Washington University Neurosurgery Resident Research Education Program

华盛顿大学神经外科住院医师研究教育计划

• 批准号: 10661573
• 负责人: GREGORY J ZIPFEL
• 金额: --
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661573
• 关键词: Academic Medical Centers; Academic Training; Award; Basic Science; Benchmarking; Caring; Clinical; Clinical Medicine; Clinical Research; Clinical Sciences; Communities; Country; Dedications; Development; Education; Education Projects; Ensure; Environment; Etiology; Extramural Activities; Face; Faculty; Feedback; Fellowship; Fostering; Funding; Future; Future Generations; Goals; Grant; Healthcare; Individual; Infrastructure; Institution; Instruction; K-Series Research Career Programs; Laboratories; Leadership; Mentors; Mentorship; Minority; Monitor; National Institute of Neurological Disorders and Stroke; Neurologic; Neurologist; Neurology; Neurosciences; Neurosciences Research; Neurosurgeon; Outcome Measure; Participant; Patients; Physicians; Positioning Attribute; Preparation; Private Practice; Process; Program Evaluation; Qualifying; Records; Research; Research Personnel; Research Support; Research Training; Residencies; Resources; Science; Scientist; Secure; Series; Structure; Time; Training; Translational Research; United States National Institutes of Health; Universities; Washington; Woman; candidate selection; career; career development; economic incentive; education research; experience; faculty mentor; improved; innovation; interest; medical schools; meetings; member; nervous system disorder; neurosurgery; next generation; programs; recruit; responsible research conduct; success

Abstract Young investigators are critical to maintaining the physician-scientist workforce, but keeping this pipeline robust faces a myriad of challenges. These include expanding bureaucracy, greater clinical demands, diminishing research time, rapid pace of advancement in basic science, and limited funding for research training. To create a more seamless pipeline for physician-scientist training in Neurosurgery and Neurology at Washington University School of Medicine (WUSM), we have established this Research Education Program that aims to train and develop the future generation of neurosurgeon- and neurologist-scientists essential for future advances in basic, translational, and clinical neuroscience. The structure of the Research Education Program proposed in this renewal application builds upon the strengths and successes of our original program, but changes it in one fundamental way – the program is now expanded to include both neurosurgery and neurology faculty and trainees. In the first iteration of our program, we focused solely on preparing neurosurgeon-scientists for independent investigative careers. In the current application, we now propose to prepare both neurosurgeon- and neurologist-scientists for investigative careers by enlisting full participation and leadership from the Department of Neurology at WUSM. What has not changed is the overarching goal of the WUSM Resident Education Program: to recruit and prepare the next generation of physician-neuroscientists so that they successfully compete for the best junior faculty positions in the country, secure extramural career development funding including K series grants from the NIH, and ultimately become highly successful physician-scientists. The Departments of Neurosurgery and Neurology at WUSM provide an excellent institutional environment for basic, translational, and clinical neuroscience research and education. Both departments have long and distinguished track records of training academic physician-neuroscientists spanning many decades. This success has been particularly strong over the past 10 years. In Neurosurgery, over 70% of graduates have entered academic practice and nearly 20% of graduates have become successful NIH-funded neurosurgeon- scientists. In Neurology, 66% of graduates have taken positions at academic medical centers, and 30% have received independent fellowship grants, K awards, and/or R01 grants. The proposed Neurosurgery and Neurology Research Education Program leverages our past educational experiences and the strong neuroscience community at WUSM in order to develop an enhanced and distinct research training pipeline, specifically for neurosurgeons and neurologists interested in academic careers as independent researchers, with the overall long-term goal of ensuring that highly-trained physician-scientists will be available to make future advances to reduce the burden of neurological diseases.

