HEALthy Brain and Child Development Study at UAB and UA

大脑发育在早期经历了快速的变化与脆弱时期， 环境暴露对早期神经发育和长期神经发育可能产生巨大而持久的影响。 健康成果。经验将通过表观遗传变化永久地改变大脑结构和功能 这有助于个体差异，除了大脑可塑性之间的相互作用， 自主神经内分泌、代谢和免疫功能。很少有研究涉及早期大脑 发展和轨迹受到早期经验和潜在的生物相互作用的影响， 包括农村和少数民族人口在内的多样化人口。HEAL倡议的核心目标：健康 脑与儿童发育研究是从出生开始前瞻性地检查大脑和行为发育 通过儿童期，强调宫内物质暴露对结果的影响。 在伯明翰的亚拉巴马大学（UAB）和亚拉巴马大学（UA），我们将招收怀孕 妇女在第二个三个月，并遵循他们的婴儿与一个全面的多模态数据纵向 study. UAB的优势包括怀孕综合成瘾计划（CAPP）， 对有吸毒史的孕妇提供产前护理和支助。UAB OB支持几个产前 杰斐逊和布朗特县卫生部内的诊所，社区卫生中心，以及 并发症门诊。UAB正在积极招募阿片类药物婴儿的HEAL结局参与者 ACT NOW Weaning研究。UAB是NICHD产妇胎儿医学网络的网站， NICHD新生儿研究网络超过25年，具有长期，完善和高生产力 与其他中心合作。UA在塔斯卡卢萨的大学医疗中心工作， 该地区的大多数医疗补助接受者以及周边县的农村诊所，包括那些 在亚拉巴马黑带。UA团队在神经成像、脑电图、农村健康、孕产妇健康和 儿童发展。因此，证明了临床、研究、管理和设施的充分性 来完成这个项目。我们明确表示，我们打算以合作的方式与其他国家一道参加， 研究中心，HDCC，HCAC，NIH项目科学家和NIH项目官员在各个方面， 以符合奖励条款的方式进行研究。 具体目标：1。确定典型的神经发育轨迹和大脑的典型变异范围 从出生到童年，在不同的人群中发展。2.确定生命早期暴露于 阿片类药物、其他物质和其他不利的环境条件影响这些轨迹。3. 确定遗传影响如何与环境因素相互作用以影响神经发育。 设计：300对母子（100例有药物暴露史，200例无药物暴露史）， 大脑，行为和生物评估与其他研究网站内的愈合倡议。

Brain development during the early years goes through rapid change with vulnerable periods where a variety of environmental exposures can have a large and enduring impact in early neurodevelopment and long-term health outcomes. Experiences will permanently modify brain structure and function through epigenetic changes that contribute to individual differences, in addition to reciprocal interactions among brain plasticity and autonomic neuroendocrine, metabolic, and immune functions. Few studies have addressed how early brain development and trajectories are impacted by early experiences and potential biological interactions within a diverse population inclusive of rural and minority populations. The central goal of the HEAL Initiative: HEALthy Brain and Child Development study is to prospectively examine brain and behavioral development from birth through childhood with emphasis on the impact of in utero substance exposure on outcome. At the University of Alabama at Birmingham (UAB) and the University of Alabama (UA) we will enroll pregnant women during their second trimester and follow their infants with a comprehensive multimodal data longitudinal study. Strengths to UAB include the Comprehensive Addiction in Pregnancy Program (CAPP) that provides prenatal care and support to pregnant women with history of substance use. UAB OB supports several prenatal clinics within Jefferson and Blount County Departments of Health, neighborhood health centers, and the Complications clinic. UAB is actively enrolling participants for the HEAL Outcomes of Babies with Opioid exposure and the ACT NOW Weaning study. UAB is a site for the NICHD Maternal Fetal Medicine Network and the NICHD Neonatal Research Network for >25 years, with long-standing, well-established and highly productive collaborations with other centers. UA operates at the University Medical Center in Tuscaloosa that serves the majority of the Medicaid recipients in the region as well as rural clinics in surrounding counties, including those in the Alabama Black Belt. The UA team has expertise in neuroimaging, EEG, rural health, maternal health and child development. Therefore, there is demonstrated adequacy of clinical, research, administrative and facilities to accomplish this project. We clearly express our intent to participate in a cooperative manner with the other research sites, the HDCC, HCAC, the NIH Program Scientist and the NIH Program Official in all aspects of research in a manner consistent with the terms of the award. Specific Aims: 1. Determine typical neurodevelopmental trajectories and typical range of variability of brain development from birth through childhood in a diverse population. 2. Determine how early life exposure to opioids, other substances, and other adverse environmental circumstances affect these trajectories. 3. Determine how genetic influences interact with environmental factors to influence neurodevelopment. Design: 300 mother/child dyads (100 with and 200 without history of drug exposure) with complete longitudinal brain, behavioral and biological assessment in conjunction with other research sites within the HEAL Initiative.