Discovery Science Collaborative for CKDu

项目总结/摘要 CKDu肾脏科学核心发现科学合作的总体目标是将最好的 调查方法和科学技术来解决CKDu问题。我们将与菲尔德密切合作， 流行病学研究中心、科学数据协调中心、NIDDK领导层、外部监督 委员会和HHEAR设计临床表型研究并进行发现科学实验。 然后，我们将整合这些数据，以阐明CKDu发生在不同人群中的病因和进展因素。 农业社区。肾脏科学核心是一个多机构合作组织， 核心组成部分：基因组学，病理学，转录组学，生物标志物，生理学和生物信息学。的 RSC的具体目标是：（1）描述患者的临床表型和自然史， CKDu流行地区的CKDu和未受影响的个体，比较CKDu地区的特征， 确定不同地点和地区之间的相似性和差异程度;（2）引入尖端技术 利用分子技术在研究中心之间和研究中心内比较CKDu的风险因素和病理生理学 了解疾病病因学的共同和独特方面;（3）确定 流行地区的阿基和CKDu;以及（4）为假设和 非基于假设的方法来理解病因，这将成为正在进行的CKDu研究的核心。 RSC的领导团队在CKDu方面拥有丰富的工作经验， 国际工作组，并在其他主要NIDDK财团的领导作用。这个小组汇集了 在肾脏学、基因组学、肾脏病理学、数字病理学机器学习算法、单 细胞转录组学、生物标志物开发、蛋白质组学、代谢组学、肾脏生理学、生物信息学和 数据集成我们还招募了几位在新型病原体发现、新型 成像技术和环境采样。这些研究将使人们更好地了解 CKDu的潜在病理生理学。

PROJECT SUMMARY / ABSTRACT The overall goal of the Discovery Science Collaborative for CKDu Renal Science Core is to bring the best investigative methods and scientific technology to the problem of CKDu. We will work closely with Field Epidemiology Sites, the Scientific Data Coordinating Center, NIDDK Leadership, the External Oversight Committee, and HHEAR to design clinical phenotyping studies and perform discovery science experiments. We will then integrate this data to elucidate the etiology and progression factors of CKDu occurring in diverse agricultural communities. The Renal Science Core is a multi-institutional collaborative organized around six Core components: Genomics, Pathology, Transcriptomics, Biomarkers, Physiology, and Bioinformatics. The specific aims of the RSC are to: (1) characterize the clinical phenotypes and natural history of patients with CKDu and unaffected individuals in CKDu-endemic regions, comparing features across CKDu sites and determining the degree of similarities and differences across sites and regions; (2) introduce cutting-edge molecular technologies to compare the risk factors and pathophysiology of CKDu across and within study sites to understand both shared and unique aspects of the etiology of disease; (3) define the relationship between AKI and CKDu in endemic regions; and (4) build a flexible, adaptable infrastructure for both hypothesis- and non-hypothesis-based approaches to understanding etiology that will form the core of ongoing CKDu studies. The leadership team of the RSC has extensive experience working on CKDu, a history of collaboration on international working groups, and leadership roles on other major NIDDK consortia. This group brings together expertise in nephrology, genomics, nephropathology, machine learning algorithms for digital pathology, single- cell transcriptomics, biomarker development, proteomics, metabolomics, renal physiology, bioinformatics, and data integration. We have also enlisted several advisors with expertise in novel pathogen discovery, novel imaging technologies, and environmental sampling. These studies will result in a greater understanding of the underlying pathophysiology of CKDu.