Implementation Science Core [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]

实施科学核心 [父标题：在马拉维通过实施科学预防婴儿感染]

• 批准号: 10701193
• 负责人: Brian W Pence
• 金额: $ 20.31万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701193
• 关键词: Address; Applied Research; Breast Feeding; Clinical Sciences; Data Collection; Development; Ensure; Evaluation; Evidence based intervention; Fellowship; Funding; Goals; Guidelines; HIV; Institution; International; Internships; Intervention; Knowledge; Learning; Malawi; Manuscripts; Measurement; Mental Health; Mentors; Monitor; North Carolina; Outcome; Parents; Prevention; Research; Research Design; Research Personnel; Research Project Grants; Resources; Science; Scientist; Series; Testing; Training; Training Programs; Translating; Translational Research; Translations; United States National Institutes of Health; Validation; Vertical Disease Transmission; Wit; Woman; doctoral student; evidence base; experience; implementation evaluation; implementation facilitation; implementation intervention; implementation measures; implementation outcomes; implementation research; implementation science; implementation strategy; improved; infant infection; innovation; meetings; member; organizational readiness; postnatal; prevent; programs; protocol development; real world application; scale up; skills; synergism; tool

Implementation Science Core – Summary Many interventions have been developed and tested for elimination of mother-to-child transmission but the translation and implementation of these interventions into real-world settings has remained limited. Implementation science provides the necessary tools to ensure that interventions are implemented well and their impact in real-world settings is realized. The goal of the implementation science core is to provide scientific support to each of the PRI3SM implementation science research projects to ensure the latest principles and approaches in implementation science are applied appropriately to maximize the impact of the research projects through the following aims: Aim 1. To provide support and resources to enable investigators at UNC Project Malawi to effectively implement evidence-based EMTCT interventions. The implementation science core will provide assistance with selection and application of implementation science study designs to guide protocol development; identification, selection, and adaptation of implementation strategies to facilitate implementation of PRI3SM projects; selection of appropriate implementation outcomes and assistance in the development and validation of data collection tools for measuring implementation outcomes of the PRI3SM projects; implementation, monitoring and evaluation of evidence-based PRI3SM interventions in real-world settings; identification of key barriers and facilitators to implementing PRI3SM interventions; organizational readiness assessments for implementation of the PRI3SM projects and supporting qualitative measurement of implementation science outcomes and construct such as acceptability, feasibility, barriers and facilitators and organizational readiness. Aim 2: To provide trainees and junior investigators from existing local IS training programs with opportunities for real-world application of implementation science concepts. The Implementation Science Core will provide internship and fellowship placements and mentored experiential training in implementation science for junior investigators such as master’s and PhD students and graduates from existing implementation science training programs. The Implementation Science Core will leverage the capacity building program for PRI3SM to fully establish an Implementation Science Unit at UNC Project Malawi for ongoing support with implementation science training and resources. The ongoing support will include formal meetings and a seminar series with trainees to provide a platform for exchange of skills and experiences, presentations on projects and relevant implementation science topics, and review of manuscripts.

实施科学核心-摘要 已经开发和测试了许多用于消除母婴传播的干预措施，但 将这些干预措施转化和实施到现实世界中的情况仍然有限。 实施科学提供了必要的工具，以确保干预措施得到很好的实施 它们在现实世界环境中的影响是实现的。实施科学核心的目标是提供 为每个PRI3SM实施的科研项目提供科学支持，以确保最新的 适当应用实施科学中的原则和方法，以最大限度地发挥 通过以下目标开展的研究项目： 目标1.提供支持和资源，使北卡罗来纳大学马拉维项目的调查人员能够有效地 实施循证的母婴传播干预措施。执行科学核心将提供协助 选择和应用实施科学研究设计，以指导议定书的制定； 确定、选择和调整实施战略，以促进实施PRI3SM 项目；选择适当的执行成果并协助制定和验证 衡量PRI3SM项目执行成果的数据收集工具；执行情况， 实际环境中基于证据的PRI3SM干预措施的监测和评价；关键的识别 实施PRI3SM干预措施的障碍和促进者；组织准备情况评估 实施PRI3SM项目并支持实施科学的质量测量 成果和建设，如可接受性、可行性、障碍和促进者以及组织准备情况。 目标2：为现有本地IS培训计划的实习生和初级调查人员提供 实施科学概念在现实世界中的应用机会。实施 Science Core将在以下领域提供实习和奖学金安排以及有指导的体验培训 面向初级研究人员的实现科学，如硕士和博士生以及 现有的实施科学培训计划。实施科学核心将利用 PRI3SM的能力建设方案，以在马拉维北卡罗来纳大学项目中全面建立执行科学股 为实施、科学、培训和资源提供持续支持。正在进行的支持将包括 与学员举行正式会议和一系列研讨会，以提供一个交流技能和 经验，关于项目和相关实施科学主题的陈述，以及对手稿的审查。