Suubi+Adherence-R2: Examining the longitudinal HIV treatment adherence among youth living with HIV (YLHIV) transitioning into young adulthood

Suubi Adherence-R2：检查青年艾滋病毒感染者 (YLHIV) 过渡到成年早期的纵向艾滋病毒治疗依从性

• 批准号: 10661567
• 负责人: Proscovia Nabunya
• 金额: $ 91.28万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661567
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Adolescent and Young Adult; Affect; Africa; Africa South of the Sahara; Alcohols; Area; Behavior; Biological; Caring; Child Development; Child Health; Clinic; Cognition; Cognitive; Cognitive deficits; Continuity of Patient Care; Country; Decision Making; Development; Drug Prescriptions; Economics; Enrollment; Failure; Family; Feeling hopeless; Female; HIV; HIV antiretroviral; HIV-associated neurocognitive disorder; HIV/AIDS; Health; Health behavior; Home; Incentives; Intervention; Life; Life Cycle Stages; Long-Term Effects; Maintenance; Marriage; Memory; Mental Depression; Mental Health; Mentorship; Outcome; Participant; Pharmaceutical Preparations; Phase; Prevalence; Prospective Studies; Randomized; Regimen; Reporting; Research; Research Priority; Resources; Risk; Risk Taking; Running; Rural; Sahara; Savings; Schools; Self Efficacy; Social support; Training; Uganda; United States National Institutes of Health; Viral; Viral Load result; Youth; aged; antiretroviral therapy; arm; cognitive development; cognitive function; cognitive testing; comorbidity; comparison control; comparison intervention; cost effectiveness; drug misuse; empowerment; evidence base; executive function; experience; financial literacy; high risk; improved; innovation; male; medical appointment; peer; primary outcome; programs; prospective; protective factors; psychologic; secondary analysis; sexual risk taking; social; social stigma; standard of care; theories; therapy adherence; transmission process; treatment adherence; treatment arm; two-arm study; young adult

PROJECT ABSTRACT This competing renewal to Suubi+Adherence study (R01HD074949) will examine the longitudinal HIV antiretroviral therapy (ART) adherence and related outcomes, and the potential mechanisms of protective health behaviors among youth living with HIV (YLHIV) who participated in an evidence-based family economic empowerment (FEE) intervention in Uganda and are now transitioning into young adulthood. Sub-Saharan Africa (SSA) has the highest HIV prevalence rate in the world. In Uganda, a poor SSA country hardest hit with HIV, the prevalence of viral load suppression among adolescents and young adults (15 to 24 years old) is 44.9% for females and 32.5% for males. For six years (2012-2018), the Suubi+Adherence study prospectively followed 702 YLHIV (aged 10 to 16 years at enrollment) randomized to two study arms across 39 clinics in Uganda: 1) control arm consisting of bolstered standard of care (BSOC) and 2) intervention arm consisting of BSOC and a FEE intervention. Study findings pointed to superior short-term viral suppression and positive child health and mental health functioning among the intervention arm. This renewal (Suubi+Adherence-Round 2) proposes to examine whether the results are maintained through young adulthood, an incredibly vulnerable transition period, particularly in areas of adherence to HIV treatment, cognitive development, mental health, sexual risk taking behaviors and alcohol/drug misuse. The renewal (2020-2025) will build on the Suubi+Adherence study to conduct one of the largest and longest running studies of YLHIV in SSA during a developmental period marked by profound biological and psychological maturation, and development transitional milestones. In this next phase, we will add a qualitative component to examine participants' experiences with the FEE program as well as long-term effects. Innovatively, we will also assess the impact of the FEE on cognitive functioning. The study specific aims are: Aim 1. To examine the long-term impact of the Suubi+Adherence intervention on: HIV viral suppression (primary outcome) and to explore the long-term impact of the intervention on key HIV treatment adherence outcomes for YLHIV, including participants' ability to access and refill prescribed medication, adhere to prescribed daily medication routines, and engage in HIV care; Aim 2. To elucidate the long-term effects of the Suubi+Adherence intervention on potential mechanisms of change, including: a) economic stability, sexual risk- taking behavior, adherence self-efficacy; b) cognitive functioning; c) mental health functioning; and d) young adult transitions and social support; Aim 3. To qualitatively examine– prospectively and retrospectively: a) multi- level factors affecting participants' maintenance of intervention benefits since Suubi+Adherence intervention initiation (prospectively); and b) participants' experiences with the intervention (retrospectively), including multi- level factors that may have influenced their engagement with the program and their decision-making in regard to ART adherence; Aim 4. To examine the long-term cost-effectiveness of the Suubi+Adherence intervention. The study is aligned with the National Institutes of Health Office of AIDS Research priorities.

项目摘要

项目成果

Evaluating the literature of therapeutic landscapes with an emphasis on the search for the dimensions of health: A systematic review.

• DOI: 10.1016/j.socscimed.2021.113820
• 发表时间: 2021-03
• 期刊: Social science & medicine
• 影响因子: 5.4
• 作者: Shima Taheri;Maryam Ghasemi sichani;A. Shabani

The effect of family support on self-reported adherence to ART among adolescents perinatally infected with HIV in Uganda: A mediation analysis.

• DOI: 10.1002/jad.12157
• 发表时间: 2023-06
• 期刊: JOURNAL OF ADOLESCENCE
• 影响因子: 3.8
• 作者: Nabunya, Proscovia;Samuel, Kizito;Ssewamala, Fred M
• 通讯作者: Ssewamala, Fred M

A Cluster-Randomized Controlled Trial of an Economic Strengthening Intervention to Enhance Antiretroviral Therapy Adherence among Adolescents Living with HIV.

• DOI: 10.1007/s10461-024-04268-4
• 发表时间: 2024-01-17
• 期刊: AIDS AND BEHAVIOR
• 影响因子: 4.4
• 作者: Kizito，Samuel;Namuwonge，Flavia;Ssewamala，Fred M.
• 通讯作者: Ssewamala，Fred M.

Using Hierarchical Regression to Examine the Predictors of Sexual Risk-Taking Attitudes among Adolescents Living with Human Immunodeficiency Virus in Uganda.

• DOI: 10.1016/j.jadohealth.2023.02.034
• 发表时间: 2023-08
• 期刊: JOURNAL OF ADOLESCENT HEALTH
• 影响因子: 7.6
• 作者: Kizito, Samuel;Namuwonge, Flavia;Nabayinda, Josephine;Nabunya, Proscovia;Nattabi, Jennifer;Bahar, Ozge Sensoy;Kiyingi, Joshua;Magorokosho, Natasja;Ssewamala, Fred M.
• 通讯作者: Ssewamala, Fred M.

Adaptation and Validation of the Shame Questionnaire Among Ugandan Youth Living with HIV.

乌干达艾滋病毒青年羞耻调查问卷的改编和验证。

• DOI: 10.1007/s12187-018-9570-3
• 发表时间: 2019
• 期刊: Child indicators research
• 影响因子: 2.8
• 作者: Michalopoulos,LynnMurphy;Meinhart,Melissa;Barton,SamMonroe;Kuhn,Jillian;Mukasa,MiriamN;Namuwonge,Flavia;Feiring,Candice;Ssewamala,FredM
• 通讯作者: Ssewamala,FredM