Administrative Core

行政核心

• 批准号: 10708052
• 负责人: Silvia C. Formenti
• 金额: $ 34.33万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708052
• 关键词: Achievement; Adjuvant Radiotherapy; Adverse event; Advocate; Age; Award; Charge; Clinical Trials; Collaborations; Colorectal; Communication; Data; Data Analyses; Data Element; Data Scientist; Descriptor; Discipline; Electronic Mail; Ensure; Equilibrium; Ethics; Europe; Evaluation; Feedback; Funding; Future; Gender; Generations; Grant; Image; Immune; Immune response; Immune system; Immunity; Immunology; Immunooncology; Infrastructure; Institution; Intellectual Property; Investigation; Legal; Link; Malignant Neoplasms; Medicine; Modeling; Molecular; Monitor; Nature; Neoadjuvant Therapy; Newsletter; Patients; Performance; Physicians; Pilot Projects; Process; Radiation; Radiation Oncology; Radiation therapy; Radiobiology; Radiometry; Rectal Cancer; Reporting; Research; Research Project Grants; Resource Sharing; Rest; Robin bird; Role; Running; Scientist; Secure; Self Assessment; Site; Specific qualifier value; Specimen; Tissues; Training; Training Activity; Tumor stage; candidate identification; community building; data sharing; design; experience; international center; meetings; member; microbiome; novel; organizational structure; programs; prospective; radiation effect; radiomics; recruit; success; tool; tumor

The ROBIN Administrative Core (AC) provides administrative and communication infrastructure to the ROBIN grant. Led by the three P.I.s, the AC is supported by an executive committee, composed by the leaders of the Cores, of the Molecular Characterization Trial (MCT) and of the scientific projects. The AC has a prestigious External Advisory Board (EAB), with members who represent all the disciplines and expertise relevant to this ROBIN. A team of experienced patients advocates, completes the organizational chart. An Executive Director will be recruited if the ROBIN is funded, in charge of maintaining communication and coordination of all ROBIN activities. To this scope the ROBIN Tracker will be introduced, adapted from an IT tool developed at Weill Cornell Medicine for electronic communication of activities and tasks of large grants (like SPORE or PPG). An important role of the AC is to develop a semestral evaluation plan and share it with the EAB, and if necessary, at ad hoc meetings when important decisions need to be made. Metrics of success will include the timely achievement of completion of MTAs and other legal steps to enable transfer between academic institutions of research specimens in the US, and of research data both in the US and Europe. Planned accruals to the MCT, generation of preliminary data from the scientific projects, and successful integration of trainees within the ROBIN programs are additional metrics of success. The iterative nature of ROBIN will also be assessed, as it is expected that the results of the first MCT and the associated scientific projects (converged with the feedback and results from the other centers in the ROBIN network) will inspire the design of one or more new MCT, around year 3. These new MCT will be implemented during the last two years of the award through the existing Immunology and Radiation Oncology Network (IRON) that will run the proposed first MCT. Another important role of the AC consists of assessing the Cross Training Core (CTC). While metrics of success of the CTC are defined in detail in its planned self-assessment, the AC will monitor the CTC to ensure a harmonious integration of the different disciplines and expertise that characterize ROBIN and are indispensable to a cross training in Radiation and Immunity, the overarching theme of this ROBIN proposal. A central duty of the AC is to identify potential collaborations within and beyond the ROBIN network and participate in the process of actualizing the restricted fund pilot projects program of the ROBIN network. The ROBIN newsletter proposed in the CTC, with distribution across the network will advertise the RFA. In addition, each of the ten academic institutions involved in this ROBIN will use their internal communication mechanisms to solicit applications. We expect the applications to be evaluated by a committee formed by representatives of each funded ROBIN. The AC will select representation from this ROBIN, based on the need of the committee, with consideration to ensure its diversity (gender balance, diversity of expertise and seniority, etc.). Finally, the AC leaders will participate in the executive activities of the ROBIN network and will be the link for bidirectional communication between this ROBIN and the rest of the network.

ROBIN管理核心（AC）为ROBIN提供管理和通信基础设施 格兰特. AC由三个PI领导，由执行委员会支持，执行委员会由以下领导人组成： 核心，分子表征试验（MCT）和科学项目。AC有一个著名的 外部咨询委员会（EAB），其成员代表与此相关的所有学科和专业知识 罗宾一个由经验丰富的病人倡导者组成的团队完成了组织结构图。执行董事 如果ROBIN得到资助，我将被招募，负责维护所有ROBIN的沟通和协调 活动为此，将引入ROBIN跟踪器，该跟踪器改编自Weill Cornell开发的IT工具 用于大型赠款（如SPORE或PPG）活动和任务的电子通信的医学。一个重要 咨询委员会的职责是制定半年度评估计划，并与行政咨询委员会共享，如有必要， 在需要做出重要决定的时候召开会议。成功的关键将包括及时实现 完成多边贸易协定和其他法律的步骤，以便在学术研究机构之间进行转让 在美国的标本，并在美国和欧洲的研究数据。MCT的计划应计费用，生成 科学项目的初步数据，以及ROBIN计划中学员的成功整合 是衡量成功的额外标准。还将评估ROBIN的迭代性质，因为预计 第一次中期试验的结果和相关的科学项目（与第二次中期试验的反馈和结果相结合） ROBIN网络中的其他中心）将在第3年左右激发一个或多个新MCT的设计。这些新 MCT将在该奖项的最后两年通过现有的免疫学和放射学实施 肿瘤学网络（IRON）将运行拟议的第一个MCT。顾问委员会的另一个重要角色包括 交叉训练核心（CTC）。虽然气候技术中心成功的衡量标准在其计划的 在自我评估过程中，咨询委员会将监督CTC，以确保不同学科的和谐融合， ROBIN特有的专业知识，是辐射和免疫交叉培训不可或缺的， 这是ROBIN提案的主题。AC的核心职责是确定内部的潜在合作 以及ROBIN网络之外的其他网络，并参与限制性基金试点项目的实施过程 ROBIN网络。在反恐委员会提议的ROBIN通讯，在整个网络分发 将为RFA做广告。此外，参与此次ROBIN的十个学术机构将各自使用其 内部沟通机制，以征求申请。我们希望申请书由一个 委员会由每个资助ROBIN的代表组成。AC将从这个ROBIN中选择代表， 根据委员会的需要，并考虑到确保其多样性（性别平衡、 专业知识和资历等）。最后，AC领导人将参加ROBIN的执行活动 网络，并将成为该ROBIN与网络其余部分之间双向通信的链路。