The St. Jude Lifetime Cohort

圣裘德终身队列

• 批准号: 10658864
• 负责人: MELISSA M HUDSON
• 金额: $ 110.92万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-09 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658864
• 关键词: Acceleration; Address; Adolescent; Adult; Age; Aging; Architecture; Auditory system; Award; Biological Markers; Biological Specimen Banks; Blood; Cancer Patient; Cancer Survivorship; Cardiovascular system; Childhood; Childhood Cancer Treatment; Clinical; Clinical Data; Clinical assessments; Cloud Computing; Collaborations; Communities; Complex; Data; Data Analytics; Data Set; Data Sources; Databases; Development; Diagnosis; Eligibility Determination; Endocrine system; Enrollment; Environment; Evaluation; Functional disorder; Funding; Future; Genetic; Genomics; Grant; Health behavior; Individual; Informed Consent; Infrastructure; Institution; Intervention; Intuition; Investigation; Late Effects; Long-Term Effects; Long-Term Survivors; Longevity; Malignant Childhood Neoplasm; Malignant Neoplasms; Manuscripts; Measures; Medial; Medical; Monitor; Morbidity - disease rate; Neoplasms; Neurocognitive Deficit; Outcome; Participant; Patient Self-Report; Patients; Pediatric cohort; Peer Review; Performance; Phenotype; Physiological; Population; Preventive; Productivity; Public Health; Publishing; Reproductive system; Research; Research Personnel; Resources; Respiratory System; Risk; Risk Estimate; Role; Saint Jude Children' s Research Hospital; Sampling; Secure; Services; Source; Survivors; Testing; Time; Treatment Protocols; Treatment-Related Cancer; Treatment-related toxicity; Urine; Validation; Vial device; Visit; Visualization; Visualization software; adverse outcome; biobank; cancer diagnosis; childhood cancer survivor; clinical application; clinical predictive model; cloud based; cohort; comorbidity; data infrastructure; data registry; data sharing; demographics; design; exome; exome sequencing; experience; field study; flexibility; follow-up; genome sequencing; genomic data; handheld mobile device; health assessment; health related quality of life; high risk; high risk population; human old age (65+); innovation; insight; interest; interoperability; mHealth; next generation sequence data; next generation sequencing; participant enrollment; predictive modeling; predictive tools; prospective; repository; research clinical testing; risk prediction; risk prediction model; sensor; shared database; sharing platform; sociodemographics; success; survivorship; therapy adverse effect; whole genome

Abstract Because many adverse effects of treatment for childhood cancer may not become clinically apparent until the survivor attains maturity or older ages, continued follow-up across the lifespan, from childhood through adulthood, is essential. With the number of childhood cancer survivors in the U.S approaching 500,000, there is a critical need to accurately characterize the development and manifestation of very late cancer-related sequelae. In late 2007, St. Jude Children’s Research Hospital initiated a unique clinical (i.e., medically evaluated) cohort with the primary aim of undertaking lifelong evaluation of health-related and quality of life outcomes in aging adult survivors of pediatric cancer. Eligibility for participation in the St. Jude Lifetime Cohort (SJLIFE) was initially defined as survival >10 years from diagnosis, and attained age of >18 years. With the award of the U01 Cohort Infrastructure grant (U01 CA195547) in July 2015, eligibility for the cohort was modified to include >5 year survivors. Participation rates for the cohort remain high with 80.4% of the 7152 contacted survivors having been successfully enrolled and an additional 6.8% with expressed interest in participating but pending an on-campus visit to provide informed consent. As of February 1, 2019, total enrollment on SJLIFE is 5753 survivors and 629 controls. Accomplishments over the 43 months since award of the U01 include: 2657 new participants enrolled, implementation of uniform medical assessments with 4096 on-campus clinical evaluations (reflecting performance of 263,165 clinical tests), banking of biospecimens for 94% of new participants (43,240 vials), germline whole genome sequencing of 4422 survivors, 22 active investigator-initiated funded grants utilizing the cohort, 22 active intervention-based trials, 27 data sharing collaborations, and 78 manuscripts submitted with 69 published/in press. In this competitive renewal application we propose to build upon these successes through activities to maintain and enhance the SJLIFE cohort as a unique and highly productive resource for pediatric cancer survivorship research and to directly: (1) facilitate an accelerated rate of discovery in survivorship research by establishing an innovative cloud-based data sharing platform to make clinical and genomic data from the SJLIFE cohort available to the global research community; (2) facilitate the investigation of genetic contributions to and pathophysiology of treatment-associated adverse long-term outcomes among survivors of childhood cancer; and, (3) facilitate establishment of a portfolio of validated risk prediction tools for clinical use in the management of pediatric cancer patients from the time of diagnosis through survivorship. The SJLIFE cohort will continue to be unique in its ability to provide new insights into the risks and pathophysiology of morbidity associated with cancer and its therapy, which is critical to the design of contemporary treatment protocols and public health initiatives to enable survivor access to preventive and remedial services.

摘要

项目成果

Factors for poor oral health in long-term childhood cancer survivors.

长期儿童癌症幸存者口腔健康状况不佳的因素。

• DOI: 10.1186/s12903-023-02762-0
• 发表时间: 2023-02-04
• 期刊: BMC ORAL HEALTH
• 影响因子: 2.9
• 作者: Patni, Tushar;Lee, Chun-Teh;Li, Yimei;Kaste, Sue;Zhu, Liang;Sun, Ryan;Hudson, Melissa M.;Ness, Kirsten K.;Neumann, Ana;Robison, Leslie L.
• 通讯作者: Robison, Leslie L.

Child symptoms, parent behaviors, and family strain in long-term survivors of childhood acute lymphoblastic leukemia.

• DOI: 10.1002/pon.4769
• 发表时间: 2018-08
• 期刊: Psycho-oncology
• 影响因子: 3.6
• 作者: Huang IC;Brinkman TM;Mullins L;Pui CH;Robison LL;Hudson MM;Krull KR
• 通讯作者: Krull KR

The impact of childhood cancer: Perceptions of adult survivors.

儿童癌症的影响：成年幸存者的看法。

• DOI: 10.1002/cncr.30514
• 发表时间: 2017
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Willard,VictoriaW;Klosky,JamesL;Li,Chenghong;Srivastava,DeoKumar;Brinkman,TaraM;Robison,LeslieL;Hudson,MelissaM;Phipps,Sean
• 通讯作者: Phipps,Sean

Dietary supplement use among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study.

儿童癌症成年幸存者中膳食补充剂的使用：来自圣裘德终身队列研究的报告。

• DOI: 10.1002/cncr.34700
• 发表时间: 2023
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Zhang,FangFang;Hudson,MelissaM;Chen,Fan;Li,Zhongyu;Huang,I-Chan;Bhakta,Nickhill;Ness,KirstenK;Brinkman,TaraM;Klosky,James;Ojha,RohitP;Lanctot,JenniferQ;Robison,LeslieL;Krull,KevinR
• 通讯作者: Krull,KevinR

T-type Corrected-Loss Estimation for Error-in-Variable Model.

变量误差模型的 t 型校正损失估计

• DOI: 10.1080/03610926.2014.1002934
• 发表时间: 2017
• 期刊: Communications in statistics: theory and methods
• 作者: Jin J;Zhu L;Tong X;Ness KK
• 通讯作者: Ness KK