HEALthy Brain and Child Development Study at UAB and UA

早期的大脑发育经历了快速变化和脆弱时期，各种不同的 环境暴露会对早期神经发育和长期的 健康结果。体验将通过表观遗传变化永久性地改变大脑结构和功能 除了大脑可塑性和大脑可塑性之间的相互作用外，这还有助于个体差异 自主神经内分泌、代谢和免疫功能。很少有研究涉及早期大脑 发展和轨迹受早期经验和潜在的生物相互作用的影响 人口多样化，包括农村人口和少数族裔人口。Heave倡议的中心目标：健康 大脑和儿童发展研究是前瞻性地检查从出生起的大脑和行为发育 通过儿童时期，强调宫内物质暴露对结局的影响。 在阿拉巴马大学伯明翰分校(UAB)和阿拉巴马大学(UA)，我们将招收孕妇 对怀孕中期的妇女进行全面的多模式纵向数据跟踪调查 学习。UAB的优势包括全面的孕期成瘾计划(CAPP)，该计划提供 对有药物使用史的孕妇进行产前护理和支持。UAB OB支持多种产前检查 杰斐逊和布朗特县卫生部内的诊所，社区卫生中心和 合并症门诊。UAB正在积极招募参与者参与阿片类药物婴儿的治疗结果 暴露和ACT Now断奶研究。UAB是NICHD孕产妇医学网络的一个网站， NICHD新生儿研究网络已有25年的历史，具有悠久、完善和高效的网络 与其他中心的合作。UA在塔斯卡卢萨的大学医疗中心运营，该中心为 该地区的大多数医疗补助接受者以及周围县的农村诊所，包括 在阿拉巴马州黑带。UA团队在神经成像、EEG、农村健康、孕产妇健康和 儿童发展。因此，临床、研究、管理和设施都已证明是足够的。 来完成这个项目。我们明确表示愿意与对方以合作的方式参与 研究站点、HDCC、HCAC、NIH项目科学家和NIH项目官员在所有方面 以与奖项条款一致的方式进行研究。 具体目标：1.确定典型的神经发育轨迹和大脑的典型变异性范围 在一个不同的人群中，从出生到童年的发育。2.确定早年生活中暴露于 阿片类药物、其他物质和其他不利的环境条件会影响这些轨迹。3. 确定遗传影响如何与环境因素相互作用来影响神经发育。 设计：300个母子二元体(100个有药物暴露史，200个没有药物暴露史)，完全纵向 大脑、行为和生物评估，与Hear Initiative内的其他研究站点联合进行。

Brain development during the early years goes through rapid change with vulnerable periods where a variety of environmental exposures can have a large and enduring impact in early neurodevelopment and long-term health outcomes. Experiences will permanently modify brain structure and function through epigenetic changes that contribute to individual differences, in addition to reciprocal interactions among brain plasticity and autonomic neuroendocrine, metabolic, and immune functions. Few studies have addressed how early brain development and trajectories are impacted by early experiences and potential biological interactions within a diverse population inclusive of rural and minority populations. The central goal of the HEAL Initiative: HEALthy Brain and Child Development study is to prospectively examine brain and behavioral development from birth through childhood with emphasis on the impact of in utero substance exposure on outcome. At the University of Alabama at Birmingham (UAB) and the University of Alabama (UA) we will enroll pregnant women during their second trimester and follow their infants with a comprehensive multimodal data longitudinal study. Strengths to UAB include the Comprehensive Addiction in Pregnancy Program (CAPP) that provides prenatal care and support to pregnant women with history of substance use. UAB OB supports several prenatal clinics within Jefferson and Blount County Departments of Health, neighborhood health centers, and the Complications clinic. UAB is actively enrolling participants for the HEAL Outcomes of Babies with Opioid exposure and the ACT NOW Weaning study. UAB is a site for the NICHD Maternal Fetal Medicine Network and the NICHD Neonatal Research Network for >25 years, with long-standing, well-established and highly productive collaborations with other centers. UA operates at the University Medical Center in Tuscaloosa that serves the majority of the Medicaid recipients in the region as well as rural clinics in surrounding counties, including those in the Alabama Black Belt. The UA team has expertise in neuroimaging, EEG, rural health, maternal health and child development. Therefore, there is demonstrated adequacy of clinical, research, administrative and facilities to accomplish this project. We clearly express our intent to participate in a cooperative manner with the other research sites, the HDCC, HCAC, the NIH Program Scientist and the NIH Program Official in all aspects of research in a manner consistent with the terms of the award. Specific Aims: 1. Determine typical neurodevelopmental trajectories and typical range of variability of brain development from birth through childhood in a diverse population. 2. Determine how early life exposure to opioids, other substances, and other adverse environmental circumstances affect these trajectories. 3. Determine how genetic influences interact with environmental factors to influence neurodevelopment. Design: 300 mother/child dyads (100 with and 200 without history of drug exposure) with complete longitudinal brain, behavioral and biological assessment in conjunction with other research sites within the HEAL Initiative.