Successful Aging in a Time of Wildfires

“野火时代的成功衰老”是一项研究，旨在研究 慢性和急性野火烟雾暴露对社区老年人成功老龄化的影响 居住在加利福尼亚州的成年人。自2000年以来，美国已经发生了超过140万起野火， 平均每年燃烧700万英亩。野火的排放构成了严重的威胁 对人类健康的影响，包括对心血管、呼吸和神经认知的影响，以及 据估计，每年造成15,000多人死亡。老年人尤其容易受到伤害 对野火排放的影响，野火排放加剧了呼吸系统和心脏病。 然而，除了对身体健康的直接影响外，目前还不清楚社会人口统计学如何 影响老年人接触野火烟雾的因素以及随后这种暴露是如何发生的 影响成功衰老的功能、认知和社会行为方面。AS 加州发生野火的风险特别高，这项研究将招募一名种族和 来自加利福尼亚州的1000名社区居住的老年人组成的种族多样化的纵向队列 并将分层社会生态模型应用于暴露在野火中的问题 废气排放会影响老年人的成功老龄化。这一战略反映了一种多学科的 研究人员对室外和室外环境中的毒素进行测量和建模的方法 收集和评估老年人外显体的表观遗传学变化；以及评估 社会、心理和行为因素，调节环境和生物 暴露因素及其对成功老化的影响。的广泛的长期目标 研究是为了确定那些可以预防、缓解或适应的因素，以便 居住在该国野火易感地区的老年人可以通过以下方式保障自己的健康 关心他们周围的空气，他们居住的建筑，以及他们的社会支持和 他们可以从事的保护性行为。研究性研究有四个具体研究 目标：(1)建立以加州为基地的不同水平老年人的观察队列 2002年至今的野火暴露量；(2)估计室外和室内化学暴露量- 队列参与者的显性野火排放；(3)分析唾液样本以确定 野火暴露的表观遗传标志及其与炎症的关系 对神经系统、心血管系统和呼吸系统的过程和功能影响；以及 (4)开发和测试暴露在空气中的老年人成功老龄化的生态模型 整合暴露和行为数据以确定关系的野火排放 野火烟雾暴露和成功的衰老结果之间的关系。

“Successful Aging in a Time of Wildfires” is a research study designed to examine the effects of chronic and acute wildfire smoke exposure on the successful aging of community-dwelling older adults living in California. Over 1.4 million wildfires have occurred in the U.S. since 2000, burning an average of 7 million acres annually. Emissions from wildfires pose significant threats to human health, including cardiovascular, respiratory, and neuro-cognitive effects, and are estimated to cause more than 15,000 fatalities per year. Older adults are particularly vulnerable to the impact of wildfire emissions, which exacerbate respiratory and cardiac diseases. However, beyond direct physical health effects it remains unclear how sociodemographic factors shape older adult exposure to wildfire smoke and how this exposure subsequently impacts the functional, cognitive, and socio-behavioral aspects of successful aging. As California is at particularly heightened risk of wildfires, this study will recruit a racially and ethnically diverse longitudinal cohort of 1,000 community-dwelling older adults from California and apply a hierarchical socio-ecological model to the question of whether exposure to wildfire emissions affects the successful aging of older adults. The strategy reflects a multidisciplinary approach in which the researchers measure and model ambient toxins in both outdoor and indoor air; collect and assess epigenetic changes in older adults’ exosomes; and evaluate the social, psychological, and behavioral factors that moderate the environmental and biological exposure factors and their impact on successful aging. The broad long-term objectives of the study are to identify those factors amenable to prevention, mitigation, or adaptation, so that older adults living in wildfire-susceptible regions of the country can safeguard their health by attending to the air around them, the buildings in which they live, and to the social supports and protective behaviors in which they can engage. The research study has four specific research aims: (1) to develop a California-based observational cohort of older adults with various levels of wildfire exposure from 2002-present; (2) to estimate outdoor and indoor exposure to chemically- explicit wildfire emissions among cohort participants; (3) to analyze saliva samples to identify epigenetic markers of wildfire-exposure, and analyze their association with inflammatory processes and functional impacts on neurological, cardiovascular, and respiratory systems; and (4) to develop and test an ecological model for successful aging in older adults exposed to wildfire emissions that integrates exposure and behavioral data to determine the relationship between wildfire smoke exposure and successful aging outcomes.