摘要 年轻的研究人员对于维持医生-科学家队伍至关重要，但也要保持这条管道的稳健 面临着无数的挑战。这些包括扩大官僚机构，更大的临床需求，减少 研究时间短，基础科学进展快，研究培训经费有限。要创建 华盛顿神经外科和神经病学的医生-科学家培训更无缝的管道 大学医学院(WUSM)，我们建立了这个研究教育计划，旨在培养 并培养下一代神经外科医生和神经病学家，这对未来在 基础神经科学、翻译神经科学和临床神经科学。 本次续展申请中提出的研究教育计划的结构建立在优势的基础上 和我们原始计划的成功，但在一个根本上改变了它-该计划现在得到了扩展 包括神经外科和神经病学的教职员工和实习生。在我们程序的第一次迭代中，我们将重点放在 仅仅是为了让神经外科医生和科学家为独立的调查职业做准备。在当前的应用程序中，我们 现在建议让神经外科医生和神经学家都为从事研究工作做好准备 WUSM神经病学系的参与和领导。没有改变的是 WUSM驻院教育计划的总体目标：招募和准备下一代 医生-神经科学家，这样他们才能成功地竞争全国最好的初级教员职位， 从NIH获得包括K系列补助金在内的校外职业发展资金，并最终成为 非常成功的内科科学家。 WUSM的神经外科和神经内科为 基础、转化和临床神经科学研究和教育。这两个部门都有很长的时间 数十年来培养学术内科医生-神经科学家的杰出记录。这 在过去的10年里，这种成功格外强劲。在神经外科，超过70%的毕业生 进入学术实践，近20%的毕业生成为成功的NIH资助的神经外科医生- 科学家们。在神经学方面，66%的毕业生曾在学术医学中心工作，30%的毕业生 获得独立研究金、K奖和/或R01奖。拟议的神经外科和 神经学研究教育计划利用我们过去的教育经验和强大的 WUSM的神经科学界，以开发一个增强的和独特的研究培训管道， 特别适合对学术生涯感兴趣的神经外科医生和神经学家作为独立研究人员， 总体的长期目标是确保训练有素的内科科学家将可用于制造未来 减轻神经系统疾病负担的进展。

项目成果

Endothelial nitric oxide synthase mediates endogenous protection against subarachnoid hemorrhage-induced cerebral vasospasm.

• DOI: 10.1161/strokeaha.110.607200
• 发表时间: 2011-03
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Vellimana AK;Milner E;Azad TD;Harries MD;Zhou ML;Gidday JM;Han BH;Zipfel GJ
• 通讯作者: Zipfel GJ

Sirtuin 1 Mediates Protection Against Delayed Cerebral Ischemia in Subarachnoid Hemorrhage in Response to Hypoxic Postconditioning.

• DOI: 10.1161/jaha.121.021113
• 发表时间: 2021-10-19
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Diwan D;Vellimana AK;Aum DJ;Clarke J;Nelson JW;Lawrence M;Han BH;Gidday JM;Zipfel GJ
• 通讯作者: Zipfel GJ

Completion of Gamma Knife radiosurgery for AVM treatment after unplanned interruption-technical note.

意外中断后完成伽玛刀放射外科治疗 AVM 技术说明。

• DOI: 10.1007/s00701-018-3493-0
• 发表时间: 2018
• 期刊: Acta neurochirurgica
• 影响因子: 2.4
• 作者: Raman,HariS;Santanam,Lakshmi;Vellimana,AnanthK;Drzymala,RobertE;Tsien,ChristinaI;Zipfel,GregoryJ
• 通讯作者: Zipfel,GregoryJ

Minocycline protects against delayed cerebral ischemia after subarachnoid hemorrhage via matrix metalloproteinase-9 inhibition.

• DOI: 10.1002/acn3.492
• 发表时间: 2017-12
• 期刊: Annals of clinical and translational neurology
• 影响因子: 5.3
• 作者: Vellimana AK;Zhou ML;Singh I;Aum DJ;Nelson JW;Harris GR;Athiraman U;Han BH;Zipfel GJ
• 通讯作者: Zipfel GJ

Early outcomes of the American Academy of Neurological Surgery Emerging Investigator Program in promoting neurosurgeon-scientists.

美国神经外科学会新兴研究者计划在促进神经外科医生科学家方面的早期成果。

• DOI: 10.3171/2022.5.jns212846
• 发表时间: 2022
• 期刊: Journal of neurosurgery
• 影响因子: 4.1
• 作者: Srienc,AnjaI;Church,SophieC;Korn,StephenJ;Lonser,RussellR;Zipfel,GregoryJ
• 通讯作者: Zipfel,GregoryJ