Implementation Science Core [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]

实施科学核心——总结 为了消除母婴传播，已经制定并测试了许多干预措施，但 这些干预措施在现实世界中的转化和实施仍然有限。 实施科学提供了必要的工具，以确保干预措施得到良好实施 它们对现实世界环境的影响已经实现。实施科学核心的目标是提供 为每个 PRI3SM 实施的科学研究项目提供科学支持，以确保最新的成果 适当应用实施科学的原则和方法，以最大限度地发挥实施科学的影响 研究项目通过以下目标： 目标 1. 提供支持和资源，使北卡罗来纳大学马拉维项目的调查人员能够有效地 实施循证 EMTCT 干预措施。实施科学核心将提供帮助 选择和应用实施科学研究设计来指导方案开发； 识别、选择和调整实施策略以促进 PRI3SM 的实施 项目；选择适当的实施结果并协助开发和验证 用于衡量 PRI3SM 项目实施成果的数据收集工具；实施， 在现实环境中监测和评估基于证据的 PRI3SM 干预措施；钥匙识别 实施 PRI3SM 干预措施的障碍和促进因素；组织准备度评估 实施 PRI3SM 项目并支持实施科学的定性衡量 结果和结构，例如可接受性、可行性、障碍和促进因素以及组织准备情况。 目标 2：为现有当地 IS 培训项目的学员和初级调查员提供 在现实世界中应用实施科学概念的机会。实施 科学核心将提供实习和奖学金安置以及指导体验式培训 为初级研究人员（如硕士生、博士生和毕业生）实施科学 现有实施科学培训计划。实施科学核心将利用 PRI3SM 的能力建设计划，旨在在北卡罗来纳大学马拉维项目中全面建立实施科学单位 持续支持实施科学培训和资源。持续的支持将包括 与受训人员举行正式会议和系列研讨会，为技能和技能交流提供平台 经验、项目演示和相关实施科学主题以及手稿审查。

Implementation Science Core – Summary Many interventions have been developed and tested for elimination of mother-to-child transmission but the translation and implementation of these interventions into real-world settings has remained limited. Implementation science provides the necessary tools to ensure that interventions are implemented well and their impact in real-world settings is realized. The goal of the implementation science core is to provide scientific support to each of the PRI3SM implementation science research projects to ensure the latest principles and approaches in implementation science are applied appropriately to maximize the impact of the research projects through the following aims: Aim 1. To provide support and resources to enable investigators at UNC Project Malawi to effectively implement evidence-based EMTCT interventions. The implementation science core will provide assistance with selection and application of implementation science study designs to guide protocol development; identification, selection, and adaptation of implementation strategies to facilitate implementation of PRI3SM projects; selection of appropriate implementation outcomes and assistance in the development and validation of data collection tools for measuring implementation outcomes of the PRI3SM projects; implementation, monitoring and evaluation of evidence-based PRI3SM interventions in real-world settings; identification of key barriers and facilitators to implementing PRI3SM interventions; organizational readiness assessments for implementation of the PRI3SM projects and supporting qualitative measurement of implementation science outcomes and construct such as acceptability, feasibility, barriers and facilitators and organizational readiness. Aim 2: To provide trainees and junior investigators from existing local IS training programs with opportunities for real-world application of implementation science concepts. The Implementation Science Core will provide internship and fellowship placements and mentored experiential training in implementation science for junior investigators such as master’s and PhD students and graduates from existing implementation science training programs. The Implementation Science Core will leverage the capacity building program for PRI3SM to fully establish an Implementation Science Unit at UNC Project Malawi for ongoing support with implementation science training and resources. The ongoing support will include formal meetings and a seminar series with trainees to provide a platform for exchange of skills and experiences, presentations on projects and relevant implementation science topics, and review of manuscripts.