Improving Opioid Use Disorder Treatment for Hospitalized Patients with Endocarditis

项目总结/摘要 因阿片类药物使用障碍相关感染性心内膜炎（OUD-IE）住院的患者， 结果和高成本。尽管阿片类药物使用障碍的有效治疗是可行的， 在住院期间进行干预，医疗保健人员往往不会在住院期间解决阿片类药物使用障碍 为了OUD-IE。阿片类药物使用障碍患者的现有医院护理模式可以为医院护理提供信息 对于OUD-IE患者，尽管需要对这些模型进行重大调整以满足OUD的独特需求， IE患者与其住院时间延长有关。关于如何最好地部署基于证据的 阿片类药物使用障碍的干预措施，为医疗住院患者。拟议研究的目的是：1） 描述卫生保健工作人员目前为OUD-IE患者提供医院护理的做法; 2） 检查实施循证阿片类药物使用障碍的适当性，可行性和可接受性 护理住院OUD-IE患者; 3）适应住院OUD-IE患者的干预措施， 相应的执行战略工具包。为了实现这些目标，我将让卫生保健工作人员 谁照顾OUD-IE病人在宾夕法尼亚大学医院，并将依靠导师， 来自宾夕法尼亚大学护理学院和医学院的合作者。定性数据， 将结合专家意见，为调整阿片类药物使用障碍干预措施提供信息， OUD-IE患者和相应的实施策略工具包。这项研究的结果将增加 目前对阿片类药物使用障碍住院患者提供护理的疗效有限， 加强他们的成果。这一研究方案和相应的培训活动将促进 申请人追求学术研究事业的长期目标，致力于提高护理质量 以及通过实施科学对患有物质使用障碍的住院患者的结果。具体 培训目标是：1）了解OUD住院患者护理的现行做法; 2） 为拟议项目和未来研究的方法奠定坚实的基础; 3）发展相关技能 设计和实施新的做法在医院;和4）整合专业发展，补助金 写作和奖学金，准备成为一名独立的研究人员。

PROJECT SUMMARY/ABSTRACT Patients hospitalized for opioid use disorder-associated infective endocarditis (OUD-IE) have distinctly poor outcomes and high costs. Despite the availably of effective treatment for opioid use disorder and the opportunity to intervene during hospitalization, health care staff tend not to address opioid use disorder during hospitalization for OUD-IE. Existing models of hospital care for patients with opioid use disorder can inform hospital care delivery for OUD-IE patients, though significant adaptation of these models is needed to meet the unique needs of OUD- IE patients related to their prolonged hospital stays. Little is known regarding how to best deploy evidence-based opioid use disorder interventions for medically hospitalized patients. The aims of the proposed study are to: 1) Characterize current practices of health care staff regarding hospital care delivery for OUD-IE patients; 2) Examine the appropriateness, feasibility, and acceptability of implementing evidence-based opioid use disorder care for hospitalized OUD-IE patients; and 3) Adapt an intervention for hospitalized OUD-IE patients and develop a corresponding toolkit of implementation strategies. To accomplish these aims, I will engage health care staff who care for OUD-IE patients at the Hospital of the University of Pennsylvania and will rely on mentorship and collaborators from faculty in the University of Pennsylvania's Schools of Nursing and Medicine. Qualitative data, in conjunction with expert opinion, will be integrated to inform an adapted opioid use disorder intervention for OUD-IE patients and a corresponding toolkit of implementation strategies. Findings from this study will increase the currently limited efficacy of care delivery for hospitalized patients with opioid use disorder and ultimately enhance their outcomes. This program of research and corresponding training activities will facilitate the applicant's long-term goal of pursuing an academic research career committed to improving the quality of care and outcomes for hospitalized people with substance use disorders through implementation science. Specific training goals are to: 1) Understand current practices for care delivery for hospitalized patients with OUD; 2) Acquire a strong foundation in methods for the proposed project and for future research; 3) Develop skills related to designing and implementing new practices in hospitals; and 4) Integrate professional development, grant writing, and scholarship to prepare to be an independent researcher.