Investigating the effect of oral microbiome on cognition in HIV-infected chronic cannabis users
研究口腔微生物组对感染艾滋病毒的长期大麻使用者认知的影响
基本信息
- 批准号:10708001
- 负责人:
- 金额:$ 71.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-30 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationActinomycesActinomyces odontolyticusAgeAlzheimer&aposs DiseaseAmyloid beta-42Amyloid beta-ProteinAnti-Bacterial AgentsAnti-Retroviral AgentsBacteriaBacterial AntigensBehavioralBiological ProcessBloodBrainCannabisCardiovascular DiseasesCentral Nervous SystemChronicClinicalCocaine UsersCognitionCognitive deficitsDataDental HygieneDepositionDiseaseDoseDrug usageEndocannabinoidsFecesFrequenciesGenetic TranscriptionGoalsHIVHIV InfectionsHIV-associated neurocognitive disorderHumanImmuneImpaired cognitionIn VitroIndividualInfiltrationInflammatoryInflammatory ResponseLinkLong-Term EffectsMacrophageMediatingMemoryMemory LossMemory impairmentModelingMolecularMorbidity - disease rateMusMyeloid CellsNeurocognitionNeurocognitiveNeuropathogenesisOralOral cavityPathogenesisPathway interactionsPatientsPeptidesPeptidoglycanPerformancePersonsPharmaceutical PreparationsPlasmaPlayPremature BirthProbioticsProductionProspective cohortProteinsRegulationReportingRoleSalivaSignal PathwaySmokerTHC exposureTLR2 geneTherapeuticTimeTransgenic MiceTransgenic OrganismsVirus DiseasesWorkantiretroviral therapybacteriomecell free DNAcell motilitycognitive enhancementcognitive functioncognitive performancecomparison controlcytokineimmune functionin vivoin vivo Modelinhibitormarijuana smokermarijuana usemarijuana usermemory recognitionmicrobiomemortalitymouse modelmycobiomeneuroAIDSneuropathologyneurotoxicitynoveloral bacteriaoral microbiomepre-clinicaltobacco smokerstranscription factor
项目摘要
Project Summary
In the context of human immunodeficiency virus (HIV) infection, cannabis use is an important topic and is the
most commonly used drug among HIV-infected individuals. Positive and negative effects of cannabis use in the
context of HIV have been reported for various biological processes, including cognitive performance and immune
function. Reports vary from cannabis enhancing cognitive function to causing synergistic decline in cognition.
Thus, the exact role and limits of chronic cannabis use on HIV cognition under immune perturbations remain
unclear. The aim of the present study is to investigate the effects of cannabis-associated oral microbiome on
neurocognitive performance in HIV disease by focusing on clinical (Aim 1) and preclinical (Aim 2) neuroHIV
models. We and other colleagues have found that Actinomyces species bacteria (e.g. A. meyeri and A.
odontolyticus) in the oral cavity of humans, are enriched in the saliva from chronic cannabis users compared to
non-users and A. meyeri is enriched in HIV-infected individuals compared to uninfected individuals. But oral A.
species enrichment was not demonstrable in tabacco smokers or chronic cocaine users. Further, oral enrichment
of A. meyeri was associated with younger age of first cannabis use. Here, we aim to investigate if A. species
bacteria has a significant role in HIV neuropathogenesis. To achieve this goal, in Specific Aim 1, HIV cannabis
users will be assessed to determine the link between cannabis use-associated oral microbiome (i.e., enrichment
of A. meyeri) and cognitive performance by focusing on 1) saliva bacteriome and mycobiome and plasma
translocation of A. species bacterial antigens; 2) molecular mechanisms of A. species bacteria mediated TLR2
signaling pathway activation in myeloid cells; 3) neurocognitive performance and its association with microbiome.
Specific Aim 2 will make use of two well-established transgenic (tg) mouse models of neuroHIV, including the
HIV Tg26 tg and the HIV Tat tg mice, to allow us to determine: 1) the chronic effects of THC and CBD exposure
on neurocognition and neuropathology; 2) the chronic effects of THC and CBD exposure on enrichment of A.
species bacteria and myeloid cell infiltration to the brain under antiretroviral (ART) drugs; and 3) the mechanisms
of cannabis-associated A. meyeri bacteria on neurocognition, neuropathology, and endocannabinoid levels.
Understanding the role of chronic cannabis use on oral microbiome and it’s effects on neurocognitive
performance in HIV disease is critical to determine its therapeutic benefits and limits in the treatment of patients
with accelerated central nervous system pathogenesis under traditional combination antiretroviral therapy
(cART).
