipment; Essential Amino Acids; Fatty acid glycerol esters; Fees; Foundations; Goals; Health; Hibernation; Homeostasis; Hospitals; Human; Human Resources; Human Subject Research; Idaho; Image; Implant; In Vitro; Infrastructure; International; Intervention; Isometric Exercise; Kinetics; Laboratories; Lipids; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mammals; Martes zibellina; Mercury; Metabolic; Metabolic Diseases; Metabolism; Methodology; Monitor; Montana; NMR Spectroscopy; Oxygen Consumption; Participant; Peripheral; Phase; Physiological; Play; Population Heterogeneity; Protons; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Roentgen Rays; Scientist; Services; Shapes; Site; Spirometry; System; Techniques; Telemetry; Testing; Thinness; Time; Tissues; Translating; Translational Research; Universities; Urea Nitrogen; Washington; Wyoming; base; chemical reaction; clinical care; computerized data processing; data acquisition; density; design; effective intervention; experimental study; flexibility; health goals; human model; human subject; imaging facilities; in vivo; in vivo imaging; instrument; instrumentation; interdisciplinary collaboration; intrahepatic; lean body mass; metabolomics; microbial; molecular imaging; operation; patient oriented research; programs; research facility; research study; respiratory; small molecule; spectroscopic imaging; tool

Project Summary – Health and Metabolism Research (HaMR) Core In vivo imaging and animal instrumentation are key elements of the proposed COBRE Center for Transformative Research in Metabolism. The Health and Metabolism Research (HaMR) Core combines an existing Molecular Imaging Facility with existing equipment and expertise in animal instrumentation. The goal of the Core is to co-locate basic research in hibernation with human subject's research to promote interdisciplinary collaboration and transformative discoveries and to adapt to the needs of the proposed COBRE Center. We will accomplish this goal by accomplishing the following Specific Aims (SA). SA1. Support the Molecular Imaging Facility (MIF) to provide technical assistance, expert consultation, and sophisticated, state-of-the-art instrumentation for in-vivo and in-vitro basic and translational research. SA2. To support project PIs and other COBRE investigators in the collection & processing of metabolic and physiological data using animal instrumentation. SA3. To implement and continually refine our business plan for long-term sustainable operation of the Core. The HaMR Core houses the only research dedicated magnetic resonance facility in the UA system and in the state of Alaska, enhancing capacity for basic research using unique Arctic animal models and for translational and clinical research in Alaskan human subjects. The HaMR Core is an essential component of the Research Projects supported by the Phase 1 COBRE, providing technical assistance, expert consultation, and instrumentation for basic and clinical research. The Core includes a Molecular Imaging Facility, established in 2014, that houses a Toshiba 1.5 Tesla MRI, two NMRs (300 and 600MHz), and a Dual-energy X-ray Absorptiometry (DXA) instrument. This facility is an important regional resource, identified as a clinical research center site within the Northwest Participant and Clinical Interactions Network (NW PCI). HaMR Core services include technical support and expertise in methodologies for monitoring metabolism, via open-flow respirometry and biotelemtry, in hibernating species and laboratory rodents.

健康与代谢研究（HaMR）核心 体内成像和动物仪器是拟议的COBRE中心的关键要素， 代谢的变革性研究。健康和代谢研究（HaMR）核心结合了 现有的分子成像设施，现有的设备和动物仪器的专业知识。目标 核心是将冬眠中的基础研究与人类受试者的研究放在一起， 跨学科合作和变革性的发现，并适应所提出的 眼镜蛇中心我们将通过实现以下具体目标（SA）来实现这一目标。SA 1.支持 分子成像设施（MIF）提供技术援助，专家咨询， 用于体内和体外基础和转化研究的先进仪器。SA 2.到 支持项目PI和其他COBRE调查人员收集和处理代谢产物， 和生理数据。SA 3.实施并不断完善我们的业务 为核心的长期可持续运营制定计划。HaMR核心包含了唯一一个 在UA系统和阿拉斯加州建立磁共振设施，提高基础研究能力 使用独特的北极动物模型和阿拉斯加人类受试者的转化和临床研究。的 HaMR核心是COBRE第一阶段支持的研究项目的重要组成部分， 技术援助、专家咨询以及基础和临床研究仪器。核心 包括2014年建立的分子成像设施，该设施拥有东芝1.5特斯拉MRI，两个NMR (300和600MHz）和双能X射线吸收测定（DXA）仪器。该设施是一个重要的 区域资源，确定为西北参与者和临床研究中心内的临床研究中心 交互网络（NW PCI）。HaMR核心服务包括技术支持和方法学方面的专业知识 通过开放流呼吸测定法和生物遥测法监测冬眠物种和实验室的代谢 啮齿动物