SARS-CoV-2 correlates of protection in a Latino-origin population

总结 这是一项支持SARS-CoV-2血清学、血清学网络的倡议。 这种病毒的快速传播和传播对医疗保健系统造成了重大影响， 严重的社会破坏。特别容易受到影响的是黑人和拉丁美洲裔人口。 除了人口统计学和社会环境外，遗传背景是否起作用还不得而知。 在这一结果中起主导作用。在42个州加上华盛顿特区，西班牙裔/拉丁裔占更大份额 比他们在人口中所占的比例还要高。在八个州，这个数字是四倍多。一个伟大 在全球范围内已经部署了大量的努力来控制、缓解和了解这种循环， 传播和免疫反应等SARS-CoV-2。然而，人们对 特别是在对这种病毒的免疫反应的动态中。另一个问题是， 抗体滴度和它们的中和能力之间的关系知之甚少。由于它，很难 预测具有针对SARS-CoV-2的特异性抗体的个体的保护水平。目前为止 大流行的度量、预测、预测模型等一直依赖于分子和血清学 以压倒性的方式进行分析。T细胞是免疫反应中的关键参与者， 提供咨询意见和指导的组织甚至没有提到这一点。 流行病 了解驱动血清学，体液和细胞免疫反应的机制， 宿主基因以及它们如何与SARS-CoV-2的保护相关是强制性的。落实 这个SeroNet项目在拉丁美洲-非洲背景的人群中确定SARS的真实的血清阳性率- 二型冠状病毒此外，我们的目标是研究遗传背景（HLA表征）对疾病的贡献 结果和对最差临床表现的易感性。为了实现我们的目标，我们将详细研究 抗体中和活性，T细胞免疫表型，细胞因子谱，并将这些数据与 基因特征。特殊脆弱人群（患有自身免疫性疾病等合并症的个体） 疾病、免疫抑制和肥胖、医疗服务不足和癌症人群）将纳入 的cohort）。我们的结果将与其他SARS-CoV-2血清组成员获得的结果进行比较。 网络

Summary This is an initiative in support of the SARS-CoV-2 Serological Sciences, Sero Network. The rapid circulation and spread of this virus lead to a significant impact to the healthcare systems with an important societal disruption. Particularly susceptible has been the Black and Latino American origin population. In addition to the demographic and social environment, it is no know if the genetic background plays a predominant role in that outcome. In 42 states plus Washington D.C., Hispanics/Latinos make up a greater share of confirmed cases than their share of the population. In eight states, it's more than four times greater. A great deal of effort has been deployed at a global level to contain, mitigate, and to understand the circulation, transmission, and immune response among others to SARS-CoV-2. However, there is a huge lack of knowledge particularly in the dynamic of the immune response to this virus. One additional problem is that the correlation between the antibodies titers and their neutralizing capabilities is poorly understood. Due to it, is difficult to anticipate the level of protection of an individual having specific antibodies against SARS-CoV-2. So far, the pandemic metrics, predictions, forecast models, and so on have been relying on molecular and serological assays in an overwhelming manner. The contribution of the T cells, a key player in the immune response has not been even mentioned by the organizations providing advice and guidance on the management of the pandemic. Understanding the mechanisms driving the serological, humoral, and cellular immune responses associated with the host genetic and how they correlate with protection against SARS-CoV-2 is mandatory. We will implement this SeroNet project in a Latino-African background population to determine the real seroprevalence to SARS- CoV-2. Also, we aim to study the contribution of the genetic background (HLA characterization) to the disease outcome and as susceptibility to worst clinical presentations. I order to accomplish our goals we will look in detail to the antibodies neutralizing activity, T cells immunophenotypes, cytokine profile and will integrate that data with the genetic characterization. Particular vulnerable population (individuals with comorbidities such as autoimmune disease, immunosuppression, and obesity, medically underserved, and cancer populations) will be included in the cohort). Our results will be compared with results obtained by other group members of the SARS-CoV-2 Sero Network.