SCH: A personalized wearable rehabilitation sensing system for stroke survivors

在美国，每年约有80万人患有中风，与之相关的 每年的成本约为330亿美元。中风也是导致残疾的主要原因，大多数中风幸存者都表现出 尽管中风后进行了广泛的康复，但仍存在持续性运动障碍。因此，独立生活 而在大多数中风幸存者中，重返劳动力大军是有限的。大多数中风幸存者都表现出 上肢和下肢运动障碍，从无法接触和抓住物体到受限 走动。尽管在临床上进行了广泛的康复治疗，但这些持续性的损害仍然严重。 限制独立生活，部分原因是临床环境下的训练效果没有有效地转移 到日常生活活动(ADL)。此外，慢性病患者无法执行必要的日常功能 由于肢体的废弃和/或神经肌肉的不适应，阶段可进一步加重损害。 系统。我们假设融入社区生活的持续康复训练(例如， 在家中、在商场或在公园)可以充分发挥诊所的康复效果，并每天提高 卒中幸存者的功能。 该项目的目标是开发一种基于社区的个性化康复传感系统，以 改善这些人的日常功能。因此，我们的提案直接涉及NICHD的科学 研究主题5：为残疾人提供安全有效的治疗和设备。我们 寻求一种真正可穿戴的系统，该系统佩戴舒适、运行时功耗低、使用友好(例如， 通过智能手机)。该系统将包括三个基本组成部分：基于纳米材料的多式联运系统 可穿戴式传感器网络，用于监控手臂和腿部的功能活动；低功耗数据采集， 处理和传输协议；以及智能手机应用程序，用于将培训结果传达给 用户和临床医生通过互联网并收到他们的反馈。具体地说，我们提出了以下目标。 目标1：开发真正可穿戴的传感器网络，可以监控涉及患者的身体活动 以及中风幸存者的对侧肢体。目标2：将多通道感知网络集成到 一致的系统和高效的传感器数据通信。目标3：从数据库中提取显著特征 获取运动活动信息，并提供个性化的社区康复指导。目标4：实现 评估系统性能和临床可行性。 相关性(请参阅说明)： 拟议的研究结果可能会改变中风幸存者的个性化康复 真正的可穿戴系统，可在各种社区环境中持续康复，使远程康复成为可能 康复，并最大限度地恢复中风幸存者的功能。可穿戴式身体活动跟踪 承诺实现医疗保健和福祉的范式转变。我们系统的用户友好性也可以 促进在其他有运动障碍的临床人群中广泛应用。

In the United States, there are about 800,000 people per year suffering a cerebral stroke, and the associated cost is about $33 billion per year. Stroke is also a leading cause of disability, and most stroke survivors exhibit persistent motor impairments despite extensive rehabilitation after the stroke. As a result, independent living and return to the work force is limited in a majority of stroke survivors. A majority of stroke survivors exhibit upper and lower limb motor impairments, ranging from incapability of reaching and grasping objects to limited ambulation. Despite extensive rehabilitation therapy in the clinic, these persistent impairments still severely limit independent living, partly because the training effect in the clinical setting is not effectively transferred to activities of daily living (ADL). Furthermore, the inability to perform essential daily functions at the chronic stage can further exacerbate the impairment, due to limb disuse and/or maladaptation of the neuromuscular system. We hypothesize that a continuous rehabilitation training that is integrated into community living (e.g., at home, in the shopping mall, or at the park) can capitalize the clinic rehabilitation effect and enhance daily functions of stroke survivors. The goal of this project is to develop a personalized community-based rehabilitation sensing system to improve daily functions of these individuals. Thus, our proposal directly addresses the NICHD scientific research theme 5: Advancing Safe and Effective Therapeutics and Devices for People with Disabilities. We seek a truly wearable system that is comfortable to wear, low power in operation, and friendly to use (e.g., via smartphones). The system will include three essential components: a nanomaterial-enabled multimodal wearable sensor network to monitor arm and leg functional activities; a low-power data acquisition, processing, and transmission protocol; and a smart phone APP to communicate training outcomes to the users and clinicians via internet and receive feedback from them. Specifically, we propose the following aims. Aim 1: To develop truly wearable sensor network that can monitor the physical activities involving the affected and contralateral limbs of stroke survivors. Aim 2: To integrate the multi-modality sensing network into a coherent system and efficiently communicate the sensor data. Aim 3: To extract prominent features from the acquired motor activity information and provide personalized community rehabilitation guidance. Aim 4: To evaluate the system performance and clinical feasibility. RELEVANCE (See instructions): The outcome of the proposed research could transform personalized rehabilitation of stroke survivors with a truly wearable system for continuous rehabilitation at various community settings, which could enable tele- rehabilitation, and maximize functional recovery of stroke survivors. Wearable physical activity tracking promises a paradigm shift for healthcare and wellbeing. The user-friendly nature of our system can also facilitate wide applications in other clinical populations with motor impairment.