Health and Metabolism Research Core

项目摘要-健康和新陈代谢研究(HAMR)核心 活体成像和动物仪器是拟议的科布雷中心的关键要素 新陈代谢的变革性研究。健康和新陈代谢研究(HAMR)核心结合了 现有的分子成像设备和现有的动物仪器设备和专业知识。目标是 核心是把冬眠中的基础研究与人类主体的研究放在一起，促进 跨学科协作和变革性发现，并适应提议的 科布雷中心。我们将通过实现以下具体目标(SA)来实现这一目标。SA1.支持 分子成像设备(MIF)，提供技术援助、专家咨询和 用于体内和体外基础和翻译研究的精密、最先进的仪器。SA2.至 支持项目PI和其他Cobre调查人员收集和处理代谢 以及使用动物仪器的生理数据。SA3.执行并持续改进我们的业务 为核心的长期可持续运作制定计划。HAMR核心拥有唯一致力于研究的 UA系统和阿拉斯加州的磁共振设施，增强基础研究能力 使用独特的北极动物模型，并在阿拉斯加人类受试者中进行翻译和临床研究。这个 HAMR核心是第一阶段科布雷支持的研究项目的重要组成部分，提供 基础和临床研究的技术援助、专家咨询和仪器设备。《核心》 包括一家分子成像设施，成立于2014年，其中包括一台东芝1.5特斯拉MRI、两台NMR (300和600 MHz)和一台双能X射线吸收测量仪(DXA)。这个设施是一个重要的 地区性资源，在西北参与者和临床中心内确定为临床研究中心站点 交互网络(NW PCI)。HAMR核心服务包括技术支持和方法学专业知识 用于监测冬眠物种和实验室的新陈代谢，通过开放式呼吸测量和生物遥测 啮齿动物。

Project Summary – Health and Metabolism Research (HaMR) Core In vivo imaging and animal instrumentation are key elements of the proposed COBRE Center for Transformative Research in Metabolism. The Health and Metabolism Research (HaMR) Core combines an existing Molecular Imaging Facility with existing equipment and expertise in animal instrumentation. The goal of the Core is to co-locate basic research in hibernation with human subject's research to promote interdisciplinary collaboration and transformative discoveries and to adapt to the needs of the proposed COBRE Center. We will accomplish this goal by accomplishing the following Specific Aims (SA). SA1. Support the Molecular Imaging Facility (MIF) to provide technical assistance, expert consultation, and sophisticated, state-of-the-art instrumentation for in-vivo and in-vitro basic and translational research. SA2. To support project PIs and other COBRE investigators in the collection & processing of metabolic and physiological data using animal instrumentation. SA3. To implement and continually refine our business plan for long-term sustainable operation of the Core. The HaMR Core houses the only research dedicated magnetic resonance facility in the UA system and in the state of Alaska, enhancing capacity for basic research using unique Arctic animal models and for translational and clinical research in Alaskan human subjects. The HaMR Core is an essential component of the Research Projects supported by the Phase 1 COBRE, providing technical assistance, expert consultation, and instrumentation for basic and clinical research. The Core includes a Molecular Imaging Facility, established in 2014, that houses a Toshiba 1.5 Tesla MRI, two NMRs (300 and 600MHz), and a Dual-energy X-ray Absorptiometry (DXA) instrument. This facility is an important regional resource, identified as a clinical research center site within the Northwest Participant and Clinical Interactions Network (NW PCI). HaMR Core services include technical support and expertise in methodologies for monitoring metabolism, via open-flow respirometry and biotelemtry, in hibernating species and laboratory rodents.