New Cures from Old Medicines - Targeting abnormal metabolism in Alzheimer's Disease
New Cures from Old Medicines - Targeting abnormal metabolism in Alzheimer's Disease
批准号:
10688800
负责人:
Madhav Thambisetty
金额:
$14.52万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Alzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAsthmaBig DataBiochemical PathwayBiological AssayBloodBrainCOVID-19 pandemicCell Culture TechniquesDataData AnalysesData SetDreamsDrug PrescriptionsExposure toFDA approvedFatty AcidsGlucoseGrantIndividualMedicareMedicineMetabolismPathway interactionsPatientsPharmaceutical PreparationsPhospholipid MetabolismRandomized Clinical TrialsResearchRheumatoid ArthritisServicesSignal TransductionTestingValidationbaseclinical practicecostdrug candidatedrug repurposingdrug testingexperimental studyhealth recordmolecular phenotypenovel therapeuticsprotective effectsound
中文摘要
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英文摘要
The DREAM study began on 9/16/2019. 10 drugs have been tested for their ability to lower the risk of Alzheimer's disease and related dementias (ADRD). These drugs are commonly used to treat rheumatoid arthritis. Encouraging results from one of the drugs tested are being confirmed through parallel validation experiments in cell culture based assays. The next set of analyses will test commonly used anti-asthma drugs. Due to delays arising from the COVID-19 pandemic, a no-cost extension of 9-months has been granted to allow for the completion of proposed analyses of 20 candidate drugs.
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New Cures from Old Medicines - Targeting abnormal metabolism in AD
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批准号:10019244
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项目类别:
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资助金额:$10.82万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:10688757
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项目类别:
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资助金额:$18.99万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:10250845
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项目类别:
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资助金额:$296.2万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:9351926
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项目类别:
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资助金额:$89.46万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:8931483
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项目类别:
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资助金额:$41.62万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
New Cures from Old Medicines - Targeting abnormal metabolism in AD
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批准号:10250862
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项目类别:
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资助金额:$21.16万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:8736492
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项目类别:
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资助金额:$50.75万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:9147243
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项目类别:
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资助金额:$108.44万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
New Cures from Old Medicines - Targeting abnormal metabolism in Alzheimer's Disease
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批准号:10913062
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项目类别:
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资助金额:$21.17万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:9549255
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项目类别:
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资助金额:$194.71万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:10913017
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项目类别:
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资助金额:$26.05万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Predictive Blood and Cerebrospinal Fluid Metabolomic Markers in Alzheimers Disease
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批准号:9549304
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项目类别:
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资助金额:$70.1万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Experimental validation of candidate AD treatments identified by multi-OMICS analyses and real-world clinical evidence
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批准号:10914575
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项目类别:
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资助金额:$1.63万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease
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批准号:10019242
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项目类别:
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资助金额:$113.6万
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财政年份:--
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负责人:Madhav Thambisetty
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依托单位:
国内基金
海外基金
新型F-18标记香豆素衍生物PET探针的研制及靶向Alzheimer's Disease 斑块显像研究
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批准号:81000622
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项目类别:青年科学基金项目
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资助金额:20.0万元
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批准年份:2010
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负责人:梁胜
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依托单位:
阿尔茨海默病(Alzheimer's disease,AD)动物模型构建的分子机理研究
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批准号:31060293
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项目类别:地区科学基金项目
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资助金额:26.0万元
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批准年份:2010
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负责人:郭亚芬
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依托单位:
跨膜转运蛋白21(TMP21)对引起阿尔茨海默病(Alzheimer'S Disease)的γ分泌酶的作用研究
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批准号:30960334
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项目类别:地区科学基金项目
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资助金额:22.0万元
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批准年份:2009
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负责人:董贵成
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依托单位: