SWG 11: Substance Use

项目摘要/摘要 物质使用科学工作组(SU SWG)的提出是为了促进跨学科科学 合作调查药物使用和艾滋病毒的交叉问题，这是一个至关重要的领域，需要彻底解决 全国和全球的艾滋病毒流行。人们对加强对物质的研究重新产生了兴趣和紧迫性 使用和艾滋病毒，部分原因是阿片类药物危机与美国部分地区的艾滋病毒爆发有关，包括 西雅图，以及冰毒使用率的上升，与高危性行为有关。此外， 物质使用仍然强烈地推动艾滋病毒护理连续体系中的中断和差距，包括继续 在艾滋病毒护理和坚持“治疗即预防”所需的抗逆转录病毒疗法方面。苏世民将带来 来自不同背景的CFAR调查人员在解决面临的独特问题方面有着共同的兴趣 艾滋病毒携带者或有感染风险的药物使用障碍者，特别是注射吸毒者(PWID) 他们是一个关键的弱势群体。SU SWG解决了NIH艾滋病毒优先发展的一个关键领域 它检查健康和社会问题，如其他传染性或非传染性疾病和物质使用 或精神健康障碍“。我们将支持研究，以了解当前的物质和 多物质使用，包括阿片类药物、兴奋剂、镇静剂、大麻、酒精和尼古丁 艾滋病毒携带者和感染艾滋病毒风险者，并阐明它们对艾滋病毒疾病传播的影响 和疾病爆发。我们还将促进研究，以开发和测试以患者为中心的干预措施，包括生物医学 和行为学，这将预防和/或治疗有物质使用障碍的人的艾滋病毒和研究 这将把对成瘾和艾滋病毒的护理结合起来。我们的首要目标是将一个多学科的 致力于推进药物使用和艾滋病毒预防研究议程的研究人员社区， 治疗和治愈。我们的具体目标是：1)创建和支持UW的多学科网络 具有不同背景和专业知识的研究人员，以开发物质使用研究并获得 对项目和赠款的批判性反馈。2)培养与物质使用有关的新技能和知识 在早期研究人员和那些艾滋病毒或药物使用研究的新手中进行艾滋病毒研究， 特别是那些来自不同和代表性不足的背景的人。我们将利用并创造 在我们的CFAR上，不同研究人员之间关于物质使用的多学科合作，每月支持 工作进行中的会议，并主办专门针对交叉口的技能发展年度研讨会 物质使用和艾滋病毒之间的关系。我们的努力将包括集中努力支持早期调查人员。 这项工作将与CFAR社区参与办公室合作完成，以确保 讨论了社区的优先事项。有了这个新的SWG，我们将利用实质性的势头积累 围绕预防艾滋病毒和改善对药物使用和使用障碍患者的艾滋病毒护理的研究，以 将我们的CFAR定位为物质使用和艾滋病毒领域的领导者。

Project Summary/Abstract The Substance Use Scientific Working Group (SU SWG) is proposed to stimulate interdisciplinary scientific collaboration to investigate the intersection of substance use and HIV, an area that is critical to address to end the national and global HIV epidemics. There is renewed interest and urgency to enhance research on substance use and HIV, in part due to the opioid crisis being associated with HIV outbreaks in parts of the US, including Seattle, and increasing rates of methamphetamine use, being associated with high-risk sex. Furthermore, substance use still strongly drives disruptions and disparities in the HIV care continuum, including continuation in HIV care and adherence to ART which are needed for “treatment as prevention”. The SU SWG will bring together CFAR investigators from varied backgrounds with a shared interest in tackling the unique issues facing persons with substance use disorders living with, or at risk for, HIV, particularly people who inject drugs (PWID) who are a key vulnerable population. The SU SWG addresses a key NIH HIV priority area furthering “research that examines health and social issues, such as other infectious or non-infectious conditions and substance use or mental health disorders”. We will support research to understand current patterns of substance and polysubstance use, including opioids, stimulants, sedatives, cannabis, alcohol, and nicotine, among persons living with HIV and those at risk of acquiring HIV, and to elucidate how they impact HIV disease transmission and outbreaks. We will also foster research to develop and test patient-centered interventions, both biomedical and behavioral, that will prevent and/or treat HIV among persons with substance use disorders and research that will integrate care for addictions and HIV. Our overarching goal is to bring together a multi-disciplinary community of researchers dedicated to advancing the research agenda for substance use and HIV prevention, treatment, and cure. Our Specific Aims are to: 1) create and support a multi-disciplinary network of UW researchers with diverse backgrounds and expertise to develop substance use research and receive critical feedback on projects and grants. 2) cultivate new skills and knowledge related to substance use and HIV research among early stage investigators and those new to HIV or substance use research, particularly those from diverse and underrepresented backgrounds. We will leverage and create multidisciplinary collaborations between diverse researchers on substance use at our CFAR, support monthly work-in-progress meetings, and host an annual workshop for skills development specific to the intersection between substance use and HIV. Our efforts will include a focused effort to support early stage investigators. This work will be done in collaboration with the CFAR Office of Community Engagement to ensure that community priorities are addressed. With this new SWG, we will leverage the substantial momentum building around research on HIV prevention and improved HIV care for persons with substance use and use disorders to position our CFAR to be a leader in the field of substance use and HIV.