Epigenetic regulation of social and behavioral plasticity in ants
蚂蚁社会和行为可塑性的表观遗传调控
基本信息
- 批准号:10707189
- 负责人:
- 金额:$ 40.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-22 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAggressive behaviorAntibodiesAntsBehaviorBehavior DisordersBehavioralBehavioral AssayBiochemicalBiological ModelsBrainCastesCellsChromatinChromatin StructureCuesDataDiscipline of NursingERG geneEpigenetic ProcessGene ExpressionGenesGenetic TranscriptionGenomeGenomic approachGoalsGonadotropin Hormone Releasing HormoneHomologous GeneHumanImmunofluorescence ImmunologicImpaired cognitionIn Situ HybridizationInsectaMammalsMental RetardationMental disordersMetabolismModelingMolecularNeurodevelopmental DisorderNeuronsNeuropeptidesPathway interactionsPhenotypePhysiologyProcessProteinsPublishingRegulationRepressionReproductionRoleSocial BehaviorSocial EnvironmentSpecific qualifier valueTestingVasopressin ReceptorVasopressinsWorkbehavioral genomicsbehavioral plasticityeggepigenetic regulationexperienceexperimental studyfunctional genomicsgenetic approachgenetic manipulationin vivoinsightpharmacologicpreventprogramsresponsesingle-cell RNA sequencingsocialtranscription factortranscriptome sequencing
项目摘要
ABSTRACT
The goal of this proposal is to determine how epigenetic pathways regulate plasticity in social behaviors
using the model ant Harpegnathos saltator. Specifically, we will test the hypothesis that external social cues
are conveyed to chromatin by neuropeptides that regulate downstream transcription factors and associated
epigenetic pathways to enable stable changes in social behavior.
Epigenetic pathways are often disrupted in neurodevelopmental and behavioral disorders. Harpegnathos
ants are an ideal model system to study brain epigenetics because workers and queens have the same genes
but display distinct social behaviors. Furthermore, adult Harpegnathos workers can become queens via a
remarkable phenotypic transition that involves plastic changes in reproduction, metabolism, and behavior.
We have discovered that the ant homolog of the human gonadotropin-releasing hormone, the neuropeptide
corazonin, is downregulated as Harpegnathos workers become queens and showed that it is necessary and
sufficient to stimulate hunting in workers. Our preliminary data show that vasopressin, a neuropeptide with
conserved social roles in mammals, is also preferentially expressed in worker brains, especially in those who
do not express high levels of corazonin. In Aim 1, we will determine whether these two neuropeptides act on
distinct or overlapping neuronal, molecular, and epigenetic pathways and whether they drive distinct social
behaviors.
Our previous work also revealed that Kr-h1, a transcription factor induced by corazonin, prevents unscheduled
activation of “socially inappropriate” genes in the brain, thereby maintaining proper social behavior in both
workers and gamergates. Preliminary studies identified another transcription factor, Fd3F, which is repressed
by corazonin and might promote social plasticity in opposition to Kr-h1. Fd3F shares homology with pioneer
transcription factors in other species, suggesting that an ability to reprogram chromatin states might underpin
its function in behavioral reprogramming. In Aim 2, we will identify the changes on transcription and chromatin
by which these transcription factors regulate brain and behavioral plasticity during adult caste transitions in
Harpegnathos.
The proposed experiments will leverage our previous experience with in vivo manipulation of gene expression
in ant brains followed by behavioral and functional genomics analyses. Given that the neuropeptides,
transcription factors, and epigenetic regulators investigated in this proposal are deeply conserved, our results
should have broad impact on our understanding of how these molecular processes regulate social behavior.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Roberto Bonasio其他文献
Roberto Bonasio的其他文献
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{{ truncateString('Roberto Bonasio', 18)}}的其他基金
Epigenetic regulation of social and behavioral plasticity in ants
蚂蚁社会和行为可塑性的表观遗传调控
- 批准号:
10567966 - 财政年份:2022
- 资助金额:
$ 40.63万 - 项目类别:
Social control of lifespan regulation via glial plasticity in ants
通过蚂蚁的神经胶质可塑性对寿命调节的社会控制
- 批准号:
10197364 - 财政年份:2021
- 资助金额:
$ 40.63万 - 项目类别:
Genetically engineered ants to label and study neurons involved in social behavior
基因工程蚂蚁可以标记和研究参与社会行为的神经元
- 批准号:
10218394 - 财政年份:2021
- 资助金额:
$ 40.63万 - 项目类别:
Social control of lifespan regulation via glial plasticity in ants
通过蚂蚁的神经胶质可塑性对寿命调节的社会控制
- 批准号:
10390333 - 财政年份:2021
- 资助金额:
$ 40.63万 - 项目类别:
Social control of lifespan regulation via glial plasticity in ants
通过蚂蚁的神经胶质可塑性对寿命调节的社会控制
- 批准号:
10583467 - 财政年份:2021
- 资助金额:
$ 40.63万 - 项目类别:
Genetically engineered ants to label and study neurons involved in social behavior
基因工程蚂蚁可以标记和研究参与社会行为的神经元
- 批准号:
10370381 - 财政年份:2021
- 资助金额:
$ 40.63万 - 项目类别:
Regulation of PRC2 by protein and RNA interactions during differentiation
分化过程中蛋白质和 RNA 相互作用对 PRC2 的调节
- 批准号:
10228033 - 财政年份:2020
- 资助金额:
$ 40.63万 - 项目类别:
Regulation of PRC2 by protein and RNA interactions during differentiation
分化过程中蛋白质和 RNA 相互作用对 PRC2 的调节
- 批准号:
10426204 - 财政年份:2020
- 资助金额:
$ 40.63万 - 项目类别:
Regulation of PRC2 by protein and RNA interactions during differentiation
分化过程中蛋白质和 RNA 相互作用对 PRC2 的调节
- 批准号:
10640190 - 财政年份:2020
- 资助金额:
$ 40.63万 - 项目类别:
Regulation of PRC2 by protein and RNA interactions during differentiation
分化过程中蛋白质和 RNA 相互作用对 PRC2 的调节
- 批准号:
10031001 - 财政年份:2020
- 资助金额:
$ 40.63万 - 项目类别:
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