Noncanonical functions of the ribosome in response to cellular stress

我的实验室广泛地研究了核糖体在决定细胞 命运的决定一些工作在2020年底实验室启动后不久就开始了， 实验室空间已经建成，并雇用了该科的成员。实验室的研究 专注于核糖体如何感知和响应由细胞或 环境胁迫条件，如营养饥饿、缺氧和紫外线照射。 细胞应激影响核糖体如何沿着mRNA模板沿着移动，因此改变了mRNA的表达。 翻译景观，并最终改变细胞的基因表达程序。一 更好地理解应激条件下的翻译调节机制， 因此对于克服人类健康面临的挑战至关重要。我们已经开始破译 RNA损伤诱导细胞死亡的分子机制。我们将纳米孔RNA直接 测序技术，以监测由细胞和 环境压力，我们目前正在开发计算方法来分析 来自应激细胞的纳米孔测序数据。

My laboratory broadly investigates the function of the ribosome in determining cell fate decisions. Some work began soon after the launch of the lab in late 2020, the setup of the laboratory space was accomplished, and section members were hired. Research in the lab has focused on how ribosomes sense and respond to translational distress induced by cellular or environmental stress conditions, such as nutrient starvation, hypoxia, and UV irradiation. Cellular stress influences how ribosomes move along the mRNA templates, therefore changing the translational landscape and ultimately altering the gene expression programs of the cell. A better understanding of the mechanism of translational regulation under stress conditions is therefore essential for overcoming challenges to human health. We have begun deciphering the molecular mechanisms of cell death induced by damaged RNA. We have adapted Nanopore RNA direct sequencing technology to monitor RNA damage and modification caused by cellular and environmental stress, and we are currently developing computational methods for analyzing Nanopore sequencing data from stressed cells.