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Acoustic Cavitation Emission (ACE) Feedback Methods for Monitoring Histotripsy-Induced Tissue Fractionation In Situ

用于监测组织解剖诱导的原位组织分割的声空化发射 (ACE) 反馈方法

基本信息

批准号：
10670176
负责人：
Jonathan Robert Sukovich
金额：
$ 53.08万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670176
关键词：
Ablation Acoustics Affect Algorithms Animal Model Blood coagulation Brain Clinical Clinical Trials Data Deposition Development Dose Elements Ensure Erythrocytes Europe Event Exposure to Family suidae Feedback Focused Ultrasound Therapy Fractionation Future Gel Generations Heating Histologic Histology Human Hydrogels Image In Situ Kidney Literature Liver Location Measures Mechanics Methods Modality Monitor Operative Surgical Procedures Optics Outcome Pathology Patients Phase Physiologic pulse Prediction of Response to Therapy Procedures Process Property Prostate Radiation Radiation Dose Unit Radiation Toxicity Radiation therapy Radiofrequency Interstitial Ablation Safety Secondary to Secure Signal Transduction Spleen System Techniques Technology Thermometry Time Tissues Treatment Efficacy Ultrasonic Therapy Ultrasonography Visual Work clinical translation cranium efficacy validation experimental study in vivo liver tumor ablation mechanical properties mechanical signal outcome prediction porcine model prediction algorithm rib bone structure risk minimization side effect therapy outcome transmission process ultrasound

项目摘要

PROJECT SUMMARY/ABSTRACT Histotripsy is a non-invasive, ultrasound based tissue ablation therapy which relies on the targeted generation of cavitation events to mechanically fractionate and liquefy tissues. Quantifiable metrics by which the outcomes of histotripsy therapy can be predicted as a function of therapy inputs are essential for ensuring reliable and repeatable treatments, but do not currently exist. Although histotripsy-generated cavitation and liquefied tissue can be detected in ultrasound imaging, there is no established metric to quantify induced tissue damage versus cavitation exposure, which is known to vary with tissue properties, as well as among patients. With clinical translation of histotripsy ongoing, it is critical to establish a dose metric by which cavitation energy deposited to tissue during histotripsy can be monitored in situ to accurately predict therapy-generated damage. In this project we propose to develop metrics for monitoring histotripsy-induced tissue fractionation by monitoring the acoustic cavitation emission (ACE) signals generated by the cavitation events responsible for therapy during histotripsy. The ACE signals encode information about the dynamics and energetics of the cavitation events from which they are emitted, which depend on the mechanical properties/integrity of the media in which the cavitation events were generated. As a result of exposure to cavitation during histotripsy, targeted materials are mechanically disrupted which alters their mechanical properties, which can thus affect the dynamics of the cavitation events. By developing methods to monitor features of the ACE signals the mechanical state of the material in which the cavitation events were generated can be assessed in situ. We will carry out experiments in which histotripsy will be used to generate cavitation in a range of tissue- mimicking gel phantoms and tissues with a wide range of mechanical properties to ablate them. During treatment, the ACE signals will be recorded. Following treatment, generated damage will be assessed optically and histologically and the recorded ACE signals will be analyzed to identify the features in them that can be correlated with the induced damage observed in images or histology. Establishing such correlations will allow the ACE signals to be used as a metric for monitoring induced material fractionation during histotripsy treatment. To enable robust monitoring, the ACE signals can be monitored using the transmitting elements of the array as receivers in addition to hydrophones. This will ensure that an acoustically accessible path to the generated cavitation events will always be available to provide accurate monitoring of the ACE signals, but will require the development of sophisticated real-time algorithms to process owing to the large amount of data that will be generated. Once correlations between features of the ACE signals and induced damage in gel phantoms and ex vivo tissues have been identified, and real-time algorithms for monitoring them developed, they will be validated in vivo in a swine model. The results of this work will be essential for establishing a histotripsy dose metric and for histotripsy to obtain FDA approval for clinical use.

项目总结/文摘