Consortium for the study of chronic pancreatitis, diabetes and pancreatic cancer: Pittsburgh Clinical Center

慢性胰腺炎、糖尿病和胰腺癌研究联盟：匹兹堡临床中心

• 批准号: 10684422
• 负责人: Randall Brand
• 金额: $ 10万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684422
• 关键词: Address; Ancillary Study; Animal Model; Area; Bioinformatics; Biological; Biological Markers; Biometry; Categories; Clinical; Clinical Research; Clinical Trials; Collaborations; Data; Data Reporting; Development; Diabetes Mellitus; Diagnosis; Disease; Disease Progression; Effectiveness; Endocrinology; Enrollment; Ensure; Enzyme-Linked Immunosorbent Assay; Epidemiology; Extramural Activities; Faculty; Funding; Future; Genes; Genotype; Goals; Image; Individual; Inflammatory; Infrastructure; Knowledge; Lead; Leadership; Longevity; Malignant neoplasm of pancreas; Measures; Modeling; Morbidity - disease rate; Multicenter Studies; Mutate; National Institute of Diabetes and Digestive and Kidney Diseases; Pain; Pancreas; Pancreatic Diseases; Pancreatic Ductal Adenocarcinoma; Pancreatitis; Participant; Pathogenesis; Patients; Phenotype; Physiology; Prognosis; Publications; Publishing; Quality of life; Randomized Clinical Trials; Recurrence; Research; Research Infrastructure; Research Personnel; Resources; Risk; SNP array; Sampling; Screening for cancer; Site; Structure; Teacher Professional Development; Therapeutic; Universities; Urine; Work; acute pancreatitis; authority; base; biobank; biomarker signature; cancer genetics; chronic pancreatitis; clinical center; clinical infrastructure; clinical practice; clinically translatable; cohort; data exchange; data management; design; disorder subtype; experience; faculty research; follow-up; high risk; instrument; member; multidisciplinary; novel; organizational structure; predictive modeling; prevent; prognostication; programs; success; targeted sequencing; tool; translational study; working group

Abstract. Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center. The Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center (PCC) is a multidisciplinary clinical- translational program at the University of Pittsburgh and UPMC. The PCC is one of the 10 founding members of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC). The organizational structure of PCC allows comprehensive epidemiological, clinical and biological characterization of patients with pancreatic disorders in order to conduct clinical, translational and mechanistic studies of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and their sequelae such as Type 3c diabetes and pancreatic cancer. The PCC is highly integrated at all levels of the CPDPC, including leadership, participation in Committees and Working Groups, contribution to primary cohorts, several ancillary studies and publications. PCC has been effective in utilizing the CPDPC infrastructure and resources for high-quality scientific projects. In the next five years of funding, the PCC is committed to completing ascertainment of the primary CPDPC cohorts, execution of the currently approved ancillary studies, and participating in new projects. We will also propose concepts for three new ancillary studies that will utilize the infrastructure and resources of the CPDPC. Our specific aims are: Aim 1. Contribute to completing the acquisition of CPDPC’s primary cohorts and ongoing ancillary studies. Aim 2. We will propose and support new ancillary projects to use the infrastructure created with the primary cohorts and ongoing ancillary studies. As part of Aim 2, we propose concepts for three ancillary projects, to – i) Develop a Chronic Pancreatitis Risk Score (CPRS) for use in randomized clinical trials of CP, ii) Identify Urine Biomarkers of Pain (UBP) for mechanism-based phenotyping of CP pain, and iii) Use a genotying approach to enrich the New Onset Diabetes (NOD) cohort. Our existing and well-established, efficient and effective clinical and research infrastructure for patient accrual, sample processing, data management and transfer, and analysis will support the program. The rich clinical volume, diverse investigator expertise in all critical areas such as pancreatology, epidemiology, early detection of cancer, genetics, physiology, imaging, endocrinology, biostatistics and bioinformatics, and all relevant disease subtypes, administrative authority in clinical and research areas ensure continued success. Our track record of leadership, strong collaborations and working relationships within the CPDPC and other collaborative networks will also ensure continued success and effectiveness of the CPDPC.

抽象的。 胰腺炎研究联盟：匹兹堡临床中心。 胰腺炎研究联盟：匹兹堡临床中心(PCC)是一个多学科的临床- 匹兹堡大学和UPMC的翻译课程。中国人民政治协商会议是10个创始成员之一 慢性胰腺炎、糖尿病和胰腺癌研究联盟(CPDPC)。这个 PCC的组织结构允许全面的流行病学、临床和生物学特征 对胰腺疾病患者进行临床、翻译和机制研究 复发性急性胰腺炎(RAP)和慢性胰腺炎(CP)及其后遗症如3c型糖尿病 和胰腺癌。政协在政协各级高度整合，包括领导班子， 参加委员会和工作组、对主要队列的贡献、若干辅助研究和 出版物。PCC有效地利用了CPDPC的基础设施和资源，以实现高质量 科学项目。在未来五年的拨款中，公众投诉委员会致力于完成 主要的CPDPC队列，执行目前批准的辅助研究，并参与新的 项目。我们还将提出三项新的辅助研究的概念，这些研究将利用基础设施和 国家发改委的资源。我们的具体目标是：目标1.为完成对CPDPC的收购做出贡献 主要队列和正在进行的辅助研究。目标2.我们会提出和支持新的附属项目，以 使用与主要队列和正在进行的辅助研究一起创建的基础设施。作为目标2的一部分，我们 提出三个辅助项目的概念，以：i)制定慢性胰腺炎风险评分(CPRS)以供使用 在CP的随机临床试验中，II)确定尿痛的生物标志物(UBP)以机制为基础 CP疼痛的表型，以及iii)使用基因分型方法来丰富新发糖尿病(NOD)队列。 我们现有和完善的、高效和有效的临床和研究基础设施，用于患者收益， 样品处理、数据管理和传输以及分析将为该计划提供支持。丰富的临床 数量庞大，在所有关键领域，如胰脏病学、流行病学、早期发现等领域都有不同的研究人员专业知识 癌症，遗传学，生理学，成像，内分泌学，生物统计学和生物信息学，以及所有相关的 疾病亚型、临床和研究领域的管理权威确保了持续的成功。我们的赛道 在国家发改委和其他协作性组织内具有领导能力、良好的协作能力和工作关系 网络还将确保国家发改委继续取得成功和成效。