Research Training Program in Cardiovascular Surgery

心血管外科研究培训计划

• 批准号: 10707775
• 负责人: Todd K Rosengart
• 金额: $ 34.85万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707775
• 关键词: Cardiovascular Surgical Procedures; Research Training; Training Programs

This is a first competitive renewal application for a thriving T32 Research Training Program in Cardiovascular Surgery. Cardiovascular diseases and their complications are leading causes of death and disability in the United States. The health implications of surgical cardiovascular disease create a strong need to ensure sustained research by training future investigators in the field. Unfortunately, graduates of cardiac and vascular surgery training programs face steep challenges to establishing research careers. Taking advantage of our position in the Texas Medical Center, the largest medical complex in the world, our postdoctoral training program in cardi- ovascular surgical research is designed to: (1) increase the pool of MDs and PhDs who enter cardiovascular surgical research careers, and (2) provide our trainees with the skills necessary to be successful and productive in cardiovascular research. We accept two trainees per year (MD surgery residents, other clinicians, or PhDs) into three training tracks, each two years in duration: bioengineering and biodesign, basic and translational re- search, and data science and health services research. Trainees can pursue diverse research career training opportunities, yet in all cases the focus is on addressing a clinical problem relevant to cardiovascular surgeons. To provide a range of training opportunities and mentorship, we have recruited 22 mentors from Baylor College of Medicine (BCM), Rice University, and the University of Houston. Within the three training tracks, the 22 men- tors are grouped into specific themes, such as “aortic disease,” based on their expertise and existing collabora- tive relationships. Each track allows trainees the option of completing a degree, such as a Master’s Degree in Bioinformatics; [all tracks include a mandatory Grant Writing course.] Our Program Director is Todd Rosengart, MD, Chair of the Michael E. DeBakey Department of Surgery at BCM; Co-Directors are Scott LeMaire, MD, Vice Chair for Research, and Barbara Trautner, MD, PhD, Director of Clinical and Health Services Research. Our leadership is supported by an Executive Steering Committee, a diverse panel of 11 local experts in research education and mentoring. Program leadership is also guided by an External Advisory Committee composed of five scientists who have all directed and/or served as a mentor in T32 training programs. Over the past five application years, we received 91 inquiries about the program from across the United States, leading to 10 trainees entering the program, three of whom were from surgical residency programs outside Houston. Our outreach through national professional organizations that support groups underrepresented in the scientific work- force has been fruitful; [36% of our accepted applicants are from a group underrepresented in biomedical sci- ences. Our three PhD graduates all secured an academic research position; our three MD graduates returned to clinical training. Collectively our trainees have published 64 manuscripts with their mentors, and three trainees secured external funding.] We look forward to the opportunity for our program to continue to grow the pool of highly qualified MDs and PhDs contributing to the high-impact arena of research in cardiovascular surgery.

