MAPPING OF PROTEIN-PROTEIN INTERACTIONS IN THE CD40 PATHWAY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类的免疫系统为传染病和恶性疾病提供了屏障。然而，免疫细胞的不适当激活可能会导致类风湿性关节炎、系统性红斑狼疮和多发性硬化症等疾病。此外，改变免疫细胞生长调节的突变可能导致各种形式的白血病和淋巴瘤。 CD40是免疫细胞激活和生长的关键蛋白之一。CD40表达于多种类型的免疫细胞表面，在B细胞的激活过程中尤为重要。B细胞是免疫系统中唯一产生抗体的细胞，通常需要通过CD40刺激才能获得最佳激活。CD40还可以为包括恶性B细胞在内的各种类型的癌细胞提供生存信号。CD40的尾巴固定在B细胞膜上，延伸到细胞内部，在那里它与信号蛋白相互作用。组成CD40信号通路的细胞内分子只有部分特征，我们的目标是确定剩余的成分。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The human immune system provides barriers to infectious disease and malignancy. However, inappropriate activation of immune cells can result in diseases like rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. In addition, mutations that alter growth regulation in immune cells can lead to various forms of leukemia and lymphoma. One of the key proteins in the activation and growth of immune cells is CD40. CD40 is expressed on the surfaces of several types of immune cells, and is particularly important in the activation of B cells. B cells are the only antibody producing cells in the immune system and usually require stimulation through CD40 for optimal activation. CD40 may also provide viability signals for various types of cancer cells, including malignant B cells. Anchored in the B cell membrane, the tail of CD40 extends into the interior of the cell where it interacts with signaling proteins. The intracellular molecules comprising the CD40 signaling pathway are only partially characterized and it is our goal to identify the remaining components.