Ultrasound-guided Intrinsic Threshold Histotripsy for the Non-invasive Ablation of Uterine Fibroids
Ultrasound-guided Intrinsic Threshold Histotripsy for the Non-invasive Ablation of Uterine Fibroids
批准号:
10684104
负责人:
Eli Vlaisavljevich
金额:
$23.1万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-08-15 至 2024-07-31
关键词:
AblationAcousticsAcuteAdoptionAdverse eventAftercareAgeAnimal ModelBehaviorBenignCartilageChronicCicatrixConvalescenceDevelopmentDiseaseExcisionFibroadenomaFibroid TumorFocused UltrasoundFocused Ultrasound TherapyGoalsHospitalizationHumanHysterectomyImmune responseInflammatory ResponseLeiomyomaMagnetic Resonance ImagingMechanicsMethodsModelingNecrosisNerveOperative Surgical ProceduresOutcomePatient-Focused OutcomesPhysiologic pulseProceduresPropertyRecoveryResearchResolutionRodent ModelSafetyShapesShockStructureSymptomsTechniquesTendon structureThermal Ablation TherapyTimeTissuesTranslationsUltrasonographyUterine FibroidsUterusWomanWorkbile ductclinical applicationexperimental studyimage guidedimprovedin vivoin vivo evaluationmillimeterpreservationpreventrapid techniquereal-time imagesreproductivereproductive functionsoft tissuetissue phantomtreatment optimizationtreatment responsetumorultrasound
中文摘要
项目概要
该项目的目标是开发内阈组织解剖学作为非热聚焦超声 (FUS)
子宫肌瘤无创消融技术。子宫肌瘤(平滑肌瘤)是最常见的
育龄妇女良性肿瘤,导致超过 250,000 人住院,200,000 人死亡
每年进行子宫切除术。子宫肌瘤的黄金标准是子宫切除术,这是一种外科手术,
需要延长住院和康复时间,并导致生殖功能丧失。热学
FUS 已成为一种管理和保护子宫功能的非侵入性方法。然而,
热扩散引起的并发症、依赖 MRI 进行图像引导、治疗时间慢以及治疗速度慢
治疗后肌瘤的吸收限制了热FUS的广泛使用。这个提议
开发了用于子宫肌瘤消融的内在阈值组织解剖学。虽然组织病理学显示
该技术有可能克服许多临床应用中热消融的局限性
已被证明在高纤维组织中效果较差,迄今为止这阻碍了组织解剖学的应用
开发用于治疗子宫肌瘤。最近,我们的团队完成了一项概念验证研究,证明
组织解剖学可以使用内在阈值组织解剖学技术有效地消融人类子宫肌瘤。在
在这个项目中,我们将研究快速消融子宫肌瘤的最佳组织解剖治疗方法
在实时超声图像引导下。在目标 1 中,我们将比较组织解剖空化气泡云
多周期(冲击散射组织解剖)和单周期(内在
阈值组织解剖)方法使用各种潜在的组织解剖脉冲参数。实验将
可以在机械可调的组织模型中进行,该模型模仿纤维组织的特性以及前
使用切除的人子宫肌瘤进行体内实验。在目标 2 中,我们将测试内在的安全性和有效性
小动物模型中的阈值组织解剖消融。这些目标的成功实现将证明
TEH 无创治疗子宫肌瘤的安全性和有效性。
英文摘要
PROJECT SUMMARY
The goal of this project is to develop intrinsic threshold histotripsy as a non-thermal focused ultrasound (FUS)
technique for the non-invasive ablation of uterine fibroids. Uterine fibroids (leiomyomas) are the most common
benign tumors in women of reproductive age, resulting in over 250,000 hospital admissions and 200,000
hysterectomies annually. The gold standard for uterine fibroids is hysterectomy, a surgical procedure that
requires extended hospitalization and recovery time, and results in the loss of reproductive function. Thermal
FUS has emerged as a non-invasive method for the management and conservation of uterine function. However,
complications due to thermal spread, reliance on MRI for image-guidance, slow treatment times, and slow
resorption of the fibroids after treatment have limited the widespread use of thermal FUS. This proposal
develops intrinsic threshold histotripsy for the ablation of uterine fibroids. While histotripsy has shown the
potential to overcome limitations of thermal ablation in many clinical applications, the technique has previously
been shown to be less effective in highly fibrous tissues, which has thus far prevented histotripsy from being
developed for treating uterine fibroids. Recently, our team completed a proof-of-concept study demonstrating
that histotripsy can effectively ablate human uterine fibroids using intrinsic threshold histotripsy techniques. In
this project, we will investigate the optimal histotripsy treatment methods for the rapid ablation of uterine fibroids
under real-time ultrasound image-guidance. In Aim 1, we will compare the histotripsy cavitation bubble cloud
behavior and tissue ablation generated by multi-cycle (shock-scattering histotripsy) and single-cycle (intrinsic
threshold histotripsy) methods using a wide range of potential histotripsy pulsing parameters. Experiments will
be conducted in mechanically-tunable tissue phantoms that mimic the properties of fibrous tissue as well as ex
vivo experiments using excised human uterine fibroids. In Aim 2, we will test in vivo safety and efficacy of intrinsic
threshold histotripsy ablation in a small animal model. The successful completion of these aims will demonstrate
the safety and efficacy of TEH for the non-invasive treatment of uterine fibroids.
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Ultrasound-guided Intrinsic Threshold Histotripsy for the Non-invasive Ablation of Uterine Fibroids
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批准号:10509018
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项目类别:
-
资助金额:$19.12万
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财政年份:2022
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负责人:Eli Vlaisavljevich
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依托单位:
Nanoparticle-mediated Histotripsy (NMH) for Noninvasive and Targeted Ablation of Metastatic Breast Cancer
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批准号:10376030
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项目类别:
-
资助金额:$18.47万
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财政年份:2020
-
负责人:Eli Vlaisavljevich
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依托单位:
Nanoparticle-mediated Histotripsy (NMH) for Noninvasive and Targeted Ablation of Metastatic Breast Cancer
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批准号:9895896
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项目类别:
-
资助金额:$19.04万
-
财政年份:2020
-
负责人:Eli Vlaisavljevich
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依托单位:
海外基金