这是蓬勃发展的 T32 心血管研究培训计划的第一个竞争性更新申请 外科手术。心血管疾病及其并发症是美国死亡和残疾的主要原因 国家。外科心血管疾病对健康的影响强烈需要确保持续 通过培训该领域未来的研究人员来进行研究。不幸的是，心脏和血管外科的毕业生 培训项目在建立研究职业方面面临着严峻的挑战。利用我们的地位 德克萨斯医学中心，世界上最大的医疗中心，我们的心脏病博士后培训项目 血管外科研究的目的是：（1）增加进入心血管领域的医学博士和博士的数量 外科研究职业，(2) 为我们的学员提供成功和高效所需的技能 在心血管研究中。我们每年接受两名实习生（医学博士外科住院医生、其他临床医生或博士） 分为三个培训轨道，每两年持续时间：生物工程和生物设计、基础和转化再培训 搜索、数据科学和健康服务研究。学员可以接受多样化的研究职业培训 机会，但在所有情况下，重点都是解决与心血管外科医生相关的临床问题。 为了提供一系列的培训机会和指导，我们从贝勒学院招募了 22 名导师 医学博士（BCM）、莱斯大学和休斯顿大学。在三个训练轨道中，22名男子—— 根据他们的专业知识和现有的合作，他们被分为特定的主题，例如“主动脉疾病” 积极的关系。每个课程都允许学员选择完成学位，例如硕士学位 生物信息学； [所有课程都包括必修的资助写作课程。] 我们的项目总监是托德·罗森加特 (Todd Rosengart)， 医学博士、BCM Michael E. DeBakey 外科主任；联合董事是斯科特·勒梅尔 (Scott LeMaire)，医学博士、副主任 研究主席、医学博士、博士、临床和健康服务研究主任 Barbara Trautner。我们的 领导层得到执行指导委员会的支持，该委员会是一个由 11 名当地研究专家组成的多元化小组 教育和指导。项目领导还受到外部咨询委员会的指导，该委员会由以下人员组成： 五位科学家都曾指导和/或担任过 T32 培训项目的导师。过去五年 申请期间，我们收到了来自美国各地有关该计划的 91 份询问，其中 10 参加该项目的学员中，其中三人来自休斯顿以外的外科住院医师项目。我们的 通过支持科学工作中代表性不足的群体的国家专业组织进行外展活动 武力已卓有成效； [我们接受的申请者中有 36% 来自生物医学科学领域代表性不足的群体 恩斯。我们的三名博士毕业生均获得了学术研究职位；我们的三位医学博士毕业生归来 到临床培训。我们的学员与导师共同发表了 64 篇手稿，其中 3 名学员 获得外部资金。]我们期待着我们的计划有机会继续扩大人才库 高素质的医学博士和博士为心血管外科研究的高影响力领域做出了贡献。

项目成果

The detrimental association between fear of falling and motor performance in older cancer patients with chemotherapy-induced peripheral neuropathy.

• DOI: 10.1016/j.gaitpost.2021.05.022
• 发表时间: 2021-07
• 期刊: Gait & posture
• 影响因子: 2.4
• 作者: Kang GE;Murphy TK;Kunik ME;Badr HJ;Workeneh BT;Yellapragada SV;Sada YH;Najafi B
• 通讯作者: Najafi B

Current state of the art in hypoplastic left heart syndrome.

• DOI: 10.3389/fcvm.2022.878266
• 发表时间: 2022
• 期刊: Frontiers in cardiovascular medicine
• 影响因子: 3.6

The Cellular and Molecular Effects of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia.

• DOI: 10.3389/fped.2022.925106
• 发表时间: 2022
• 期刊: FRONTIERS IN PEDIATRICS
• 影响因子: 2.6
• 作者: Olutoye, Oluyinka O., II;Short, Walker D.;Gilley, Jamie;Hammond, J. D., II;Belfort, Michael A.;Lee, Timothy C.;King, Alice;Espinoza, Jimmy;Joyeux, Luc;Lingappan, Krithika;Gleghorn, Jason P.;Keswani, Sundeep G.
• 通讯作者: Keswani, Sundeep G.

Advancing pediatric medical device development via non-dilutive NIH SBIR/STTR grant funding.

• DOI: 10.1016/j.jpedsurg.2021.01.025
• 发表时间: 2021-11
• 期刊: Journal of pediatric surgery
• 影响因子: 2.4
• 作者: Sun RC;Kamat I;Byju AG;Wettergreen M;Heffernan MJ;Willson R;Haridas B;Koh CJ
• 通讯作者: Koh CJ

Machine learning for dynamic and early prediction of acute kidney injury after cardiac surgery.

机器学习用于心脏手术后急性肾损伤的动态和早期预测。

• DOI: 10.1016/j.jtcvs.2022.09.045
• 发表时间: 2023
• 期刊: The Journal of thoracic and cardiovascular surgery
• 作者: Ryan,ChristopherT;Zeng,Zijian;Chatterjee,Subhasis;Wall,MatthewJ;Moon,MarcR;Coselli,JosephS;Rosengart,ToddK;Li,Meng;Ghanta,RaviK
• 通讯作者: Ghanta,RaviK