Administrative Core

行政核心

• 批准号: 10517805
• 负责人: Silvia C. Formenti
• 金额: $ 14.05万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517805
• 关键词: Achievement; Adverse event; Advocate; Age; Award; Charge; Clinical Trials; Collaborations; Colorectal; Communication; Data; Data Analyses; Data Element; Data Scientist; Descriptor; Discipline; Electronic Mail; Ensure; Equilibrium; Ethics; Europe; Evaluation; Feedback; Funding; Future; Gender; Generations; Grant; Image; Immune; Immune response; Immune system; Immunity; Immunology; Immunooncology; Infrastructure; Institution; Intellectual Property; Investigation; Legal; Link; Malignant Neoplasms; Medicine; Modeling; Molecular; Monitor; Nature; Neoadjuvant Therapy; Newsletter; Patients; Performance; Physicians; Pilot Projects; Process; Radiation; Radiation Oncology; Radiation therapy; Radiobiology; Radiometry; Rectal Cancer; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Rest; Role; Running; Scientist; Secure; Self Assessment; Site; Specific qualifier value; Specimen; Time; Tissue imaging; Tissues; Training; Training Activity; Tumor stage; base; community building; data sharing; design; experience; international center; meetings; member; microbiome; novel; organizational structure; programs; prospective; radiation effect; radiomics; recruit; success; tool; tumor

The ROBIN Administrative Core (AC) provides administrative and communication infrastructure to the ROBIN grant. Led by the three P.I.s, the AC is supported by an executive committee, composed by the leaders of the Cores, of the Molecular Characterization Trial (MCT) and of the scientific projects. The AC has a prestigious External Advisory Board (EAB), with members who represent all the disciplines and expertise relevant to this ROBIN. A team of experienced patients advocates, completes the organizational chart. An Executive Director will be recruited if the ROBIN is funded, in charge of maintaining communication and coordination of all ROBIN activities. To this scope the ROBIN Tracker will be introduced, adapted from an IT tool developed at Weill Cornell Medicine for electronic communication of activities and tasks of large grants (like SPORE or PPG). An important role of the AC is to develop a semestral evaluation plan and share it with the EAB, and if necessary, at ad hoc meetings when important decisions need to be made. Metrics of success will include the timely achievement of completion of MTAs and other legal steps to enable transfer between academic institutions of research specimens in the US, and of research data both in the US and Europe. Planned accruals to the MCT, generation of preliminary data from the scientific projects, and successful integration of trainees within the ROBIN programs are additional metrics of success. The iterative nature of ROBIN will also be assessed, as it is expected that the results of the first MCT and the associated scientific projects (converged with the feedback and results from the other centers in the ROBIN network) will inspire the design of one or more new MCT, around year 3. These new MCT will be implemented during the last two years of the award through the existing Immunology and Radiation Oncology Network (IRON) that will run the proposed first MCT. Another important role of the AC consists of assessing the Cross Training Core (CTC). While metrics of success of the CTC are defined in detail in its planned self-assessment, the AC will monitor the CTC to ensure a harmonious integration of the different disciplines and expertise that characterize ROBIN and are indispensable to a cross training in Radiation and Immunity, the overarching theme of this ROBIN proposal. A central duty of the AC is to identify potential collaborations within and beyond the ROBIN network and participate in the process of actualizing the restricted fund pilot projects program of the ROBIN network. The ROBIN newsletter proposed in the CTC, with distribution across the network will advertise the RFA. In addition, each of the ten academic institutions involved in this ROBIN will use their internal communication mechanisms to solicit applications. We expect the applications to be evaluated by a committee formed by representatives of each funded ROBIN. The AC will select representation from this ROBIN, based on the need of the committee, with consideration to ensure its diversity (gender balance, diversity of expertise and seniority, etc.). Finally, the AC leaders will participate in the executive activities of the ROBIN network and will be the link for bidirectional communication between this ROBIN and the rest of the network.

ROBIN 管理核心 (AC) 为 ROBIN 提供管理和通信基础设施 授予。审计委员会由三位 P.I. 领导，并得到一个执行委员会的支持，该执行委员会由各委员会的领导人组成 分子表征试验 (MCT) 和科学项目的核心。 AC 拥有享有盛誉的 外部顾问委员会 (EAB)，其成员代表与此相关的所有学科和专业知识 罗宾。由经验丰富的患者组成的团队倡导，完成组织结构图。执行董事 如果ROBIN获得资助，将被招募，负责维护所有ROBIN的沟通和协调 活动。为此，将引入 ROBIN 跟踪器，该跟踪器改编自威尔康奈尔大学开发的 IT 工具 用于大笔赠款活动和任务的电子通信的医学（如 SPORE 或 PPG）。一个重要的 AC 的作用是制定学期评估计划并与 EAB 共享，如有必要，可临时共享 需要做出重要决定时召开的会议。成功的衡量标准将包括及时实现 完成 MTA 和其他法律步骤，以实现学术研究机构之间的转移 美国的标本以及美国和欧洲的研究数据。 MCT 的计划应计费用，发电 科学项目的初步数据以及受训者成功融入 ROBIN 计划 是衡量成功的附加指标。 ROBIN 的迭代性质也将被评估，因为预计 第一次 MCT 和相关科学项目的结果（与来自 ROBIN 网络中的其他中心）将在第 3 年左右激发一个或多个新 MCT 的设计。这些新的 MCT 将在获奖后的最后两年通过现有的免疫学和放射学实施 肿瘤学网络 (IRON) 将运行拟议的第一个 MCT。审计委员会的另一个重要作用包括 评估交叉训练核心（CTC）。虽然 CTC 的成功指标在其计划中详细定义 自我评估后，审计委员会将监督 CTC，以确保不同学科和领域的和谐整合。 ROBIN 的专业知识对于辐射和免疫领域的交叉培训是不可或缺的， ROBIN 提案的总体主题。审计委员会的核心职责是确定内部潜在的合作 并超越ROBIN网络，参与限制性基金试点项目的实施过程 ROBIN 网络的程序。 CTC 提议的 ROBIN 时事通讯，并通过网络分发 将为 RFA 做广告。此外，参与本次 ROBIN 的十个学术机构中的每一个都将使用他们的 征求申请的内部沟通机制。我们希望这些应用程序能够由 由每个资助的 ROBIN 的代表组成的委员会。 AC 将从该 ROBIN 中选择代表， 根据委员会的需要，并考虑确保其多样性（性别平衡、成员多样性） 专业知识和资历等）。最后，AC领导将参与ROBIN的执行活动 网络，并将成为该 ROBIN 与网络其余部分之间双向通信的链接。