Structural biology of host-pathogen interactions

宿主-病原体相互作用的结构生物学

• 批准号: 10702833
• 负责人: Susan Lea
• 金额: $ 125.13万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10702833
• 关键词: Antibiotics; Bacteria; Bacteriophages; Cryoelectron Microscopy; Disease; Environment; Future; Goals; Health; Human; Infection; Medical; Methods; Molecular; Multiprotein Complexes; Pathogenesis; Pathway interactions; Play; Protein Secretion; Proteins; Research; Resistance; Role; System; Work; X-Ray Crystallography; cell motility; genetic information; human pathogen; novel; pathogen; structural biology; uptake

We are studying Bacterial systems required for pathogenesis, chiefly secretion and motility systems. These two functions are often achieved via a single large apparatus such as in the bacterial flagellar system which is also a protein secretion system. We are using structural biology and functional studies to dissect systems relevant for infection by a variety of human pathogens. Another range of systems we are starting to investigate include protein assemblies associated with uptake of genetic information from the environment and resistance to phages

我们正在研究发病机理所需的细菌系统，主要是分泌和运动系统。这两个功能通常是通过单个大型设备（例如细菌鞭毛系统中）实现的，这也是蛋白质分泌系统。我们正在使用结构生物学和功能研究来解剖各种人类病原体与感染相关的系统。我们开始研究的另一个系统包括与来自环境的遗传信息相关的蛋白质组件以及对噬菌体的抗性