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中文摘要
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项目摘要--行政/计划充实核心 圣地亚哥Nathan Shock行政/计划充实核心(ADMIN CORE)的总体目标 中心(SD-NCS)旨在促进和促进对衰老基本机制的研究,重点是 关于揭示老化过程中的异质性。管理核心将作为以下项目的中心联络点 所有SD-NCS活动,维护SD-NSC核心之间以及SD-NSC核心之间的通信线路 NSC和外部咨询小组、其他内森休克中心(包括内森休克中心 协调中心(NSC3)、外部研究社区和其他区域研究中心。这个 管理核心将提供三个关键功能。首先,行政核心将监督三项研究的活动 资源核心,即老龄化核心的人类细胞模型、老龄化核心的异质性和 老龄化核心一体化模式,确保为调查人员提供优质高效的服务 进行衰老研究。这将包括业务和财务监督。管理核心将提供帮助 协调核心之间的数据和资源流动(工作流优化),以及 向研究实验室传播数据和资源。管理核心将执行常规质量控制 评估、监控研究社区采用核心服务的情况,并平衡对核心服务的需求 具有工作流能力的服务。最后,行政核心将协调外部咨询小组的工作 并落实小组建议,以改善核心服务。第二,管理核心将促进努力 研究发展核心推出新的老龄化研究项目和促进教师发展 和训练。行政核心将协调努力,以建立和保持强劲的职业发展 老年调查员方案,重点是初级调查员和资深调查员 进入老龄化研究领域。管理核心将帮助运营一项试点拨款计划,运营培训后勤 研讨会,并促进导师计划。将监测这些计划的有效性,并 由管理核心进行评估,并根据管理人员的投入对这些活动进行调整 委员会和外部咨询小组。第三,行政核心将组织和监督以下方面的外联活动 SD-NSC。这将包括建立和维护一个网站来宣传SD-NSC核心服务和 NSC成就;与NSC3、其他NSC、三个SD-NSC参与的广泛接口 机构和其他区域研究中心促进合作;与索尔克合作 通讯办公室宣传SD-NSC的成就;组织讲座、研讨会、播客、 以及社区活动,广泛传播老龄化研究的重要性。最后,要实现这些目标 任务,管理核心将提供项目管理服务,以确保SD-NSC设置的三个阶段- 按时完成上线、上线和运行,实现可交付成果。这将包括收款 与所有SD-NSC活动相关的可量化指标,以衡量与NSC3合作的成功。
英文摘要
PROJECT SUMMARY – Administrative/Program Enrichment Core The overall goal of the Administrative/Program Enrichment Core (Admin Core) of the San Diego Nathan Shock Center (SD-NCS) is to facilitate and promote research into the basic mechanisms of aging, with an emphasis on revealing heterogeneities in the aging process. The Admin Core will serve as the central point of contact for all SD-NCS activities, maintaining lines of communication between SD-NSC Cores, as well as between SD- NSC and the External Advisory Panel, other Nathan Shock Centers (including the Nathan Shock Centers Coordinating Center (NSC3)), the external research community, and other regional research Centers. The Admin Core will serve three key functions. First, the Admin Core will oversee activities of the three Research Resource Cores, namely the Human Cell Models of Aging Core, the Heterogeneity of Aging Core, and the Integrative Models of Aging Core, to ensure that high quality and efficient services are provided to investigators performing aging research. This will include both operational and financial oversight. The Admin Core will help to coordinate the flow of data and resources between Cores (workflow optimization), as well as the dissemination of data and resources to research labs. The Admin Core will perform regular quality control assessments, monitor the uptake of Core services by the research community, and balance demand for Core services with workflow capacity. Finally, the Admin Core will coordinate efforts of an External Advisory Panel and implement panel recommendations to improve Core services. Second, the Admin Core will facilitate efforts of the Research Development Core to launch new aging research projects and to promote faculty development and training. The Admin Core will coordinate efforts to establish and maintain a robust career development program for aging investigators, with an emphasis on junior investigators and established investigators entering the aging research field. The Admin Core will help run a pilot grant program, run logistics for training workshops, and facilitate a mentorship program. Effectiveness of these programs will be monitored and evaluated by the Admin Core, and adjustments made to these activities based on input from the Executive Committee and External Advisory Panel. Third, the Admin Core will organize and oversee outreach activities of the SD-NSC. This will include establishing and maintaining a website to advertise SD-NSC Core services and NSC accomplishment; interfacing extensively with NSC3, other NSCs, the three SD-NSC participating Institutions, and other regional research Centers to foster collaborations; working with the Salk Communications Office to publicize SD-NSC accomplishments; and organizing lectures, symposia, podcasts, and community events to widely broadcast the importance of aging research. Finally, to accomplish these tasks, the Admin Core will provide project management services to ensure the three Phases of SD-NSC set- up, launch, and operation are completed on time and that deliverables are achieved. This will include collection of quantifiable metrics relevant to all SD-NSC activities to measure success in collaboration with NSC3.
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Project 1: The role of mitochondrial stress in liver aging and cancer progression and intervention via oxidative mitohormesis
Project 1: The role of mitochondrial stress in liver aging and cancer progression and intervention via oxidative mitohormesis
San Diego Nathan Shock Center
Diversity Candidate Research Supplement to Study Human Cell Models of Aging
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