Successful Aging in a Time of Wildfires

野火时期的成功老龄化

• 批准号: 10688315
• 负责人: DAVID M ABRAMSON
• 金额: $ 68.08万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688315
• 关键词: Acute; Address; Affect; Aging; Air; Area; Behavior; Behavioral; Biological; Biological Markers; Burn injury; California; Carbon Monoxide; Cardiovascular system; Censuses; Chemicals; Chronic; Climatology; Cognitive; Communities; Country; Data; Disasters; Dose; Elderly; Enrollment; Epidemiology; Epigenetic Process; Ethnic Origin; Ethnic group; Exposure to; Fire - disasters; Frequencies; Geography; Gerontology; Health; Heart Diseases; Home; Human; Immune; Indoor Air Pollution; Indoor Air Quality; Inflammatory; Longitudinal cohort; Measures; Mediating; Messenger RNA; Meteorology; MicroRNAs; Modeling; Molecular; Molecular Profiling; Neurocognitive; Neurologic; Outcome; Ozone; Participant; Particulate Matter; Pathway interactions; Population; Population Density; Prevention; Process; Psychosocial Factor; Psychosocial Influences; Public Health; Race; Research; Research Design; Research Personnel; Respiratory Disease; Respiratory System; Risk; Saliva; Salivary; Sampling; Seasons; Series; Shapes; Small RNA; Smoke; Social Behavior; Social support; Socioeconomic Status; Sociology; Source; Subgroup; Surveys; Testing; Time; Toxin; Tracer; Travel; Wildfire; atmospheric sciences; base; biobank; biopsychosocial factor; coarse particles; cohort; design; epigenetic marker; ethnic diversity; exosome; fine particles; immune function; indoor air; indoor exposure; interdisciplinary approach; physical conditioning; pollutant; protective behavior; psychologic; racial diversity; recruit; research study; respiratory; response; saliva sample; social; sociodemographic factors; time use

“Successful Aging in a Time of Wildfires” is a research study designed to examine the effects of chronic and acute wildfire smoke exposure on the successful aging of community-dwelling older adults living in California. Over 1.4 million wildfires have occurred in the U.S. since 2000, burning an average of 7 million acres annually. Emissions from wildfires pose significant threats to human health, including cardiovascular, respiratory, and neuro-cognitive effects, and are estimated to cause more than 15,000 fatalities per year. Older adults are particularly vulnerable to the impact of wildfire emissions, which exacerbate respiratory and cardiac diseases. However, beyond direct physical health effects it remains unclear how sociodemographic factors shape older adult exposure to wildfire smoke and how this exposure subsequently impacts the functional, cognitive, and socio-behavioral aspects of successful aging. As California is at particularly heightened risk of wildfires, this study will recruit a racially and ethnically diverse longitudinal cohort of 1,000 community-dwelling older adults from California and apply a hierarchical socio-ecological model to the question of whether exposure to wildfire emissions affects the successful aging of older adults. The strategy reflects a multidisciplinary approach in which the researchers measure and model ambient toxins in both outdoor and indoor air; collect and assess epigenetic changes in older adults’ exosomes; and evaluate the social, psychological, and behavioral factors that moderate the environmental and biological exposure factors and their impact on successful aging. The broad long-term objectives of the study are to identify those factors amenable to prevention, mitigation, or adaptation, so that older adults living in wildfire-susceptible regions of the country can safeguard their health by attending to the air around them, the buildings in which they live, and to the social supports and protective behaviors in which they can engage. The research study has four specific research aims: (1) to develop a California-based observational cohort of older adults with various levels of wildfire exposure from 2002-present; (2) to estimate outdoor and indoor exposure to chemically- explicit wildfire emissions among cohort participants; (3) to analyze saliva samples to identify epigenetic markers of wildfire-exposure, and analyze their association with inflammatory processes and functional impacts on neurological, cardiovascular, and respiratory systems; and (4) to develop and test an ecological model for successful aging in older adults exposed to wildfire emissions that integrates exposure and behavioral data to determine the relationship between wildfire smoke exposure and successful aging outcomes.

“野火时期的成功衰老”是一项研究，旨在研究 慢性和急性野火烟雾暴露对社区老年人成功老龄化的影响 生活在加州的成年人。自2000年以来，美国发生了140多万起野火， 每年平均燃烧700万英亩的土地。野火排放物构成重大威胁 对人类健康的影响，包括心血管、呼吸和神经认知影响， 估计每年造成超过15，000人死亡。老年人特别容易受到伤害 野火排放物会加剧呼吸道和心脏疾病。 然而，除了直接的身体健康影响外，尚不清楚社会人口统计学 影响老年人暴露于野火烟雾的因素以及这种暴露如何随后 影响成功老龄化的功能，认知和社会行为方面。作为 加州的野火风险特别高，这项研究将招募一个种族和 来自加州的1，000名社区居住老年人的种族多样性纵向队列 并应用一个等级社会生态模型来研究暴露于野火是否 影响老年人的成功衰老。该战略反映了一个多学科的 研究人员测量和模拟室外和室外环境毒素的方法， 室内空气;收集和评估老年人外泌体的表观遗传变化;并评估 社会、心理和行为因素，调节环境和生物 暴露因素及其对成功老化的影响。的广泛的长期目标， 研究目的是确定那些可以预防、减轻或适应的因素， 生活在该国野火易发地区的老年人可以通过以下方式保护自己的健康： 关注他们周围的空气，他们居住的建筑物，以及社会支持， 保护性的行为。研究性学习有四个具体的研究 目的：（1）建立一个加利福尼亚州的老年人观察队列， 从2002年至今的野火暴露;（2）估计室外和室内暴露于化学- 队列参与者中明确的野火排放;（3）分析唾液样本，以确定 野火暴露的表观遗传标记，并分析其与炎症的关联 对神经、心血管和呼吸系统的过程和功能影响;以及 (4)开发和测试一个生态模型，用于暴露于以下环境中的老年人成功衰老： 野火排放，整合暴露和行为数据，以确定关系 野火烟雾暴露和成功的衰老结果之间的关系。