The Interplay between Glucose Metabolism and Heat in Kidney Disease using a Metabolomics Approach
使用代谢组学方法研究肾脏疾病中葡萄糖代谢与热量之间的相互作用
基本信息
- 批准号:10708153
- 负责人:
- 金额:$ 14.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-21 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AcclimatizationAcute Renal Failure with Renal Papillary NecrosisAgeAgricultureAldosteroneAreaAutomobile DrivingAwarenessBig Data MethodsBioinformaticsBiological MarkersBiological MonitoringBloodBlood GlucoseBody TemperatureBody mass indexCaliforniaCessation of lifeChronicChronic Kidney FailureClinicalCommunitiesCommunity HealthComplexCreatinineDataDedicationsDehydrationDevelopmentDiabetes MellitusDisease ProgressionDoctor of PhilosophyEarly InterventionEnvironmentFastingFloridaFundingFutureGenerationsGlucoseGlycosylated HemoglobinGlycosylated hemoglobin AGoalsGuatemalaHarvestHealthHeart RateHeat Stress DisordersHeat-Shock Proteins 90HispanicHispanic PopulationsIL8 geneImmigrantImpairmentIndustryInflammationInflammatoryInterleukin-1 betaInterleukin-10Interleukin-6Intervention TrialInvestigationKidneyKidney DiseasesLatinaLinkLongitudinal StudiesMentored Patient-Oriented Research Career Development AwardMentorshipMetabolicMetabolic PathwayNephrologyNon-Insulin-Dependent Diabetes MellitusNot Hispanic or LatinoNursesOccupationalPathway AnalysisPathway interactionsPhenotypePhysiologicalPlasmaPlayPopulationPrediabetes syndromePrevalenceProteinuriaProtocols documentationRenal functionResearchResolutionRiskRisk FactorsRoleSamplingScienceScientistSeasonsSerumSignal TransductionSubgroupSymptomsTNF geneTemperatureTimeTrainingUnited States National Institutes of HealthUric AcidVulnerable PopulationsWeatherWorkbilingualismclinical phenotypecohortdesigndisorder riskearly detection biomarkersfarm workerglucose metabolismhealth care availabilityhealth disparityhealth equityhot climatekidney dysfunctionmetabolic profilemetabolomemetabolomicsmortalitynephrogenesisnovelpopulation healthprogramsrecruitrenal damageresponsesexsuccess
项目摘要
PROJECT SUMMARY
Roxana Chicas, PhD, RN is a 1st generation bilingual Latina and her goal is to become an independent NIH-
funded nurse scientist developing a sustainable research program in the area of
glucose metabolism and
kidney disease. Support from the K23 award will provide the dedicated research time that will enable
fundamental training and mentorship to further her understanding of: 1) the relationship of
glucose metabolic
pathways and heat exposure and the development of
kidney disease in farmworkers using a metabolomics
approach; and 2) the design and management of community-engaged intervention trials to decrease the risk of
heat stress, renal dysfunction, and glucose dysregulation in vulnerable populations. Heat is the leading cause
of weather-related deaths in the US, and farmworkers comprise an occupational sector particularly vulnerable
to heat-related illness (HRI). Between 2-3 million workers in the US agricultural industry are at risk of heat
related mortality at a rate that is 35 times greater than that of the general workforce population. In the last
decade a number of investigations have shown a link between heat exposure and the risk of acute kidney
injury (AKI). The chronic effects of the insidious and unexplained uptick of AKI among farmworkers, and the
disproportionate burden of HRI and repetitive heat stress-induced dehydration are not well understood. The
role that predisposing health conditions such as prediabetes may play in the risk of AKI has not been
examined. While studies have documented heat-related risk factors and the body’s physiologic response to
heat, few investigations have considered whether glucose metabolism and high environmental heat conditions
are a risk factor for acute kidney injury, and less is known about the metabolic pathways underlying the body’s
response to heat stress. The goal of this project is to characterize the physiologic phenotypes of farmworkers
across seasons and exposures (indoors v. outdoors), using non-targeted, high-resolution metabolomics (HRM)
to compare metabolomic profiles, and examine the associations between HRI clinical profiles (including core
body temperature, heart rate, dehydration, HRI symptoms); inflammation biomarkers (IL-10, IL-6, IL-8, IL-1β,
TNF-α, HSP72, HSP90); renal biomarkers (serum creatinine, BUN, eGFR, proteinuria, uric acid; aldosterone,
and copeptin); and glucose clinical profiles (HbA1c, AM fasting blood glucose, and PM blood glucose levels).
This proposed study will explore interplay of glucose metabolism and HRI and advance our understanding of
the physiologic underpinnings of AKI and renal function. The incorporation of metabolomic profiles will add to
the state of the science by indicating the underlying metabolic mechanisms and consequences of the
physiologic response to heat stress.
项目摘要
Roxana Chicas博士,RN是第一代双语拉丁裔,她的目标是成为一个独立的NIH-
资助护士科学家在该领域制定可持续的研究计划,
葡萄糖代谢和
肾病K23奖的支持将提供专门的研究时间,
基本的培训和指导,以进一步她的理解:1)关系
糖代谢
途径和热暴露以及
利用代谢组学研究农民肾脏疾病
方法;和2)社区参与干预试验的设计和管理,以降低
弱势群体的热应激、肾功能障碍和血糖失调。热是主要原因
在美国,与天气有关的死亡人数占总死亡人数的70%,而农业工人是一个特别脆弱的职业部门。
热相关疾病(HRI)。美国农业部门有200 - 300万工人面临高温风险
与此相关的死亡率是一般劳动力人口的35倍。在过去
近十年来,许多研究表明,热暴露与急性肾脏病风险之间存在联系。
损伤(阿基)。农业工人中阿基的阴险和无法解释的上升的慢性影响,以及
不成比例的HRI负担和反复热应激诱导的脱水还没有很好的理解。的
易感性健康状况(如前驱糖尿病)在阿基风险中可能发挥的作用尚未得到证实。
考察虽然研究已经记录了与热有关的风险因素和身体对热的生理反应,
热,很少有研究考虑到葡萄糖代谢和高环境热条件
是急性肾损伤的一个危险因素,但对人体代谢途径的了解较少。
热应激反应。这个项目的目标是描述农场工人的生理表型
跨季节和暴露(室内与室外),使用非靶向,高分辨率代谢组学(HRM)
比较代谢组学特征,并检查HRI临床特征(包括核心
体温、心率、脱水、HRI症状);炎症生物标志物(IL-10,IL-6,IL-8,IL-1β,
TNF-α、HSP 72、HSP 90);肾生物标志物(血清肌酐、BUN、eGFR、蛋白尿、尿酸;醛固酮,
和肽素);和葡萄糖临床特征(HbA 1c、AM空腹血糖和PM血糖水平)。
这项研究将探讨糖代谢和HRI的相互作用,并促进我们对HRI的理解。
阿基和肾功能的生理基础。代谢组学特征的结合将增加
通过指出潜在的代谢机制和结果的科学状态
热应激的生理反应
项目成果
期刊论文数量(0)
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Roxana Cristina Chicas其他文献
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{{ truncateString('Roxana Cristina Chicas', 18)}}的其他基金
The Interplay between Glucose Metabolism and Heat in Kidney Disease using a Metabolomics Approach
使用代谢组学方法研究肾脏疾病中葡萄糖代谢与热量之间的相互作用
- 批准号:
10429561 - 财政年份:2022
- 资助金额:
$ 14.83万 - 项目类别: