MAPPING OF PROTEIN-PROTEIN INTERACTIONS IN THE CD40 PATHWAY

CD40 通路中蛋白质-蛋白质相互作用的图谱

• 批准号: 7359137
• 负责人: BRUCE S HOSTAGER
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7359137
• 关键词: MAPPING; PROTEIN; INTERACTIONS; CD40; PATHWAY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The human immune system provides barriers to infectious disease and malignancy. However, inappropriate activation of immune cells can result in diseases like rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. In addition, mutations that alter growth regulation in immune cells can lead to various forms of leukemia and lymphoma. One of the key proteins in the activation and growth of immune cells is CD40. CD40 is expressed on the surfaces of several types of immune cells, and is particularly important in the activation of B cells. B cells are the only antibody producing cells in the immune system and usually require stimulation through CD40 for optimal activation. CD40 may also provide viability signals for various types of cancer cells, including malignant B cells. Anchored in the B cell membrane, the tail of CD40 extends into the interior of the cell where it interacts with signaling proteins. The intracellular molecules comprising the CD40 signaling pathway are only partially characterized and it is our goal to identify the remaining components.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。人类免疫系统为传染病和恶性肿瘤提供了屏障。然而，免疫细胞的不适当激活可导致疾病，如类风湿性关节炎，系统性红斑狼疮和多发性硬化症。此外，改变免疫细胞生长调节的突变可导致各种形式的白血病和淋巴瘤。CD 40是免疫细胞激活和生长的关键蛋白质之一。CD 40在几种类型的免疫细胞的表面上表达，并且在B细胞的活化中特别重要。B细胞是免疫系统中唯一产生抗体的细胞，通常需要通过CD 40刺激以获得最佳活化。CD 40还可以为各种类型的癌细胞（包括恶性B细胞）提供活力信号。锚定在B细胞膜中，CD 40的尾部延伸到细胞内部，在那里它与信号蛋白相互作用。构成CD 40信号通路的细胞内分子仅得到部分表征，我们的目标是识别其余成分。