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sylvia Fitting其他文献
Sylvia Fitting的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sylvia Fitting', 18)}}的其他基金
In vivo calcium imaging during appetitive learning in HIV Tat transgenic mice exposed to cannabis
暴露于大麻的 HIV Tat 转基因小鼠食欲学习过程中的体内钙成像
- 批准号:
10696442 - 财政年份:2023
- 资助金额:
$ 71.57万 - 项目类别:
Investigating the effect of oral microbiome on cognition in HIV-infected chronic cannabis users
研究口腔微生物组对感染艾滋病毒的长期大麻使用者认知的影响
- 批准号:
10483586 - 财政年份:2022
- 资助金额:
$ 71.57万 - 项目类别:
Endocannabinoid-mediated neuroprotection in models of neuroAIDS in vivo
体内神经艾滋病模型中内源性大麻素介导的神经保护
- 批准号:
10394213 - 财政年份:2018
- 资助金额:
$ 71.57万 - 项目类别:
Endocannabinoid-mediated neuroprotection in models of neuroAIDS in vivo
体内神经艾滋病模型中内源性大麻素介导的神经保护
- 批准号:
9906196 - 财政年份:2018
- 资助金额:
$ 71.57万 - 项目类别:
Investigation of endocannabinoid-mediated neuroprotection in models of neuroAIDS
神经艾滋病模型中内源性大麻素介导的神经保护作用的研究
- 批准号:
9135623 - 财政年份:2016
- 资助金额:
$ 71.57万 - 项目类别:
Opiate drug abuse & HIV-induced excitotoxicity in striatal neurons
阿片类药物滥用
- 批准号:
9064737 - 财政年份:2015
- 资助金额:
$ 71.57万 - 项目类别:
Opiate drug abuse & HIV-induced excitotoxicity in striatal neurons
阿片类药物滥用
- 批准号:
8964511 - 财政年份:2015
- 资助金额:
$ 71.57万 - 项目类别:
Opiate drug abuse & HIV-induced excitotoxicity in striatal neurons
阿片类药物滥用
- 批准号:
8410974 - 财政年份:2012
- 资助金额:
$ 71.57万 - 项目类别:
Opiate drug abuse & HIV-induced excitotoxicity in striatal neurons
阿片类药物滥用
- 批准号:
8586520 - 财政年份:2012
- 资助金额:
$ 71.57万 - 项目类别:
相似海外基金
Development of anti-scirrhous stomach cancer produced by the deep-sea actinomyces
深海放线菌抗硬胃癌的开发
- 批准号:
21H03007 - 财政年份:2021
- 资助金额:
$ 71.57万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Comprehensive analysis of the fluoride-effects on the metabolic mechanism of oral Actinomyces
氟对口腔放线菌代谢机制影响的综合分析
- 批准号:
16K20447 - 财政年份:2016
- 资助金额:
$ 71.57万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Breakthrough of fluoride-functional mechanism and establishment of its utilization for oral Actinomyces
氟作用机制的突破及其在口腔放线菌中的应用
- 批准号:
25861783 - 财政年份:2013
- 资助金额:
$ 71.57万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
The role of the initial colonizer Actinomyces oris in dental plaque formation.
初始定殖者口放线菌在牙菌斑形成中的作用。
- 批准号:
24592790 - 财政年份:2012
- 资助金额:
$ 71.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Genome sequencing and mutational analysis of the Actinomyces strains with enhanced biofilm phenotype
具有增强生物膜表型的放线菌菌株的基因组测序和突变分析
- 批准号:
23792118 - 财政年份:2011
- 资助金额:
$ 71.57万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Molecular Assembly on the Cell Surface of Actinomyces
放线菌细胞表面的分子组装
- 批准号:
8774895 - 财政年份:2008
- 资助金额:
$ 71.57万 - 项目类别:
Molecular Assembly on the Cell Surface of Actinomyces
放线菌细胞表面的分子组装
- 批准号:
10455056 - 财政年份:2008
- 资助金额:
$ 71.57万 - 项目类别:
Molecular Assembly on the Cell Surface of Actinomyces
放线菌细胞表面的分子组装
- 批准号:
8588304 - 财政年份:2008
- 资助金额:
$ 71.57万 - 项目类别:
Molecular Assembly on the Cell Surface of Actinomyces
放线菌细胞表面的分子组装
- 批准号:
7783826 - 财政年份:2008
- 资助金额:
$ 71.57万 - 项目类别:
Molecular Assembly on the Cell Surface of Actinomyces
放线菌细胞表面的分子组装
- 批准号:
7373000 - 财政年份:2008
- 资助金额:
$ 71.57万 - 项目类别: