Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease

项目摘要 我们建议继续一个非常成功的分子生物学培训计划 神经退行性变和阿尔茨海默病-一个致力于培训预科和预科医生的项目 博士后在大学和健康相关领域从事独立研究 研究实验室。培训者都是哈佛大学的教职员工，他们都有积极的研究项目 与神经退行性变有关，重点是阿尔茨海默病和其他神经退行性疾病 与衰老有关的疾病。他们来自哈佛医学院和五个附属机构 研究医院：贝丝·以色列-女执事医疗中心，布里格姆和妇女医院， 儿童医院、达纳-法伯癌症研究所和马萨诸塞州综合医院。带来了一个 处理与年龄有关的问题的广泛经验和实验方法 神经退行性疾病，该计划的教职员工包括分子生物学家、遗传学家、细胞生物学家、 神经病理学家和生物化学家。 博士前招生从研究生中招收和抽取 哈佛医学院神经科学学位授予计划。博士后 是从该项目的个别教员提名的申请者中挑选出来的。 学员的选择是通过由培训补助金咨询协调的竞争过程进行的 委员会审议阶段。共有6名博士后实习生和8名博士后实习生拟参加 25名在年龄相关的基础和应用研究方面经验丰富的初级培训人员 神经退行性变。成功应聘者的主要标准是敬业精神和对衰老的兴趣 和神经退行性研究以及他们之前最高水平的学术成就 训练。学生被要求参加特殊的神经变性课程、研讨会和 座谈会。对学生进步的密切监控和职业建议为 整个训练过程。该计划的目的是建立一个框架，在这个框架内 对致力于衰老和神经变性问题的未来研究人员进行最好的培训 地点，计划教职员工之间已经广泛的协作交互可以是 在各级进行宣传，从学生到教授。

Project Abstract We propose to continue a highly successful Training Program in the Molecular Biology of Neurodegeneration and Alzheimer’s disease - a program devoted to the training of pre- and postdoctoral students for careers as independent research scientists in universities and health-related research laboratories. The trainers are all Harvard faculty members with active research programs related to neurodegeneration, with an emphasis on Alzheimer’s disease and other neurodegenerative disorders related to aging. They are drawn from the Harvard Medical School and five affiliated research hospitals: Beth Israel-Deaconess Medical Center, Brigham and Women’s Hospital, Children’s Hospital, Dana-Farber Cancer Institute, and Massachusetts General Hospital. Bringing a wide range of experience and experimental approaches to the problems of age-related neurodegeneration, the Program faculty includes molecular biologists, geneticists, cell biologists, neuropathologists, and biochemists. The predoctoral students are recruited into and drawn from the graduate students in the degree-granting Neuroscience Program of the Harvard Medical School. The postdoctoral students are chosen from among applicants nominated by individual faculty members of the Program. Selection of trainees occurs through a competitive process mediated by a Training Grant Advisory Committee. A total of six predoctoral trainees and eight postdoctoral trainees are proposed for a primary training faculty of 25 individuals experienced in basic and applied studies of age-related neurodegeneration. The main criteria for successful candidates is dedication and interest in aging and neurodegeneration research and the highest level of academic achievement in their previous training. Students are required to participate in special neurodegeneration courses, seminars, and symposia. Close monitoring of student progress and career advising provide an effective structure for the entire training process. The purpose of the Program is to create a framework within which the best training of future researchers devoted to problems in aging and neurodegeneration can take place, and the already extensive collaborative interactions among the Program faculty can be propagated at all levels, from student to Professor.