Implementation Science Core [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]

实施科学核心-摘要 为消除母婴传播，已经制定和测试了许多干预措施， 这些干预措施在现实世界中的转化和实施仍然有限。 实施科学提供了必要的工具，以确保干预措施得到良好实施， 它们在现实世界中的影响是实现的。实施科学核心的目标是提供 科学支持PRI 3SM的每个实施科学研究项目，以确保最新的 实施科学的原则和方法得到适当应用， 通过以下目标开展研究项目： 目标1。提供支持和资源，使马拉维项目的调查人员能够有效地 实施循证的消除母婴传播干预措施。执行科学核心将提供援助 以实施科学研究设计的选择和应用来指导协议的制定; 确定、选择和调整实施战略，以促进PRI 3SM的实施 项目;选择适当的执行成果并协助制定和验证 用于衡量PRI 3SM项目执行成果的数据收集工具; 监测和评价真实世界环境中基于证据的PRI 3SM干预措施;确定关键 实施PRI 3SM干预措施的障碍和促进因素; PRI 3SM项目的实施和支持实施科学的定性测量 结果和结构，如可接受性，可行性，障碍和促进者和组织准备。 目标2：为当地现有IS培训项目的受训人员和初级研究人员提供 在现实世界中应用实施科学概念的机会。执行 科学核心将提供实习和奖学金安置和指导的经验培训， 实施科学为初级研究人员，如硕士和博士生和毕业生， 现有的科学培训计划。实施科学核心将利用 PRI 3SM的能力建设计划，以充分建立马拉维项目的实施科学单位 在执行科学培训和资源方面提供持续支持。持续的支持将包括 与受训人员举行正式会议和一系列研讨会，为交流技能和 经验、项目介绍和相关的实施科学专题，以及审查手稿。

Implementation Science Core – Summary Many interventions have been developed and tested for elimination of mother-to-child transmission but the translation and implementation of these interventions into real-world settings has remained limited. Implementation science provides the necessary tools to ensure that interventions are implemented well and their impact in real-world settings is realized. The goal of the implementation science core is to provide scientific support to each of the PRI3SM implementation science research projects to ensure the latest principles and approaches in implementation science are applied appropriately to maximize the impact of the research projects through the following aims: Aim 1. To provide support and resources to enable investigators at UNC Project Malawi to effectively implement evidence-based EMTCT interventions. The implementation science core will provide assistance with selection and application of implementation science study designs to guide protocol development; identification, selection, and adaptation of implementation strategies to facilitate implementation of PRI3SM projects; selection of appropriate implementation outcomes and assistance in the development and validation of data collection tools for measuring implementation outcomes of the PRI3SM projects; implementation, monitoring and evaluation of evidence-based PRI3SM interventions in real-world settings; identification of key barriers and facilitators to implementing PRI3SM interventions; organizational readiness assessments for implementation of the PRI3SM projects and supporting qualitative measurement of implementation science outcomes and construct such as acceptability, feasibility, barriers and facilitators and organizational readiness. Aim 2: To provide trainees and junior investigators from existing local IS training programs with opportunities for real-world application of implementation science concepts. The Implementation Science Core will provide internship and fellowship placements and mentored experiential training in implementation science for junior investigators such as master’s and PhD students and graduates from existing implementation science training programs. The Implementation Science Core will leverage the capacity building program for PRI3SM to fully establish an Implementation Science Unit at UNC Project Malawi for ongoing support with implementation science training and resources. The ongoing support will include formal meetings and a seminar series with trainees to provide a platform for exchange of skills and experiences, presentations on projects and relevant implementation science topics, and review of manuscripts.